1. |
6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose
|
cell migration
|
|
6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose analog results in decreased cell migration |
1: Mus musculus |
Skin | Cell Line, Tumor |
2 genes: GSK3B | VEGFA
|
1 |
2. |
baicalein-7-O-diglucoside
|
response to endoplasmic reticulum stress
|
|
baicalein-7-O-diglucoside results in increased response to endoplasmic reticulum stress |
1: Homo sapiens |
B-Lymphocytes | Cell Line, Tumor |
2 genes: DDIT3 | HSPA5
|
1 |
3. |
baicalein-7-O-diglucoside
|
positive regulation of p38MAPK cascade
|
|
baicalein-7-O-diglucoside results in increased positive regulation of p38MAPK cascade |
1: Homo sapiens |
B-Lymphocytes | Cell Line, Tumor |
|
1 |
4. |
baicalein-7-O-diglucoside
|
positive regulation of apoptotic process
|
|
baicalein-7-O-diglucoside results in increased positive regulation of apoptotic process |
1: Homo sapiens |
B-Lymphocytes | Cell Line, Tumor |
2 genes: ATF6 | DDIT3
|
1 |
5. |
baicalein-7-O-diglucoside
|
positive regulation of cell proliferation
|
|
baicalein-7-O-diglucoside results in decreased positive regulation of cell proliferation |
1: Homo sapiens |
Cell Line, Tumor |
|
1 |
6. |
baicalein-7-O-diglucoside
|
positive regulation of p38MAPK cascade
|
SB 203580
|
SB 203580 inhibits the reaction [baicalein-7-O-diglucoside results in increased positive regulation of p38MAPK cascade] |
1: Homo sapiens |
B-Lymphocytes | Cell Line, Tumor |
|
1 |
7. |
baicalein-7-O-diglucoside
|
positive regulation of apoptotic process
|
SB 203580
|
SB 203580 inhibits the reaction [baicalein-7-O-diglucoside results in increased positive regulation of apoptotic process] |
1: Homo sapiens |
B-Lymphocytes | Cell Line, Tumor |
2 genes: ATF6 | DDIT3
|
1 |
8. |
Dietary Sucrose
|
regulation of blood pressure
|
Acarbose
| Sodium Chloride, Dietary
|
Acarbose inhibits the reaction [[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in increased regulation of blood pressure] |
1: Rattus norvegicus |
Cardiovascular System |
13 genes: ACSM3 | CYP4F18 | EPHX2 | HMOX1 | LEP | NOS2 | NOS3 | NPPA | NPPB | NPY | PPARG | SOD1 | SOD2
|
1 |
9. |
Dietary Sucrose
|
regulation of blood pressure
|
Sodium Chloride, Dietary
|
[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in increased regulation of blood pressure |
1: Rattus norvegicus |
Cardiovascular System |
13 genes: ACSM3 | CYP4F18 | EPHX2 | HMOX1 | LEP | NOS2 | NOS3 | NPPA | NPPB | NPY | PPARG | SOD1 | SOD2
|
1 |
10. |
Dietary Sucrose
|
positive regulation of urine volume
|
Sodium Chloride, Dietary
|
[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in decreased positive regulation of urine volume |
1: Rattus norvegicus |
Cardiovascular System |
2 genes: HAS2 | NPPB
|
1 |
11. |
Dietary Sucrose
|
positive regulation of urine volume
|
Acarbose
| Sodium Chloride, Dietary
|
Acarbose inhibits the reaction [[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in decreased positive regulation of urine volume] |
1: Rattus norvegicus |
Cardiovascular System |
2 genes: HAS2 | NPPB
|
1 |
12. |
Dietary Sucrose
|
renal sodium excretion
|
Sodium Chloride, Dietary
|
[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in decreased renal sodium excretion |
1: Rattus norvegicus |
Cardiovascular System |
|
1 |
13. |
Dietary Sucrose
|
renal sodium excretion
|
Acarbose
| Sodium Chloride, Dietary
|
Acarbose inhibits the reaction [[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in decreased renal sodium excretion] |
1: Rattus norvegicus |
Cardiovascular System |
|
1 |
14. |
