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Chemical Diphtheria Toxin

Name Diphtheria Toxin
Equivalent Terms Corynebacterium Diphtheriae Toxin | Toxin, Corynebacterium Diphtheriae
Definition An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Curation Status No gene interactions have been curated for this chemical yet.
MeSH® ID D004167
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Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Bacterial Toxins Has associated genes Has associated diseases Has associated exposure references Diphtheria Toxin Has associated diseases

Top ↑ Descendants

Diphtheria Toxin Has associated diseases
  CRM 107
  CRM 288
  DAB(389)-(Gly(4)-Ser)2-interleukin 3
  DAB(389)-GRP fusion protein, recombinant
  DAB(389)-interleukin 4
  DAB(389)-interleukin 6
  DAB(389) interleukin-7
  DAB(486)-interleukin 2
  denileukin diftitox Has associated diseases
  diphtheria toxin fragment A Has associated diseases
  diphtheria toxin fragment B
  diphtheria toxin-interleukin-3 fusion protein, recombinant
  diphtheria toxin-related-alpha-melanocyte-stimulating hormone fusion toxin
  diphtheria toxin-related-murine interleukin-4-fusion toxin
  DT 2219 immunotoxin
  dt(388) granulocyte-macrophage colony-stimulating factor
  DT390-anti-CD3sFv
  DTctGMCSF protein, recombinant
  FN18-CRM9
  GD5 protein, recombinant
  human chorionic gonadotropin-diphtheria toxin fragment A
  hybrid toxin, diphtheria-cholera
  insulin crosslinked to the catalytic fragment A of diphtheria toxin
  interleukin 2-diphtheria toxin
  IT-87 immunotoxin
  transferrin-diphtheria toxin conjugate
  VEGF121-diphtheria toxin conjugate