1. |
1-methylguanine
|
DNA dealkylation involved in DNA repair
|
ALKBH2
|
[ALKBH2 protein results in increased DNA dealkylation involved in DNA repair] which results in decreased abundance of 1-methylguanine |
1: Homo sapiens |
|
|
1 |
2. |
7-methylguanine
|
DNA damage response, detection of DNA damage
|
Temozolomide
|
[Temozolomide results in increased DNA damage response, detection of DNA damage] which results in increased abundance of 7-methylguanine |
1: Homo sapiens |
|
|
1 |
3. |
7-methylguanine
|
DNA methylation
|
Temozolomide
|
[Temozolomide results in increased DNA methylation] which results in increased abundance of 7-methylguanine |
1: Homo sapiens |
|
|
1 |
4. |
8-nitroguanine
|
DNA modification
|
Asbestos, Amphibole
|
[Asbestos, Amphibole results in increased DNA modification] which results in increased abundance of 8-nitroguanine |
1: Homo sapiens |
Lung |
|
1 |
5. |
8-nitroguanine
|
depurination
|
Arsenicals
| reactive nitrogen species metabolic process
|
[[Arsenicals results in increased reactive nitrogen species metabolic process] which results in increased depurination] which results in increased abundance of 8-nitroguanine |
1: Homo sapiens |
Urine |
|
1 |
6. |
8-nitroguanine
|
reactive nitrogen species metabolic process
|
Arsenicals
| depurination
|
[[Arsenicals results in increased reactive nitrogen species metabolic process] which results in increased depurination] which results in increased abundance of 8-nitroguanine |
1: Homo sapiens |
Urine |
|
1 |
7. |
Acyclovir
|
membrane lipid catabolic process
|
Quinolinic Acid
|
Acyclovir inhibits the reaction [Quinolinic Acid results in increased membrane lipid catabolic process] |
1: Rattus norvegicus |
Brain |
|
1 |
8. |
Acyclovir
|
post-embryonic eye morphogenesis
|
|
Acyclovir results in decreased post-embryonic eye morphogenesis |
1: Rattus norvegicus |
Eye |
|
1 |
9. |
Acyclovir
|
serotonin catabolic process
|
|
Acyclovir results in decreased serotonin catabolic process |
1: Rattus norvegicus |
Prosencephalon |
|
1 |
10. |
Acyclovir
|
serotonin catabolic process
|
Serotonin
|
[Acyclovir results in decreased serotonin catabolic process] which results in increased abundance of Serotonin |
1: Rattus norvegicus |
Prosencephalon |
|
1 |
11. |
Acyclovir
|
serotonin catabolic process
|
Hydroxyindoleacetic Acid
|
[Acyclovir results in decreased serotonin catabolic process] which results in decreased chemical synthesis of Hydroxyindoleacetic Acid |
1: Rattus norvegicus |
Prosencephalon |
|
1 |
12. |
Acyclovir
|
indole-containing compound metabolic process
|
|
Acyclovir affects indole-containing compound metabolic process |
1: Rattus norvegicus |
Prosencephalon |
|
1 |
13. |
Acyclovir
|
indole-containing compound metabolic process
|
Hydroxyindoleacetic Acid
|
[Acyclovir affects indole-containing compound metabolic process] which affects the metabolism of and results in increased abundance of Hydroxyindoleacetic Acid |
1: Rattus norvegicus |
Prosencephalon |
|
1 |
14. |
aflatoxin-B1-N7-guanine
|
glutathione transferase activity
|
Aflatoxin B1
| sulforafan
|
[sulforafan results in increased glutathione transferase activity] inhibits the reaction [Aflatoxin B1 results in increased abundance of aflatoxin-B1-N7-guanine] |
1: Rattus norvegicus |
Liver |
|
1 |
15. |
Azaguanine
|
cell death
|
|
Azaguanine results in increased cell death |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
16. |
Ganciclovir
|
germ cell development
|
|
Ganciclovir results in decreased germ cell development |
1: Rattus norvegicus |
Testis |
|
1 |
17. |
Ganciclovir
|
developmental process involved in reproduction
|
|
Ganciclovir results in decreased developmental process involved in reproduction |
1: Rattus norvegicus |
|
|
1 |
18. |
Ganciclovir
|
negative regulation of male gonad development
|
|
Ganciclovir results in increased negative regulation of male gonad development |
1: Rattus norvegicus |