Dietary Sucrose
|
response to oxidative stress
|
|
Dietary Sucrose results in increased response to oxidative stress |
1: Rattus norvegicus |
|
22 genes: ALDH1A1 | CAR3 | CAT | CST3 | DGKK | DUOX2 | GPX1 | GPX4 | GSR | HMOX1 | LCN2 | MT3 | NQO1 | PRDX6 | SCARA3 | SIRT1 | SLC7A11 | SOD1 | SOD2 | TPO | TRP53 | VNN1
|
1 |
15. |
Dietary Sucrose
|
lipid catabolic process
|
|
Dietary Sucrose results in decreased lipid catabolic process |
1: Rattus norvegicus |
|
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
16. |
Dietary Sucrose
|
response to oxidative stress
|
Acetylcysteine
|
Acetylcysteine inhibits the reaction [Dietary Sucrose results in increased response to oxidative stress] |
1: Rattus norvegicus |
|
22 genes: ALDH1A1 | CAR3 | CAT | CST3 | DGKK | DUOX2 | GPX1 | GPX4 | GSR | HMOX1 | LCN2 | MT3 | NQO1 | PRDX6 | SCARA3 | SIRT1 | SLC7A11 | SOD1 | SOD2 | TPO | TRP53 | VNN1
|
1 |
17. |
Dietary Sucrose
|
lipid catabolic process
|
Acetylcysteine
|
Acetylcysteine inhibits the reaction [Dietary Sucrose results in decreased lipid catabolic process] |
1: Rattus norvegicus |
|
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
18. |
Dietary Sucrose
|
response to oxidative stress
|
|
Dietary Sucrose results in increased response to oxidative stress |
1: Rattus norvegicus |
Heart |
22 genes: ALDH1A1 | CAR3 | CAT | CST3 | DGKK | DUOX2 | GPX1 | GPX4 | GSR | HMOX1 | LCN2 | MT3 | NQO1 | PRDX6 | SCARA3 | SIRT1 | SLC7A11 | SOD1 | SOD2 | TPO | TRP53 | VNN1
|
1 |
19. |
Dietary Sucrose
|
response to oxidative stress
|
Acetylcysteine
|
Acetylcysteine inhibits the reaction [Dietary Sucrose results in increased response to oxidative stress] |
1: Rattus norvegicus |
Heart |
22 genes: ALDH1A1 | CAR3 | CAT | CST3 | DGKK | DUOX2 | GPX1 | GPX4 | GSR | HMOX1 | LCN2 | MT3 | NQO1 | PRDX6 | SCARA3 | SIRT1 | SLC7A11 | SOD1 | SOD2 | TPO | TRP53 | VNN1
|
1 |
20. |
Dietary Sucrose
|
lipid catabolic process
|
|
Dietary Sucrose results in decreased lipid catabolic process |
1: Rattus norvegicus |
Heart |
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
21. |
Dietary Sucrose
|
lipid catabolic process
|
Acetylcysteine
|
Acetylcysteine inhibits the reaction [Dietary Sucrose results in decreased lipid catabolic process] |
1: Rattus norvegicus |
Heart |
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
22. |
Dietary Sucrose
|
triglyceride biosynthetic process
|
Dietary Fats
|
[Dietary Fats co-treated with Dietary Sucrose] results in increased triglyceride biosynthetic process |
2: Mus musculus | Rattus norvegicus |
Liver |
4 genes: ACSL4 | DGAT2 | LPIN1 | MOGAT1
|
2 |
23. |
Dietary Sucrose
|
triglyceride biosynthetic process
|
Betaine
| Choline
| Dietary Fats
| Folic Acid
| Vitamin B 12
|
[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased triglyceride biosynthetic process] |
1: Rattus norvegicus |
Liver |
4 genes: ACSL4 | DGAT2 | LPIN1 | MOGAT1
|
1 |
24. |
Dietary Sucrose
|
detection of glucose
|
Dietary Fats
|
[Dietary Fats co-treated with Dietary Sucrose] results in increased detection of glucose |
1: Rattus norvegicus |
Plasma |
2 genes: GCK | NKX6-1
|
1 |
25. |
Dietary Sucrose
|
DNA damage response, detection of DNA damage
|
|
Dietary Sucrose results in increased DNA damage response, detection of DNA damage |
1: Rattus norvegicus |
Colon |
|
1 |
26. |
Dietary Sucrose
|
cellular senescence
|
Dietary Fats
|
[Dietary Fats co-treated with Dietary Sucrose] results in increased cellular senescence |
1: Rattus norvegicus |
Aorta |
4 genes: CAV1 | CDKN1A | ID2 | PML
|
1 |
27. |
Dietary Sucrose
|
