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Chemical Heterocyclic Compounds, 3-Ring

These are exposure studies associated with the chemical and all of its children.

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1–32 of 32 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Hedley AJ, et al. (2006). In a 2002-2003 World Health Organization exposure study, 13 pools of breast milk comprising samples from 316 primiparous women in Hong Kong in 2002 were analyzed by gas chromatography/mass spectrometry for 29 polychlorinated dibenzo-para-dioxins /dibenzofurans and dioxin-like poly-chlorinated biphenyls congeners. 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,4,7,8-hexachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzofuran | 1,2,3,6,7,8-hexachlorodibenzodioxin | 1,2,3,7,8-pentachlorodibenzofuran | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3,4,4'5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3,4,7,8-pentachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran | 3,4,3',4'-tetrachlorobiphenyl | 3,4,5,3',4',5'-hexachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | Benzofurans | octachlorodibenzofuran | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | polychlorodibenzofuran | Tetrachlorodibenzodioxin Mothers Hong Kong milk, human 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,4,7,8-hexachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzofuran | 1,2,3,6,7,8-hexachlorodibenzodioxin | 1,2,3,7,8-pentachlorodibenzofuran | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3,4,4'5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3,4,7,8-pentachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran | 3,4,3',4'-tetrachlorobiphenyl | 3,4,5,3',4',5'-hexachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | Benzofurans | octachlorodibenzofuran | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | polychlorodibenzofuran | Tetrachlorodibenzodioxin Details
2. Lee DH, et al. (2007). National Health and Nutrition Examination Survey (NHANES) This study suggests that the prevalence of a cluster of cardiovascular risk factors relates to background exposure to a mixture of persistent organic pollutants, several of which are also related to the prevalence of diabetes. 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,4,7,8-hexachlorodibenzofuran | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | Dibenzofurans, Polychlorinated | Hydrocarbons, Chlorinated | Pesticides | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins Study subjects United States Details Insulin Resistance | Metabolic Syndrome X | cholesterol metabolic process | regulation of blood pressure | triglyceride metabolic process
3. Pless-Mulloli T, et al. (2005). Long term residency near heavy and chemical industry did not have an effect on women's body burden of polychlorinated dibenzo-dioxins and furans and polychlorinated biphenyls on Teesside, UK. 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzofuran | 1,2,3,6,7,8-hexachlorodibenzodioxin | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3,4,7,8-pentachlorodibenzofuran | Benzofurans | Dibenzofurans, Polychlorinated | octachlorodibenzo-4-dioxin | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Study subjects United Kingdom blood 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzofuran | 1,2,3,6,7,8-hexachlorodibenzodioxin | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3,4,7,8-pentachlorodibenzofuran | Benzofurans | Dibenzofurans, Polychlorinated | octachlorodibenzo-4-dioxin | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Details
4. Wang SL, et al. (2004). This study has provided an indication of polychlorinated biphenyl, polychlorinated dibenzo-p-dioxin, and dibenzofuran body burden from a group of childbearing aged women and their newborns among the general population in central Taiwan. 2,2',3',4,4',5-hexachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dibenzofurans, Polychlorinated | Endocrine Disruptors | PCB 180 | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins Pregnant females Taiwan, Province of China blood | blood, cord | milk, human | placenta Dibenzofurans, Polychlorinated | Endocrine Disruptors | Heterocyclic Compounds | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins Details
5. Fujiyoshi PT, et al. (2006). Air Force Health Study These results show that the mRNA ratio of SLC2A4 to NFKB1 is a reliable marker for the diabetogenic action of dioxin, particularly at very low exposure levels that are not much higher than those found in the general public. Agent Orange Veterans United States adipose tissue | serum Dioxins | NFKB1 | SLC2A4 Details Diabetes Mellitus, Type 2