Testis |
|
1 |
19. |
Ganciclovir
|
seminiferous tubule development
|
|
Ganciclovir results in decreased seminiferous tubule development |
1: Rattus norvegicus |
Seminiferous Tubules | Germ Cells |
|
1 |
20. |
Ganciclovir
|
germ cell development
|
|
Ganciclovir results in decreased germ cell development |
1: Rattus norvegicus |
Seminiferous Tubules | Germ Cells |
|
1 |
21. |
Ganciclovir
|
Sertoli cell proliferation
|
|
Ganciclovir results in decreased Sertoli cell proliferation |
1: Rattus norvegicus |
Sertoli Cells |
|
1 |
22. |
Ganciclovir
|
Sertoli cell development
|
|
Ganciclovir results in decreased Sertoli cell development |
1: Rattus norvegicus |
Sertoli Cells |
|
1 |
23. |
Guanine
|
DNA-dependent DNA replication maintenance of fidelity
|
|
Guanine metabolite results in decreased DNA-dependent DNA replication maintenance of fidelity |
1: Homo sapiens |
|
|
1 |
24. |
Guanine
|
DNA-dependent DNA replication maintenance of fidelity
|
REV1
|
REV1 protein inhibits the reaction [Guanine metabolite results in decreased DNA-dependent DNA replication maintenance of fidelity] |
1: Homo sapiens |
|
|
1 |
25. |
N7-(2,3,4-trihydroxybut-1-yl)-guanine
|
DNA modification
|
1,3-butadiene
|
[1,3-butadiene results in increased DNA modification] which results in increased abundance of N7-(2,3,4-trihydroxybut-1-yl)-guanine |
1: Mus musculus |
Lung |
|
1 |
26. |
O(6)-benzylguanine
|
cell cycle
|
mitozolomide
|
[mitozolomide co-treated with O(6)-benzylguanine] results in decreased cell cycle |
1: Homo sapiens |
Brain | Cell Line, Tumor |
7 genes: CDKN1A | CDKN1B | CHEK1 | MLH1 | MSH2 | TP53 | TRP53
|
1 |
27. |
O(6)-benzylguanine
|
cell cycle
|
Temozolomide
|
[Temozolomide co-treated with O(6)-benzylguanine] results in decreased cell cycle |
1: Homo sapiens |
Brain | Cell Line, Tumor |
7 genes: CDKN1A | CDKN1B | CHEK1 | MLH1 | MSH2 | TP53 | TRP53
|
1 |
28. |
O(6)-benzylguanine
|
cell cycle
|
Carmustine
|
[Carmustine co-treated with O(6)-benzylguanine] results in decreased cell cycle |
1: Homo sapiens |
Brain | Cell Line, Tumor |
7 genes: CDKN1A | CDKN1B | CHEK1 | MLH1 | MSH2 | TP53 | TRP53
|
1 |
29. |
O(6)-benzylguanine
|
apoptotic process
|
Dacarbazine
|
O(6)-benzylguanine inhibits the reaction [Dacarbazine results in increased apoptotic process] |
1: Mus musculus |
Intestine, Small | Epithelium |
5 genes: BAX | BCL2 | CHEK1 | TP53 | TRP53
|
1 |
30. |
O(6)-benzylguanine
|
positive regulation of cell death
|
fotemustine
|
O(6)-benzylguanine promotes the reaction [fotemustine results in increased positive regulation of cell death] |
1: Homo sapiens |
Neuroglia | Cell Line, Tumor |
2 genes: CDKN1A | CDKN1B
|
1 |
31. |
O-(6)-methylguanine
|
DNA modification
|
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
|
[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased DNA modification] which results in increased abundance of O-(6)-methylguanine |
1: Mus musculus |
Lung |
|
1 |
32. |
O-(6)-methylguanine
|
DNA modification
|
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
|
[4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol results in increased DNA modification] which results in increased abundance of O-(6)-methylguanine |
1: Mus musculus |
Lung |
|
1 |
33. |
O-(6)-methylguanine
|
DNA modification
|
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
| 7,8-dihydromethysticin
|
7,8-dihydromethysticin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased DNA modification] which results in increased abundance of O-(6)-methylguanine] |
1: Mus musculus |
Lung |
|
1 |
34. |
Pemetrexed
|
cell proliferation
|
|
Pemetrexed results in decreased cell proliferation |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
6 genes: ALK | BCL2 | ERCC1 | FPGS | IL1A | TP53
|
1 |
35. |
Pemetrexed
|
cell proliferation
|
gemcitabine
|
Pemetrexed promotes the reaction [gemcitabine results in decreased cell proliferation] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