cellular senescence
|
Dietary Fats
| Resveratrol
|
Resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased cellular senescence] |
1: Rattus norvegicus |
Aorta |
4 genes: CAV1 | CDKN1A | ID2 | PML
|
1 |
28. |
Dietary Sucrose
|
mitochondrial electron transport, cytochrome c to oxygen
|
Copper
|
[Dietary Sucrose co-treated with Copper deficiency] results in decreased mitochondrial electron transport, cytochrome c to oxygen |
1: Rattus norvegicus |
Islets of Langerhans | Cells, Cultured |
|
1 |
29. |
Dietary Sucrose
|
positive regulation of insulin secretion involved in cellular response to glucose stimulus
|
Copper
|
[Dietary Sucrose co-treated with Copper deficiency] results in decreased positive regulation of insulin secretion involved in cellular response to glucose stimulus |
1: Rattus norvegicus |
Islets of Langerhans | Cells, Cultured |
6 genes: ATG7 | GHRL | GPR27 | HIF1A | NR1H4 | SIRT1
|
1 |
30. |
Dietary Sucrose
|
mitochondrial electron transport, cytochrome c to oxygen
|
Copper
|
Copper inhibits the reaction [[Dietary Sucrose co-treated with Copper deficiency] results in decreased mitochondrial electron transport, cytochrome c to oxygen] |
1: Rattus norvegicus |
Islets of Langerhans | Cells, Cultured |
|
1 |
31. |
Dietary Sucrose
|
positive regulation of insulin secretion involved in cellular response to glucose stimulus
|
Copper
|
Copper inhibits the reaction [[Dietary Sucrose co-treated with Copper deficiency] results in decreased positive regulation of insulin secretion involved in cellular response to glucose stimulus] |
1: Rattus norvegicus |
Islets of Langerhans | Cells, Cultured |
6 genes: ATG7 | GHRL | GPR27 | HIF1A | NR1H4 | SIRT1
|
1 |
32. |
Dietary Sucrose
|
positive regulation of insulin secretion involved in cellular response to glucose stimulus
|
Copper
|
[Dietary Sucrose co-treated with Copper deficiency] results in decreased positive regulation of insulin secretion involved in cellular response to glucose stimulus |
1: Rattus norvegicus |
Insulin-Secreting Cells |
6 genes: ATG7 | GHRL | GPR27 | HIF1A | NR1H4 | SIRT1
|
1 |
33. |
Dietary Sucrose
|
mitochondrial electron transport, cytochrome c to oxygen
|
Copper
|
[Dietary Sucrose co-treated with Copper deficiency] results in decreased mitochondrial electron transport, cytochrome c to oxygen |
1: Rattus norvegicus |
Islets of Langerhans |
|
1 |
34. |
Dietary Sucrose
|
positive regulation of macrophage activation
|
Copper
|
[Dietary Sucrose co-treated with Copper deficiency] results in increased positive regulation of macrophage activation |
1: Rattus norvegicus |
Pancreas, Exocrine |
2 genes: HAVCR2 | LBP
|
1 |
35. |
Dietary Sucrose
|
positive regulation of macrophage chemotaxis
|
Copper
|
[Dietary Sucrose co-treated with Copper deficiency] results in increased positive regulation of macrophage chemotaxis |
1: Rattus norvegicus |
Pancreas, Exocrine |
1 gene: CCL2
|
1 |
36. |
Dietary Sucrose
|
positive regulation of insulin secretion involved in cellular response to glucose stimulus
|
Copper
|
Copper inhibits the reaction [[Dietary Sucrose co-treated with Copper deficiency] results in decreased positive regulation of insulin secretion involved in cellular response to glucose stimulus] |
1: Rattus norvegicus |
Insulin-Secreting Cells |
6 genes: ATG7 | GHRL | GPR27 | HIF1A | NR1H4 | SIRT1
|
1 |
37. |
Dietary Sucrose
|
mitochondrial electron transport, cytochrome c to oxygen
|
Copper
|
Copper inhibits the reaction [[Dietary Sucrose co-treated with Copper deficiency] results in decreased mitochondrial electron transport, cytochrome c to oxygen] |
