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Chemical Factor XII

Name Factor XII
CAS Type 1 Name Blood-coagulation factor XII
Equivalent Terms Coagulation Factor XII | Hageman Factor
CAS Registry Number 9001-30-3
Definition Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D005174
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ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Blood Coagulation Factors Has associated genes Has associated diseases Has associated exposure references Factor XII

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Factor XII
  Factor XIIa
  factor XII Bern
  factor XII Locarno
  factor XII Mie-1, human
  factor XII Toronto
  factor XII Washington D.C.