6. Michalek JE, et al. (2001). We found an increased risk of 'other liver disorders' among veterans with the highest dioxin levels; whether the associations observed were causal is unclear from these data. Agent Orange | Defoliants, Chemical Veterans United States serum Tetrachlorodibenzodioxin Details Liver Diseases
7. Zafar MB, et al. (2001). Agent Orange may have a role in the causation of some types of cancer but we identified no significant relationship of prostate cancer with Agent Orange exposure in patients referred for prostate biopsy. Agent Orange | Defoliants, Chemical Veterans United States Details Prostatic Neoplasms
8. Kern PA, et al. (2004). These data suggest that high blood tetrachlorodibenzodioxin (TCDD) levels, from exposure to Agent Orange, may promote an insulin-resistant state, but the magnitude of this effect appeared to be small, such that an 18-fold increase in blood TCDD resulted in only a 10% change in insulin sensitivity. Agent Orange | Defoliants, Chemical Veterans United States serum Tetrachlorodibenzodioxin Details Insulin Resistance
9. Chamie K, et al. (2008). Individuals who were exposed to Agent Orange had an increased incidence of prostate cancer, developed the disease at a younger age, and had a more aggressive variant than their unexposed counterparts. Agent Orange | Defoliants, Chemical Veterans United States Details Prostatic Neoplasms
10. Beard JD, et al. (2016). Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis (GENEVA) We evaluated associations between military-related factors and amyotrophic lateral sclerosis using data from a case-control study of US military veterans; among some of the positive associations (needing confirmation) were exposure to military herbicides, military nasopharyngeal radium, and Agent Orange. Agent Orange | Defoliants, Chemical | Radium Subjects with disease:Amyotrophic Lateral Sclerosis | Veterans United States Details Amyotrophic Lateral Sclerosis
11. Zablotska LB, et al. (2008). Health Effects of Arsenic Longitudinal Study (HEALS) Intakes of B-vitamins and antioxidants, at doses greater than the current recommended daily amounts for the country, may reduce the risk of arsenic-related skin lesions in Bangladesh. age | body mass index | sex | socioeconomic status Arsenic | Ascorbic Acid | Folic Acid | Pyridoxine | Riboflavin | Vitamin A | Vitamin E Study subjects Bangladesh Details Skin Ulcer
12. Orban JE, et al. (1994). National Human Adipose Tissue Survey (NHATS) The survey provides a baseline of average levels of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in the adipose tissue of humans in the US population. Benzofurans | Dioxins Study subjects United States adipose tissue 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzodioxin | 1,2,3,6,7,8-hexachlorodibenzodioxin | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,3,4,7,8-pentachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran | octachlorodibenzo-4-dioxin | Tetrachlorodibenzodioxin Details
13. LaKind JS, et al. (2009). Contrary to earlier research, we found that lipid-adjusted concentrations of polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, furans, and organochlorine pesticides in serum and milk do not consistently decrease during lactation and can increase for some women; thus, the concept of pumping and discarding early milk as means of reducing infant exposure is not supported. Benzofurans | Dioxins | Halogenated Diphenyl Ethers | Pesticides | Polychlorinated Biphenyls Mothers United States milk, human | serum 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,4,7,8-hexachlorodibenzofuran | 1,2,3,6,7,8-hexachlorodibenzodioxin | 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3,4,7,8-pentachlorodibenzofuran | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 3,4,5,3',4',5'-hexachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | DDT | Dichlorodiphenyl Dichloroethylene | hexabrominated diphenyl ether 153 | Hexachlorobenzene | Mirex | nonachlor | octachlorodibenzo-4-dioxin | octachlorodibenzofuran | oxychlordane | PCB 180 | pentabrominated diphenyl ether 100 Details
