Estradiol

Name	Estradiol
CAS Type 1 Name	Estra-1,3,5(10)-triene-3,17-diol (17beta)-
Equivalent Terms	17 beta Estradiol \| 17 beta-Estradiol \| 17 beta Oestradiol \| 17 beta-Oestradiol \| Aerodiol \| Estrace \| Estraderm TTS \| Estradiol, (16 alpha,17 alpha)-Isomer \| Estradiol, (16 alpha,17 beta)-Isomer \| Estradiol 17 alpha \| Estradiol-17 alpha \| Estradiol, (17-alpha)-Isomer \| Estradiol 17beta \| Estradiol 17 beta \| Estradiol-17beta \| Estradiol-17 beta \| Estradiol, (8 alpha,17 beta)-Isomer \| Estradiol, (8 alpha,17 beta)-(+-)-Isomer \| Estradiol, (9 beta,17 alpha)-Isomer \| Estradiol, (9 beta,17 beta)-Isomer \| Estradiol Hemihydrate \| Estradiol Hemihydrate, (17 alpha)-Isomer \| Estradiol, (-)-Isomer \| Estradiol, (+-)-Isomer \| Estradiol Monohydrate \| Estradiol, Monosodium Salt \| Estradiol Orion Brand \| Estradiol, Sodium Salt \| Novartis Pharmaceuticals Brand of Estradiol \| Oestradiol \| Orion Brand of Estradiol \| Ovocyclin \| Vivelle
CAS Registry Number	50-28-2
Definition	Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.
Structure
Top Interacting Genes
MeSH^® ID	D004958
Additional Links	CCRIS 50-28-2 ChEBI 50-28-2 ChemIDplus^® 50-28-2 DrugBank DB00783 GENE-TOX 50-28-2 Household Products Database 50-28-2 HSDB^® 50-28-2 PubChem D004958 TOXLINE^® Query

Top ↑ Ancestors

1.	Chemicals ← Polycyclic Compounds ← Steroids ← Estranes ← Estrenes ← Estradiol
2.	Chemicals ← Hormones, Hormone Substitutes, and Hormone Antagonists ← Hormones ← Gonadal Hormones ← Gonadal Steroid Hormones ← Estradiol Congeners ← Estradiol

Top ↑ Descendants

Estradiol
	10-hydroxy-17-butoxy-1,3,5(10)-estratrien-3-one
	1,11-ethanoestradiol
	11-(2-fluoroethyl)estradiol
	11-(((4-(5,10,15-triphenylporphyrin-20-yl)phenyl)carbonylamino)butanoyloxy)estradiol
	11 beta-(1-aziridinylmethyl)estradiol
	11beta-bromoacetamidoethoxyphenylE2 estradiol
	11beta-bromoacetamidopentoxyphenylE2 estradiol
	11-beta-chloromethyl-estradiol
	11beta-perfluorohexylestradiol
	11-bromomethyl-estradiol
	11-dehydro-3,17 alpha-estradiol
	11-ethyl-16-fluoroestradiol
	11-ethyl-17-methylestradiol
	11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol
	11-fluoro-7-(5-(methyl(3-((4,4,5,5,5-pentafluoropentyl)sulfanyl)propyl)amino)pentyl)estra-1,3,5(10)-triene-3,17-diol
	11-fluoro-7-(5-(methyl(7,7,8,8,9,9,10,10,10-nonafluorodecyl)amino)pentyl)estra-1,3,5(10)-triene-3,17-diol
	11-methoxy-16-fluoroestradiol
	11-methoxy-16-iodoestradiol
	11-methoxy-4,16-difluoroestradiol
	1-(2-chloroethyl)-1-nitrosocarbamoylalanine estradiol-17-ester
	12-oxo-9(11)-dehydroestradiol
	1,3,5(10)-estratriene-3,17beta-diol 17-hemisuccinate
	1,3,5-estratriene-3,17beta-diol 17-hemisuccinate
	14,15-methylene estradiol
	14-hydroxyestradiol
	15 alpha-hydroxyestradiol
	15 alpha-hydroxyestradiol 3-sulfate
	16 alpha-bromo-11 beta-methoxy-17 beta-estradiol
	16 alpha-bromo-17 beta-estradiol
	16 alpha-bromoacetoxyestradiol-3-methyl ether