1: Rattus norvegicus |
Islets of Langerhans |
|
1 |
38. |
Dietary Sucrose
|
positive regulation of macrophage activation
|
Copper
|
Copper inhibits the reaction [[Dietary Sucrose co-treated with Copper deficiency] results in increased positive regulation of macrophage activation] |
1: Rattus norvegicus |
Pancreas, Exocrine |
2 genes: HAVCR2 | LBP
|
1 |
39. |
Dietary Sucrose
|
positive regulation of macrophage chemotaxis
|
Copper
|
Copper inhibits the reaction [[Dietary Sucrose co-treated with Copper deficiency] results in increased positive regulation of macrophage chemotaxis] |
1: Rattus norvegicus |
Pancreas, Exocrine |
1 gene: CCL2
|
1 |
40. |
Dietary Sucrose
|
lipid catabolic process
|
Copper
|
[Copper deficiency co-treated with Dietary Sucrose] results in increased lipid catabolic process |
1: Rattus norvegicus |
Liver |
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
41. |
Dietary Sucrose
|
lipid catabolic process
|
Copper
|
[Copper deficiency co-treated with Dietary Sucrose] results in increased lipid catabolic process |
1: Rattus norvegicus |
Serum |
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
42. |
Dietary Sucrose
|
lipid catabolic process
|
Dietary Fats
|
[Dietary Fats co-treated with Dietary Sucrose] results in increased lipid catabolic process |
1: Mus musculus |
Liver |
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
43. |
Dietary Sucrose
|
lipid catabolic process
|
Dietary Fats
| GPX4
|
GPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased lipid catabolic process] |
1: Mus musculus |
Liver |
16 genes: APOA4 | CLPS | CYP39A1 | ENPP6 | LIPF | MGLL | PCK1 | PLA1A | PLA2G10 | PLA2G7 | PLCD4 | PLCXD2 | PLIN1 | PNLIP | PNPLA2 | PRDX6
|
1 |
44. |
Dietary Sucrose
|
positive regulation of vasculogenesis
|
Dietary Fats
|
[Dietary Fats co-treated with Dietary Sucrose] results in decreased positive regulation of vasculogenesis |
1: Macaca mulatta |
Neocortex |
|
1 |
45. |
Dietary Sucrose
|
positive regulation of vasculogenesis
|
Dietary Fats
| Resveratrol
|
Resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased positive regulation of vasculogenesis] |
1: Macaca mulatta |
Neocortex |
|
1 |
46. |
Dietary Sucrose
|
lipid oxidation
|
Dietary Fats
|
[Dietary Fats co-treated with Dietary Sucrose] results in increased lipid oxidation |
1: Mus musculus |
Liver |
1 gene: PLA2G7
|
1 |
47. |
Dietary Sucrose
|
lipid oxidation
|
Dietary Fats
| Thiobarbituric Acid Reactive Substances
|
[[Dietary Fats co-treated with Dietary Sucrose] results in increased lipid oxidation] which results in increased abundance of Thiobarbituric Acid Reactive Substances |
1: Mus musculus |
Liver |
1 gene: PLA2G7
|
1 |
48. |
Dietary Sucrose
|
positive regulation of adipose tissue development
|
Dietary Fats
|
[Dietary Fats co-treated with Dietary Sucrose] results in increased positive regulation of adipose tissue development |
1: Mus musculus |
Intra-Abdominal Fat |
3 genes: GHRL | NR1H4 | SIRT1
|
1 |
49. |
Dietary Sucrose
|
lipid oxidation
|
Dietary Fats
| Quercetin
|
Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased lipid oxidation] |
1: Mus musculus |
Liver |
1 gene: PLA2G7
|
1 |
50. |
Dietary Sucrose
|
lipid oxidation
|
Dietary Fats
| Quercetin
| Thiobarbituric Acid Reactive Substances
|
Quercetin inhibits the reaction [[[Dietary Fats co-treated with Dietary Sucrose] results in increased lipid oxidation] which results in increased abundance of Thiobarbituric Acid Reactive Substances] |
1: Mus musculus |
Liver |
1 gene: PLA2G7
|
1 |