14. Humblet O, et al. (2011). This study provides suggestive evidence that average serum concentrations of dioxins, furans, and polychlorinated biphenyls are decreasing over time among residents in Chapaevsk, Russia. During this nine year period, larger decreases in serum total toxic equivalency and polychlorinated biphenyls were found in women with greater increases in body mass index. body mass index Benzofurans | Dioxins | Polychlorinated Biphenyls Study subjects Russian Federation serum 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,4,7,8-hexachlorodibenzodioxin | 1,2,3,4,7,8-hexachlorodibenzofuran | 1,2,3,6,7,8-hexachlorodibenzodioxin | 1,2,3,7,8-pentachlorodibenzofuran | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3,5,5',6-hexachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3,4,2',3',4'-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3,4,7,8-pentachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | 3,4,3',4'-tetrachlorobiphenyl | 3,4,5,3',4',5'-hexachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | octachlorodibenzofuran | PCB 180 | Polychlorinated Biphenyls | Tetrachlorodibenzodioxin Details
15. Keegan T, et al. (2007). Our results here show that experimental records at Porton Down offer a unique and valuable resource for reconstructing the chemical exposures used in this research programme. dibenz(b,f)(1,4)oxazepine | Mustard Gas | Sarin Veterans United Kingdom dibenz(b,f)(1,4)oxazepine | Mustard Gas | Sarin Details
16. Mínguez-Alarcón L, et al. (2016). Russian Children's Study Our prospective cohort study showed that higher peripubertal serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated dibenzo-p-dioxins toxic equivalents were associated with lower sperm concentration, total sperm count, and total motile sperm count measured 10 years later in healthy young men. Dibenzofurans, Polychlorinated | Dioxins | Furans | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Children | Study subjects Russian Federation serum Dibenzofurans, Polychlorinated | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Details Infertility, Male | spermatogenesis | sperm motility
17. Lin KC, et al. (2008). Our study showed dose-dependent neurocognitive deficits in certain aspects of attention, visual memory, and learning ability in women previously exposed to polychlorinated biphenyls and polychlorinated dibenzofurans, but not in exposed men. sex Dibenzofurans, Polychlorinated | Polychlorinated Biphenyls Study subjects Taiwan, Province of China Polychlorinated Biphenyls Details learning or memory
18. Aylward LL, et al. (2008). National Health and Nutrition Examination Survey (NHANES) | National Human Adipose Tissue Survey (NHATS) | University of Michigan Dioxin Exposure Study (UMDES) The objective of this study was to a) provide an assessment of the degree of change in lipid-adjusted toxic equivalent concentrations over the past three decades, and b) demonstrate the use of example human data sets in a margin of exposure framework for assessing noncancer risks of dioxins and related compounds. Dibenzofurans, Polychlorinated | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Children | Study subjects Italy|United States serum Dibenzofurans, Polychlorinated | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Details
19. Chang JW, et al. (2016). We find that serum dioxin/furan toxic equivalents and abdominal obesity affect the association with insulin resistance in the study population. Dioxins Subjects with disease:Obesity, Abdominal Taiwan, Province of China serum 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,7,8-pentachlorodibenzofuran | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,3,4,7,8-pentachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran | Tetrachlorodibenzodioxin Details Insulin Resistance
20. Mocarelli P, et al. (2011). In utero and lactational exposure of sons to relatively low dioxin doses can permanently reduce sperm quality. Dioxins Mothers | Study subjects Italy serum FSHB | INHBB | Tetrachlorodibenzodioxin Details spermatogenesis | sperm motility
21. Wattigney WA, et al. (2015). National Health and Nutrition Examination Survey (NHANES) We examined serum levels of persistent organic pollutants among four geographical U.S. regions (northeast, midwest, south, and west); differences in higher body burdens of exposure could be attributed to region-specific patterns of land use, industrial and agricultural chemical applications, and different levels of regulatory activity. Environmental Pollutants Study subjects United States serum 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,6,7,8-hexachlorodibenzodioxin | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | tribromodiphenyl ether 28 Details