	16 alpha-cyanoestradiol 3-methyl ether
	16 alpha-iodoestradiol
	16beta-aminopropyl estradiol
	16 beta-ethylestradiol-17 beta
	16-fluoroestradiol
	16-fluoroestradiol-3,17-disulfamate
	16-formylestradiol
	16-hydroxymethylestra-1,3,5(10)-triene-3,17-diol
	16-iodo-11-methoxyestradiol
	16-ketoestradiol
	16-methoxyestradiol
	16-methylene estradiol
	16-oxoestradiol 3-sulfate
	17-(2-iodovinyl)-11-chloromethylestradiol
	17-(3-((2-phenylquinolin-4-yl)carbonyloxy)propynyl)estradiol
	17 alpha-cyanomethylestradiol 3-methyl ether
	17 alpha-estradiol-3-galacturonide
	17 alpha-ethyl-5 xi-estrane-3 xi,17 beta-diol
	17 alpha-iodovinyl-11 beta-methoxyestradiol
	17 alpha-iodovinylestradiol
	17 alpha-n-butylestradiol-3-cyclopentyl ether
	17-benzylestradiol 3-O-sulfamate
	17 beta-(arylazido-beta-alanine)estradiol-3-methyl ether
	17 beta-estradiol 3-tetrahydropyranyl ether
	17 beta-estradiol hemisuccinate
	17beta-estradiol platinum(II)
	17-bromoacetamidopropylestradiol
	17-butoxy-1,3,5(10)-estratrien-3-ol
	17-desoxyestradiol
	17-dioxanylestradiol
	17-estradiol cyclooctyl acetate
	17-estradiol hydroxypropylcyclodextrin complex
	17-ethylestradiol
	17-ethynyl-16-fluoroestradiol
	17-glucuronosylestradiol
	17-hydroxy-3-methoxy-14,15-methylen-estra-1,3,5(a)-trien
	17-hydroxyestra-1,3,5(10)-trien-3-ylmethanesulfonic acid
	17-iodoacetoxyestradiol-3-sulfate
	17-iodovinyl-11-ethylestradiol
	17-iodovinyl-11-methoxyestradiol-3-methyl ether
	17-iodovinylestradiol-3-methyl ether
	17-methylestradiol
	17-(N,N,-dimethylhydrazinocarbonyloxy)estra-1,3,5(10)-trien-3-ol
	17-(tert-butylbenzyl)estradiol 3-O-sulfamate
	18-fluoro-17-estradiol
	18-methylestradiol-3-methyl ether
	1a-(4-(3-benzoyloxy-1,3,5(10)-estratrien-17-yloxycarbonyl)butyryl)mitomycin C
	1a-(4-(3-hydroxy-1,3,5(10)-estratrien-17-yloxycarbonyl)butyryl)mitomycin C
	1-bromoestradiol
	1-chloroestradiol
	1-fluoroestradiol
	21-(2-(N,N-dimethylamino)ethyl)oxy-7a-methyl-19-norpregna-1,3,5(10),17(20)-tetraen-3-ol
	21-((4-amino)phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17-diol
	2,14-dihydroxyestradiol
	21-chloro-21-iodovinylestradiol
	21-iodo-11-nitrato-19-norpregna-1,3,5(10),20-tetraene-3,17-diol
	2,4-dibromo-17-acetylestradiol
	2,4-dibromo-17-estradiol
	2,4-dibromo-17-iodovinylestradiol
	2,4-dibromoestra-1,3,5(10),6-tetraene-3,17-diol diacetate
	2,4-dichloro-17-iodovinylestradiol
	2,4-dimethyl-17-iodovinylestradiol
	2-chloroestradiol
	2-ethoxyestradiol
	2-ethylestradiol sulfamate
	2-ethyloestradiol-bis-sulfamate
	2-fluoro-4-hydroxyestradiol
	2-fluoroestradiol
	2-fluoroethoxyestradiol
	2-fluoropropanoxyestradiol
	2-hydroxy-3-deoxyestradiol
	2-hydroxy-3-methoxyestradiol
	2-hydroxy-4-glutathion-S-yl-17 beta-estradiol
	2-hydroxyestradiol
	2-hydroxyestradiol-17-glucuronide
	2-hydroxyestradiol 17-sulfate
	2-hydroxyestradiol-2,3-dibenzoate
	2-hydroxyestradiol 2,3-methylene ether
	2-iodoestradiol
	2-methoxy-17-cyanomethylestra-1,3,5(10)-trien-3-ol
