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Chemical Diphosphonates

Name Diphosphonates
Equivalent Term Bisphosphonates
Definition Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Curator Note For additional curated data about phosphorus, please also see Phosphorus and its chemical descendants.
Top Interacting
Genes
MeSH® ID D004164
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Top ↑ Ancestors

ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Organophosphorus Compounds Has associated genes Has associated diseases Has associated exposure references Organophosphonates Has associated genes Has associated diseases Has associated exposure references Diphosphonates Has associated genes Has associated diseases

Top ↑ Descendants

Diphosphonates Has associated genes Has associated diseases
  1,1-hydroxyoctanodiphosphonate
  1,2-dipalmitoyloxypropyl-3-(2'-hydroxypropyl-3'-(1'',2''-dipalmitoylglycerol))biphosphonate
  153Sm-BPAMD
  1-aminoethylene diphosphonic acid
  1-fluoro-2-(3-pyridinyl)ethylidene-1,1-bisphosphonic acid
  1-fluorononylidene-1,1-bisphosphonic acid
  1-hydroxy-2-(3-indolyl)ethane-1,1-diphosphonic acid
  1-hydroxy-2-(4-aminophenyl)ethane-1,1-diphosphonic acid
  1-hydroxy-2-(4-methyl-1H-imidazol-1-yl)-ethylidene-1,1-bisphosphonic acid
  1-hydroxypentane-1,1-bisphosphonate
  1-((N-(2,3,4,5,6-pentafluorocinnamoyl)-O-(2,6-dichlorobenzyl))tyrosyl)-4-(bis(diethoxyphosphono))methylaminiopiperidine
  2-(1-imidazole)-1-hydroxy-1,1'-ethylidenediphosphonic acid
  2-(2-pyridyl)ethylidine-1,1-bisphosphonate
  2-(3'-dimethylaminopyrazinio)ethylidene-1,1-bisphosphonic acid betaine
  2-(3-picolyl)aminomethylene-1,1-bisphosphonic acid
  2-(3-pyridinyl)-1-hydroxyethylidene-1,1-phosphonocarboxylic acid Has associated genes
  (2-(6-aminopurine-9-yl)-1-hydroxy-phosphine acyl ethyl)phosphonic acid
  2-iminopyrrolidone-5,5-diphosphonic acid
  2-mercaptoethylidene-1,1-bisphosphonic acid
  2-sulfonato-1,1-ethylidene bisphosphonic acid
  3-astatobenzamido-N-3-hydroxypropylidene-3,3-bisphosphonate
  3-iodobenzamido-N-3-hydroxypropylidene-3,3-bisphosphonate
  4,4-bisphosphono-2-(polyhydroxyl-1,2-dihydro-1,2-methanofullerene(6)-61-carboxamido)butyric acid
  4,4'-(carbonylbis(imino-3,1-phenylenecarbonylimino-3,1-(4-methylphenylene)carbonylimino))bis(1,3-xylene-alpha,alpha'-diphosphonic acid) Has associated genes Has associated diseases
  4-amino-1-hydroxybutylidene-1,1-diphosphonate
  (4-(((bis(phosphonopropyl))carbamoyl)methyl)-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl)acetic acid
  (((((4-hydroxy-4,4-diphosphonobutyl)carbamoylmethyl)carbamoylmethyl)carbamoylmethyl)carbamoylmethanethiolate)oxorhenium(V)
  4-N,N-dimethylamino-1-hydroxybutylidene-1,1-diphosphonic acid
  4-phosphono-2-(phosphonomethyl)butanoate
  68Ga NOTA-bisphosphonate
  6-amino-1-hydroxyhexane-1,1-diphosphonate
  (90)Y-2,3-dicarboxypropane-1,1-diphosphonic acid
  99mTc-incadronate
  acetylamino propylidene diphosphonic acid
  acrylolpamidronate
  adipoylbisphosphonic acid
View node Alendronate Has associated genes Has associated diseases
  alpha-amino-(4-hydroxybenzylidene)diphosphonate
  aminobutane bisphosphonate
  aminomethane diphosphonate
  aminomethylene-bisphosphonic acid
  AP21946
  AP22188
  AP22408
  AP22409
  apomine Has associated genes Has associated diseases
  azacycloheptane-2,2-diphosphonate
  BBR 3053
  belfosdil
  benzene-1,4-bis(aminomethylidene(bisphosphonic)) acid
  benzylmethylenediphosphonic acid
  bis(ethylenediamine)(1-hydroxy-1-(pyridinium-4-yl)methane-1,1-bisphosphonate)diplatinum(II)
  bis(isopropyl methyl)phosphonate Has associated genes Has associated diseases
  BP 7033
  BPAMD ligand
  bromomethylenebis(phosphonic acid)
  carbonyldiphosphonate
  CGP 47072
  CGP 58318
  cimadronate Has associated diseases
View node Clodronic Acid Has associated genes Has associated diseases
  difluoromethylidene bisphosphonate
  digeranyl bisphosphonate Has associated genes
  diisopropyl methylenediphosphonate
  dimethylammonium hydrogen diphenyldiphosphonate
  dithioimidodiphosphinate
  DP-R206
