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Chemical Estrenes

1–50 of 1,526 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione cell death Dexamethasone 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [Dexamethasone results in increased cell death] 1: Rattus norvegicus Muscle, Skeletal | Cells, Cultured   1
2. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione calcium-mediated signaling Histamine 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Histamine results in increased calcium-mediated signaling] 1: Homo sapiens Bone and Bones | Cell Line, Tumor
4 genes: EDN1 | EDNRB | PLCG1 | TNF 		1
3. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione calcium-mediated signaling Histamine 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Histamine results in increased calcium-mediated signaling] 1: Homo sapiens Osteoblasts
4 genes: EDN1 | EDNRB | PLCG1 | TNF 		1
4. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione calcium-mediated signaling Clodronic Acid 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Clodronic Acid results in increased calcium-mediated signaling] 1: Homo sapiens Thyroid Gland | Cell Line, Tumor
4 genes: EDN1 | EDNRB | PLCG1 | TNF 		1
5. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione calcium-mediated signaling Adenosine Triphosphate 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased calcium-mediated signaling] 1: Homo sapiens Thyroid Gland | Cell Line, Tumor
4 genes: EDN1 | EDNRB | PLCG1 | TNF 		1
6. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione cell proliferation OXT | OXTR 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[OXT protein binds to and results in increased activity of OXTR protein] which results in decreased cell proliferation] HEK293 Cells
5 genes: AKT1 | CHRM1 | EGFR | GCG | SRC 		1
7. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione apoptotic process Pilocarpine 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased apoptotic process] 1: Homo sapiens Skin | Fibroblasts
10 genes: ADRA1A | AKT1 | CASP3 | CASR | CCK | IL1B | MAPK1 | MAPK3 | PRKCA | TNF 		1
8. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione calcium-mediated signaling 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects calcium-mediated signaling 1: Mus musculus Testis | Arteries | Muscle, Smooth, Vascular
4 genes: EDN1 | EDNRB | PLCG1 | TNF 		1
9. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione negative regulation of phospholipase C activity 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects negative regulation of phospholipase C activity 1: Homo sapiens Prostate | Cell Line, Tumor   1
10. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration Eugenol 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Eugenol results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens Neuroglia | Cell Line, Tumor
11 genes: ADRA1A | AGT | EDN1 | EDNRB | IL1B | KNG1 | OXT | OXTR | TAC1 | TRPC6 | TRPV1 		1
11. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione regulation of calcium ion transport Smoke 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Smoke analog affects regulation of calcium ion transport] 1: Homo sapiens Endothelial Cells | Cell Line
3 genes: AGT | CASR | RHOA 		1
12. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione regulation of cytosolic calcium ion concentration bisphenol A 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [bisphenol A affects regulation of cytosolic calcium ion concentration] 1: Canis lupus familiaris Madin Darby Canine Kidney Cells
2 genes: F2 | PLCD1 		1
13. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Quercetin 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Quercetin results in increased positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] 1: Homo sapiens Hepatocytes | Cell Line, Tumor
2 genes: EDN1 | PLCD1 		1
14. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway epigallocatechin gallate 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [epigallocatechin gallate results in increased positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] 1: Homo sapiens Hepatocytes | Cell Line, Tumor
2 genes: EDN1 | PLCD1 		1
15. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 3,3',4,5'-tetrahydroxystilbene 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,3',4,5'-tetrahydroxystilbene results in increased positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] 1: Homo sapiens Hepatocytes | Cell Line, Tumor
2 genes: EDN1 | PLCD1 		1
16. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Resveratrol 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Resveratrol results in increased positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] 1: Homo sapiens Hepatocytes | Cell Line, Tumor
2 genes: EDN1 | PLCD1 		1
17. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of CREB transcription factor activity Epinephrine 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased positive regulation of CREB transcription factor activity] 1: Rattus norvegicus PC12 Cells   1
18. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione calcium ion homeostasis Adenosine Triphosphate 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate affects calcium ion homeostasis] 1: Homo sapiens Brain | Cell Line, Tumor
2 genes: CASR | GNAS 		1
19. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione calcium ion homeostasis Gallic Acid 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Gallic Acid affects calcium ion homeostasis] 1: Homo sapiens Brain | Cell Line, Tumor
2 genes: CASR | GNAS 		1
20. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration Resveratrol 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Resveratrol results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens Mouth | Cell Line, Tumor
11 genes: ADRA1A | AGT | EDN1 | EDNRB | IL1B | KNG1 | OXT | OXTR | TAC1 | TRPC6 | TRPV1 		1
21. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of membrane depolarization KNG1 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein modified form results in increased positive regulation of membrane depolarization] 1: Homo sapiens HEK293 Cells   1
22. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration Uridine Triphosphate 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Uridine Triphosphate results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens HEK293 Cells
11 genes: ADRA1A | AGT | EDN1 | EDNRB | IL1B | KNG1 | OXT | OXTR | TAC1 | TRPC6 | TRPV1 		1
23. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of cytosolic calcium ion concentration KNG1 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein modified form results in increased positive regulation of cytosolic calcium ion concentration] 1: Bos taurus Adrenal Medulla | Chromaffin Cells | Cells, Cultured
11 genes: ADRA1A | AGT | EDN1 | EDNRB | IL1B | KNG1 | OXT | OXTR | TAC1 | TRPC6 | TRPV1 		1
24. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione release of sequestered calcium ion into cytosol TFLLRNPNDK-NH2 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [TFLLRNPNDK-NH2 results in increased release of sequestered calcium ion into cytosol] 1: Homo sapiens Blood Platelets
2 genes: TRPA1 | TRPV1 		1
25. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione release of sequestered calcium ion into cytosol alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine results in increased release of sequestered calcium ion into cytosol] 1: Homo sapiens Blood Platelets
2 genes: TRPA1 | TRPV1 		1
26. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione platelet aggregation F2 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [F2 protein results in increased platelet aggregation] 1: Homo sapiens Blood 1 gene: GNAS 1
27. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione platelet aggregation TFLLRNPNDK-NH2 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [TFLLRNPNDK-NH2 results in increased platelet aggregation] 1: Homo sapiens Blood 1 gene: GNAS 1
28. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione platelet aggregation alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine results in increased platelet aggregation] 1: Homo sapiens Blood 1 gene: GNAS 1
29. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of vasoconstriction Acetylcholine 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Acetylcholine results in increased positive regulation of vasoconstriction] 1: Rattus norvegicus Umbilical Veins
6 genes: ADRA1A | AKT1 | CASR | EGFR | PTGS2 | RHOA 		1
30. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione positive regulation of calcium ion import across plasma membrane bisphenol A 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [bisphenol A results in increased positive regulation of calcium ion import across plasma membrane] 1: Rattus norvegicus Testis   1
31. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione cell proliferation Roxarsone 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Roxarsone results in increased cell proliferation] 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured
5 genes: AKT1 | CHRM1 | EGFR | GCG | SRC 		1
32. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione cell proliferation 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased cell proliferation 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured
5 genes: AKT1 | CHRM1 | EGFR | GCG | SRC 		1
33. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione wound healing, spreading of cells Roxarsone 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Roxarsone results in increased wound healing, spreading of cells] 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured 1 gene: RHOA 1
34. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione wound healing, spreading of cells 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased wound healing, spreading of cells 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured 1 gene: RHOA 1
35. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione cell growth 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased cell growth 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured   1
36. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione cell growth Roxarsone 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Roxarsone results in increased cell growth] 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured   1
37. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione angiogenesis Roxarsone 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Roxarsone results in increased angiogenesis] 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured
6 genes: JUN | LEP | PLCD1 | PLCG1 | PRKCA | PTGS2 		1
38. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione angiogenesis 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased angiogenesis 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured
6 genes: JUN | LEP | PLCD1 | PLCG1 | PRKCA | PTGS2 		1
39. 16-hydroxyestrone estrogen biosynthetic process Fingolimod Hydrochloride [Fingolimod Hydrochloride affects estrogen biosynthetic process] which results in decreased secretion of 16-hydroxyestrone 1: Homo sapiens Prostate | Cell Line, Tumor   1
40. 17-dihydroequilenin lipoprotein oxidation 17-dihydroequilenin results in decreased lipoprotein oxidation 1: Homo sapiens Plasma   1
41. 2-hydroxyestradiol positive regulation of cell proliferation 2-hydroxyestradiol affects positive regulation of cell proliferation 1: Homo sapiens Prostate | Epithelial Cells | Cell Line
4 genes: AR | CCND1 | MYC | PTGS2 		1
42. 2-hydroxyestradiol negative regulation of intracellular estrogen receptor signaling pathway 2-hydroxyestradiol affects negative regulation of intracellular estrogen receptor signaling pathway 1: Homo sapiens Prostate | Epithelial Cells | Cell Line   1
43. 2-hydroxyestradiol positive regulation of dopamine receptor signaling pathway 2-hydroxyestradiol results in increased positive regulation of dopamine receptor signaling pathway Corpus Striatum   1
44. 2-Methoxyestradiol apoptotic process 2-Methoxyestradiol results in increased apoptotic process 1: Homo sapiens Jurkat Cells
10 genes: AKT1 | BAD | BCL2 | CASP3 | CASP7 | CASP8 | CASP9 | CDK1 | PARP1 | XIAP 		1
45. 2-Methoxyestradiol apoptotic process TYMP TYMP inhibits the reaction [2-Methoxyestradiol results in increased apoptotic process] 1: Homo sapiens Jurkat Cells
10 genes: AKT1 | BAD | BCL2 | CASP3 | CASP7 | CASP8 | CASP9 | CDK1 | PARP1 | XIAP 		1
46. 2-Methoxyestradiol cell proliferation 2-Methoxyestradiol results in decreased cell proliferation 1: Homo sapiens Aorta | Myocytes, Smooth Muscle
11 genes: AKT1 | BAD | BCL2 | CDC25C | CDK1 | CDK4 | CTF1 | CTNNB1 | CYP1A1 | NANOG | VEGFA 		1
47. 2-Methoxyestradiol apoptotic process 2-Methoxyestradiol results in increased apoptotic process 1: Homo sapiens Aorta | Myocytes, Smooth Muscle
10 genes: AKT1 | BAD | BCL2 | CASP3 | CASP7 | CASP8 | CASP9 | CDK1 | PARP1 | XIAP 		1
48. 2-Methoxyestradiol apoptotic process Thymidine Thymidine inhibits the reaction [2-Methoxyestradiol results in increased apoptotic process] 1: Homo sapiens Aorta | Myocytes, Smooth Muscle
10 genes: AKT1 | BAD | BCL2 | CASP3 | CASP7 | CASP8 | CASP9 | CDK1 | PARP1 | XIAP 		1
49. 2-Methoxyestradiol cell cycle 2-Methoxyestradiol results in decreased cell cycle 1: Homo sapiens Aorta | Myocytes, Smooth Muscle
11 genes: CCNA2 | CCNB1 | CCND1 | CCND3 | CCNE2 | CDC25C | CDK1 | CDK2 | CDK4 | CDKN1B | H2AFX 		1
50. 2-Methoxyestradiol regulation of membrane permeability Glucose 2-Methoxyestradiol inhibits the reaction [Glucose affects regulation of membrane permeability] 2: Homo sapiens | Mus musculus Brain | Microvessels | Endothelial Cells | Cells, Cultured   1
1–50 of 1,526 results.
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