	2-methoxy-7alpha-methylestradiol
	2-methoxyestradiol
	2-methoxyestradiol 17-phosphate
	2-methoxyestradiol-3,17-bis-O,O-sulfamate
	2-methoxyestradiol 3,17-diphosphate
	2-methoxyestradiol 3-phosphate
	2-methoxyestradiol sulfamate
	2-methoxymethylestradiol
	2-methoxyoestradiol
	2-methylestradiol
	3,17-diacetoxyestra-1,3,5(10)-trien-2-carboxylic acid
	3,17-dihydroxyestra-1,3,5(10)-trien-15-yl-2'-acetamido-2'-deoxyglucopyranoside
	3,17-dihydroxyestra-1,3,5(10)-triene 6-N-(epsilon-biotinyl)caproamide
	3-(2-iodobenzoyl)estradiol
	3-(3',17'-dihydroxyestra-1',3',5'(10')-trien-16'-methyl)benzamide
	3-acetyl-estradiol
	3-deoxyestradiol 17-sulfate
	3-methoxyestradiol
	3-propoxy-17-methoxyestradiol
	4,6 beta-ethanoestradiol
	4-amino-N-fluorescein isothiocyanate-17-estradiol
	4-azidoestradiol
	4-chloroestradiol
	4-fluoro-2-hydroxyestradiol
	4-fluoroestradiol
	4-hydroxy-2-methylestradiol
	4-hydroxyestradiol 17-sulfate
	4-hydroxyestradiol-2-N-acetylcysteine
	4-hydroxyestradiol-3,4-dibenzoate
	4-mercuriestradiol
	4-methoxyestradiol
	4-methylestradiol
	6-((2'-aminoethyl)carboxamidoethyl)estradiol
	6-(5-azido-2-nitrobenzoyl)amidoestradiol
	6-aminoestradiol
	6-hydroxyestradiol 17-sulfate
	6-iodo-1,3,5(10),6-tetraene-3,17 beta-diol
	6-ketoestradiol
	6-methoxy-7-bromoestradiol
	7-(11-(4-iodophenoxy)undecyl)-17-estradiol
	7-(3'-carboxypropyl)estradiol
	7-(4,8,12-trimethyltridecyl)estra-1,3,5-trien-3,17-diol
	7-(5-(4,4-difluoro-5,7-dimethyl-4-bora-3,4-diaza-3-indacenepropionyl)aminopentyl)estradiol
	7-(5-fluoropentyl)estradiol
	7alpha-methyl ethinylestradiol
	7-hydroxyestradiol 17-sulfate
	7-thiophenylestradiol
	abeo-estradiol
	alfatradiol
	benzo(d,e)estra-1,3,5(10)-triene-3,17 beta-diol 17-acetate
	bestrabucil
	caprovestrol
	CD-37 compound
	CH 4893237
	cis-diamino(2-(4-(17alpha-ethynylestradiolyl)-benzoylamino)-malonato)platinum
	cis-dichloro(N-(4-(17alpha-ethynylestradiolyl)-benzyl)-ethylenediamine)platinum
	CycloProvera
	Cyklabil
	deladroxate
	delta(9(11))-dehydro-17beta-estradiol
	diestradiol
	divina
	EBCO
	EM 139
	EM-1745
	estra-1,3,5(10),6-tetraene-3,17-diol
	estra-5(10),6,8-triene-3,17-diol
	estra-5(10),7-diene-3,17-diol
	estradiol-16
	estradiol 17-acetate
	estradiol 17-acetylglucosaminide
	estradiol-17-arachidonate
	estradiol-17-benzoate
	estradiol-17beta 3-carboranylmethyl ether
	estradiol-17-beta-3-hemisuccinyl-bovine serum albumin
	estradiol-17 beta-3-methyl ether
	estradiol-17 beta-benzoate
	estradiol 17 beta-cypionate
	estradiol-17 beta-decanoate
	estradiol-17 beta-glucuronide
	estradiol-17 beta-succinyl-bovine serum albumin
	estradiol 17-butyrate
	estradiol 17-dihydrotrigonelline
	estradiol-17-glucosiduronate-(C-6)-bovine serum albumin conjugate
	estradiol 17-hemisuccinate-bovine serum albumin-fluorescein isothiocyanate
	estradiol-17-O-hemiglutarate
	estradiol 17-palmitate
	estradiol-17-phenylpropionate
	estradiol-17-stearate
	estradiol 17-sulfate
	estradiol 17-undecanoate