  DTPA-1-hydroxy-3-aminopropane-1,1-diphosphonate
  DTPA-4-aminobutane-1,1-diphosphonate
  EB 1053 Has associated diseases
  ER 27856
  ER 28448
  ethane-1-hydroxy-1,1-bisphosphonate
  ethylidenediphosphonic acid
View node Etidronic Acid Has associated genes Has associated diseases
  (fluorescein-6-carbonyloxy)acetoaminomethylene bisphosphonic acid
  (fluoro(hydroxyphenylphosphinyl)methyl)phosphonic acid
  FR 78844
  hydroxymethanediphosphonic acid
  ibandronic acid Has associated genes Has associated diseases
  imidodiphosphonic acid
  ISA 13-1
  isopentenyl methylenediphosphonate
  isopropylidenediphosphonic acid
  L 690330
  L 690488
  LE-Cl2MDP Has associated genes Has associated diseases
  Me-BP7033
  methotrexate bisphosphonate
  methylene diphosphonate
  (N-(2-((3-(3,3-diphosphonopropylcarbamoyl)propyl)-2-thioethylamino)acetyl)-2-aminoethanethiolate)oxorhenium(V)
  (N-(2-((4-((4-hydroxy-4,4-diphosphonobutyl)amino)-4-oxobutyl)-2-thioethylamino)acetyl)-2-aminoethanethiolate)oxorhenium(V)
  naphthalene-1,5-bis(aminomethylidene(bisphosphonic)) acid
  NE 10244
  NE 21650
  NE 58051
  N-iso-butoxycarbonylpamidronate tetramethyl ester
  N-(methyl(4-phenylbutyl))-3-aminopropyl-1-hydroxy-1,1-bisphosphonate
  N,N-dimethylaminomethane diphosphonic acid
  N,N-dimethylenephosphonate-1-hydroxy-3-aminopropylidenediphosphonate
  N,N-dimethylenephosphonate-1-hydroxy-4-aminopropilydenediphosphonate
  olpadronic acid
  Oxonia Active
  P(1)-(7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthalan-1-one-2-yl)-P(2)-(2-ethyladenosin-5'-yl)methylenebis(phosphonate)
  pamidronate Has associated genes Has associated diseases
  pentane diphosphonate
  phenylacetate-bisphosphonate
  PNU 91638
  poly((acetone)tetraaqua(mu(6)-ethyl (dichloromethylene)diphosphonato)(mu(5)-ethyl (dichloromethylene)diphosphonato)tribarium(II))
  prolyl-phenylalanyl-pamidronate
  propane-2,2-diphosphonic acid
  propylenediaminetetramethylene phosphonate
  SK&F 99085
  SM 16896
  SR 12813 Has associated genes Has associated diseases
  SR 41319
  stannous methylene diphosphonate
  suberoylbisphosphonic acid
  sulfonyldiphenyl-4,4'-bis(aminomethylidene(bisphosphonic)) acid
View node Technetium Tc 99m Medronate
  technetium 99m 1-hydroxy-2-(2-isopropyl-1H-imidazole-1-yl)ethylidene-1,1-bisphosphonic acid
  technetium 99m 1-hydroxy-3-(1H-imidazol-1-yl)propane-1,1-diyldiphosphonic acid
  technetium 99m 1-hydroxy-4-(2-butyl-1H-imidazol-1-yl)butane-1,1-diyldiphosphonic acid
  technetium 99m 1-hydroxy-5-(2-butyl-1H-imidazol-1-yl)pentane-1,1-diyldiphosphonic acid
  technetium 99m 6-hydrazinopyridine-3-carboxylic acid-hydroxybisphosphonate
  technetium 99m hydroxyethylene-diphosphonate
  technetium 99m mercaptoacetylglycylglycylglycine-hydroxybisphosphonate
  technetium 99m methylene bisphosphonate
  technetium-99m-olpadronate
  technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid
  technetium Tc 99m 1,2-diphosphonoethylene glycol
  technetium Tc 99m 1-hydroxy-3-methylphosphinic-1,1-propanediphosphonic acid
  technetium Tc 99m 3-amino-1-hydroxypropane-1,1-diphosphonate
  technetium Tc 99m-aminodimethyldiphosphonic acid
  technetium Tc 99m aminohexylidendiphosphonate
  technetium Tc 99m carbonyl diphosphonic acid
  technetium Tc 99m dihydroxymethylene diphosphonic acid
  technetium Tc 99m dimethylaminodiphosphonate
  technetium Tc 99m dimethylaminomethylene diphosphonate
  technetium Tc 99m diphosphonate
  technetium Tc 99m hexylidenaminodiphosphonate
  technetium Tc 99m hydroxydiphosphonate
  technetium Tc 99m-N-carboxyethylaminodimethyldiphosphonic acid
  technetium Tc 99m (Sn)-imidodiphosphonic acid
  technetium Tc 99m (sodium borohydride)-dimethylaminomethylene diphosphonate
  tetraethyl anthracene-9,10-diyl-9,10-bis(phosphonate)
  tetrakispivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1-bisphosphonate
  tetra(pivaloyloxymethyl) (dichloromethylene)bisphosphonate
  tiludronic acid
  TRK 530
  YM 529 Has associated genes Has associated diseases
  ZK 90695
  zoledronic acid Has associated genes Has associated diseases