6 genes: ALK | BCL2 | ERCC1 | FPGS | IL1A | TP53
|
1 |
36. |
Pemetrexed
|
cell cycle
|
gemcitabine
|
[Pemetrexed co-treated with gemcitabine] results in decreased cell cycle |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
4 genes: CCND1 | CDKN1A | DDIT3 | TP53
|
1 |
37. |
Pemetrexed
|
cell proliferation
|
|
Pemetrexed results in decreased cell proliferation |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
6 genes: ALK | BCL2 | ERCC1 | FPGS | IL1A | TP53
|
1 |
38. |
Pemetrexed
|
apoptotic process
|
Cisplatin
|
[Pemetrexed co-treated with Cisplatin] results in increased apoptotic process |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
39. |
Pemetrexed
|
apoptotic process
|
Cisplatin
| Valproic Acid
|
Valproic Acid promotes the reaction [[Pemetrexed co-treated with Cisplatin] results in increased apoptotic process] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
40. |
Pemetrexed
|
apoptotic process
|
Cisplatin
| Vorinostat
|
Vorinostat promotes the reaction [[Pemetrexed co-treated with Cisplatin] results in increased apoptotic process] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
41. |
Pemetrexed
|
apoptotic process
|
Cisplatin
| Valproic Acid
|
[Pemetrexed co-treated with Cisplatin] promotes the reaction [Valproic Acid results in increased apoptotic process] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
42. |
Pemetrexed
|
apoptotic process
|
Cisplatin
| Vorinostat
|
[Pemetrexed co-treated with Cisplatin] promotes the reaction [Vorinostat results in increased apoptotic process] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
43. |
Pemetrexed
|
cell cycle
|
Cisplatin
|
[Pemetrexed co-treated with Cisplatin] results in decreased cell cycle |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
4 genes: CCND1 | CDKN1A | DDIT3 | TP53
|
1 |
44. |
Pemetrexed
|
cell cycle
|
Cisplatin
| Vorinostat
|
Vorinostat promotes the reaction [[Pemetrexed co-treated with Cisplatin] results in decreased cell cycle] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
4 genes: CCND1 | CDKN1A | DDIT3 | TP53
|
1 |
45. |
Pemetrexed
|
cell cycle
|
Cisplatin
| Valproic Acid
|
Valproic Acid promotes the reaction [[Pemetrexed co-treated with Cisplatin] results in decreased cell cycle] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
4 genes: CCND1 | CDKN1A | DDIT3 | TP53
|
1 |
46. |
Pemetrexed
|
apoptotic process
|
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone
| Cisplatin
|
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Pemetrexed co-treated with Cisplatin] results in increased apoptotic process] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
47. |
Pemetrexed
|
apoptotic process
|
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone
| Cisplatin
|
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Pemetrexed co-treated with Cisplatin] results in increased apoptotic process] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
48. |
Pemetrexed
|
response to oxidative stress
|
Cisplatin
| Valproic Acid
|
[Cisplatin co-treated with Pemetrexed] promotes the reaction [Valproic Acid results in increased response to oxidative stress] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
4 genes: BCL2 | DDIT3 | ERCC1 | TP53
|
1 |
49. |
Pemetrexed
|
apoptotic process
|
Acetylcysteine
| Cisplatin
|
Acetylcysteine inhibits the reaction [[Pemetrexed co-treated with Cisplatin] results in increased apoptotic process] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |
50. |
Pemetrexed
|
apoptotic process
|
Acetylcysteine
| Cisplatin
| Valproic Acid
|
Acetylcysteine inhibits the reaction [Valproic Acid promotes the reaction [[Pemetrexed co-treated with Cisplatin] results in increased apoptotic process]] |
1: Homo sapiens |
Epithelium | Cell Line, Tumor |
12 genes: BCL2 | BID | CFLAR | DDIT3 | FAS | IL1A | MAP2K6 | TNFAIP3 | TNFRSF10B | TNFRSF9 | TP53 | TRAF1
|
1 |