22. Louis ED, et al. (2011). Blood harmane and lead concentrations separately correlated with total tremor scores. Participants with high blood concentrations of both toxicants had the highest tremor scores, suggesting an additive effect of these toxicants on tremor severity. harman | Lead Controls for disease:Essential Tremor | Subjects with disease:Essential Tremor United States blood harman | Lead Details Essential Tremor
23. Comba P, et al. (2003). The study shows a significant increase in risk of soft tissue sarcomas associated with residence within 2 km of an industrial waste incinerator; an aetiological role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can be hypothesised. Industrial Waste | Tetrachlorodibenzodioxin Study subjects Italy Details Sarcoma
24. Rodríguez-Dozal S, et al. (2012). Profile of pregnant women's exposure to persistent organic pollutants in Mexico Organic Chemicals Pregnant females Mexico blood | plasma 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3,4,2',3',4'-hexachlorobiphenyl | 2,3,4,4'5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | alpha-hexachlorocyclohexane | aroclor 1260 | beta-hexachlorocyclohexane | DDT | Dibenzofurans, Polychlorinated | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Lindane | Mirex | nonachlor | oxychlordane | PCB 180 | Polychlorinated Dibenzodioxins Details
25. Eskenazi B, et al. (2004). Seveso Women's Health Study (SWHS) In summary, female residents of the area near Seveso, Italy, at the time of the 1976 explosion were exposed to high levels of TCDD. Serum TCDD levels were related to a number of factors, particularly zone of residence and age. Tetrachlorodibenzodioxin Controls for disease:Chloracne | Subjects with disease:Chloracne | Study subjects Italy serum Tetrachlorodibenzodioxin Details
26. Warner M, et al. (2007). Seveso Women's Health Study (SWHS) We found no clear evidence that 1976 Tetrachlorodibenzodioxin exposure was associated with ovarian function 20 years later in women exposed to relatively high levels in Seveso, Italy. Tetrachlorodibenzodioxin Study subjects Italy serum Tetrachlorodibenzodioxin Details ovulation
27. Eskenazi B, et al. (2003). Seveso Women's Health Study (SWHS) We report the lack of an association between maternal serum levels of TCDD and adverse birth outcomes in the cohort of women exposed to dioxin in Seveso, Italy. However, associations of TCDD and lowered birth weight and SGA are somewhat stronger, albeit nonsignificant, for those pregnancies occurring in the first TCDD half-life (within 8 years) after the explosion. Tetrachlorodibenzodioxin Study subjects Italy serum Tetrachlorodibenzodioxin Details Abortion, Spontaneous | Prenatal Exposure Delayed Effects
28. Consonni D, et al. (2008). The Seveso accident in 1976 caused a large, populated area north of Milan, Italy, to be contaminated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this study, the authors followed up the exposed population for chronic effects; this paper reports the results of the mortality follow-up extension for 1997-2001. Tetrachlorodibenzodioxin Study subjects Italy Details Diabetes Mellitus | Leukemia | Lymphoma | Lymphoma, Non-Hodgkin | Multiple Myeloma | Neoplasms | Pulmonary Disease, Chronic Obstructive | Vascular Diseases
29. Pesatori AC, et al. (2009). The extension of the Seveso cancer incidence study confirmed an excess risk of lymphatic and hematopoietic tissue neoplasms in the most (2,3,7,8-tetrachlorodibenzo-p-dioxin) exposed zones. Tetrachlorodibenzodioxin Study subjects Italy Details Breast Neoplasms | Hematologic Neoplasms
30. Tuyet-Hanh TT, et al. (2010). This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. Tetrachlorodibenzodioxin Study subjects Vietnam food Tetrachlorodibenzodioxin Details
31. Warner M, et al. (2011). Seveso Women's Health Study (SWHS) Individual serum Tetrachlorodibenzodioxin is significantly positively related with all cancer incidence in the Seveso Women's Health Study cohort, more than 30 years later. This all-female study adds to the epidemiologic evidence that Tetrachlorodibenzodioxin is a multisite carcinogen. Tetrachlorodibenzodioxin Study subjects Italy serum Tetrachlorodibenzodioxin Details Neoplasms
32. Gupta A, et al. (2006). Tetrachlorodibenzodioxin exposure at general population levels is associated with a decreasing risk of benign prostatic hyperplasia with higher exposure levels; tetrachlorodibenzodioxin exposure is also negatively associated with serum testosterone levels. Tetrachlorodibenzodioxin Veterans United States serum Tetrachlorodibenzodioxin Details Prostatic Hyperplasia | testosterone biosynthetic process
1–32 of 32 results.