	estradiol-2,3-O-quinone
	estradiol-3,17-diacetate
	estradiol 3,17-disulfate
	estradiol-3,4-quinone
	estradiol 3-benzoate
	estradiol-3-benzoate-17-n-butyrate
	estradiol-3-dansylate
	estradiol-3-glucoside
	estradiol-3-glucuronide
	estradiol-3-O-carboxymethyl ether
	estradiol-3-O-sulfamate
	estradiol 3-propyl ether
	estradiol-3-sulfate
	estradiol-3-trimethylsilyl ether-17-heptafluorobutyrate
	estradiol-3-xyloside
	estradiol-6-(O-carboxymethyl)oxime
	estradiol 6-O-carboxymethyloxime-bovine serum albumin-fluorescein isothiocyanate
	estradiol-6-oxime
	estradiol benzoate, estradiol dienanthate, testosterone enantate drug combination
	estradiol benzoate, estradiol phenylpropionate, testosterone phenylpropionate, testosterone propionate drug combination
	estradiol benzoate, progesterone drug combination
	estradiol benzoate, testosterone propionate drug combination
	estradiol bis(tert-butyldimethylsilyl)ether
	estradiol-bovine serum albumin
	estradiol-bovine serum albumin-biotin
	estradiol dienanthate
	estradiol dipropionate
	estradiol-drospirenone combination
	estradiol (E(2))-Asp-hexapeptide conjugate
	estradiol enanthate
	estradiol, estriol drug combination
	estradiol hexahydrobenzoate
	estradiol nitrate
	estradiol, norethindrone drug combination
	estradiol, norethisterone, testosterone drug combination
	estradiol ruthenocenecarboxylate
	estradiol sulfate
	estradiol valerate
	estradiol valerate, cyproterone acetate drug combination
	estradiol valerate-dienogest
	estradiol Valerate, dienogest drug combination
	estradiol valerate, testosterone enantate drug combination
	Estramustine
	estrapronicate
	estredox
	estrynamine
	ethyl (3,17-dihydroxyestra-1,3,5(10)-triene-11-yl)acetate
	ethylenestradiol
	etrosteron
	femoston
	fulvestrant
	gravibinian
	Gynodian
	hexestrol-3',4'-quinone
	HMR 3339
	homoestradiol
	hormonin
	ICI 164384
	Implix
	Injectable No. 1
	J811 scavestrogen
	J861 scavestrogen
	klimaxil
	klimonorm
	KW 2581
	LE(2)
	Lunelle
	Malun 25
	methyl (3,17-dihydroxyestra-1,3,5(10)-triene-11-yl)acetate
	N(2)-(estradiol-6-yl)-2'-deoxyguanosine
	N-butyl-2-(5-(4-(3,17-dihydroxyestra-1,3,5(10)-trien-11-yl)phenoxy)pentylthio)-N-methylacetamide
	N-butyl-N-methyl-7-(3',17'beta-dihydroxy-1',3',5'(10')-estratriene-6'beta-yl)-7-thiaheptanamide
	N-butyl,N-methyl-8-(3',17'-dihydroxyestra-1',3',5'(10')-trien-17'-yl)-7-octynamide
	netagen
	N-fluoresceino-N'(17 beta-(estradiol-hemisuccinamide)-ethyl)-thiourea
	Org 369-2
	O-(saccharinylmethyl)estradiol
	oxabolone cypionate
	Phillips Corona Ointment
	polyestradiol
	polyestradiol phosphate
	primosiston
	promestriene
	Revalor
	RU 39411
	RU 45144
	RU 58668
	SHD 386L
	Syncro-Mate B
	technetium Tc 99m 3,17-estradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid) ester
	tetrakis(3,17-diacetoxyestra-1,3,5(10)-trien-2-carboxylato)dicopper(II)
	trisequence
	Trisequens
	trophobolen
	TS 108
	ZK 115194
	ZK 136295
	ZK253
	ZK703
	ZYC 5