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Chemical Heterocyclic Compounds, 4 or More Rings

1–50 of 3,297 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1',2'-dihydrorotenone mitotic cell cycle arrest 1',2'-dihydrorotenone results in increased mitotic cell cycle arrest 1: Homo sapiens Plasma Cells | Cell Line, Tumor
2 genes: CDKN1A | TP53
1
2. 1',2'-dihydrorotenone cell proliferation 1',2'-dihydrorotenone results in decreased cell proliferation 1: Homo sapiens Plasma Cells | Cell Line, Tumor
3 genes: AKT1 | CDK4 | TP53
1
3. 1',2'-dihydrorotenone mitotic cell cycle arrest 1',2'-dihydrorotenone results in increased mitotic cell cycle arrest 1: Homo sapiens Plasma Cells
2 genes: CDKN1A | TP53
1
4. 1',2'-dihydrorotenone apoptotic process 1',2'-dihydrorotenone results in increased apoptotic process 1: Homo sapiens Plasma Cells
6 genes: AKT1 | E2F1 | MAPK1 | MAPK3 | RB1 | TP53
1
5. 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester positive regulation of cell proliferation Folic Acid Folic Acid deficiency inhibits the reaction [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased positive regulation of cell proliferation] 1: Homo sapiens Caco-2 Cells   1
6. 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester transport ABCG2 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport] 1: Bos taurus Kidney | Cell Line   1
7. 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester positive regulation of transport ABCG2 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein affects positive regulation of transport] 1: Capra hircus Madin Darby Canine Kidney Cells   1
8. 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester regulation of toxin transport ABCG2 [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which affects regulation of toxin transport 1: Canis lupus familiaris Madin Darby Canine Kidney Cells   1
9. 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester positive regulation of transport ABCG2 | Tetrachlorodibenzodioxin 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ABCG2 protein affects positive regulation of transport]] 1: Capra hircus Madin Darby Canine Kidney Cells   1
10. 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester positive regulation of transport ABCG2 | prochloraz 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [prochloraz promotes the reaction [ABCG2 protein affects positive regulation of transport]] 1: Capra hircus Madin Darby Canine Kidney Cells   1
11. 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester regulation of toxin transport ABCG2 [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which affects regulation of toxin transport 1: Homo sapiens Caco-2 Cells   1
12. 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride positive regulation of cell death Doxorubicin | rosiglitazone 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [[Doxorubicin co-treated with rosiglitazone] results in increased positive regulation of cell death] 1: Homo sapiens Breast | Cell Line, Tumor 1 gene: HMGB1 1
13. 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride apoptotic process Hemin 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Hemin results in increased apoptotic process] 1: Mus musculus Cell Line | Cerebral Cortex | Microvessels
5 genes: BAX | BCL2 | CASP3 | HMOX1 | PARP1
1
14. 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride positive regulation of cell death docetaxel | rosiglitazone 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [[docetaxel co-treated with rosiglitazone] results in increased positive regulation of cell death] 1: Homo sapiens Breast | Cell Line, Tumor 1 gene: HMGB1 1
15. 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride peptidyl-tyrosine modification Blood Glucose | Oxygen 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased peptidyl-tyrosine modification] 1: Rattus norvegicus Myocardium   1
16. 5,10,15,20-tetrakis(N-methyl-4'-pyridyl)porphyrinato-iron(III) peptidyl-tyrosine modification Mevinphos | Peroxynitrous Acid 5,10,15,20-tetrakis(N-methyl-4'-pyridyl)porphyrinato-iron(III) inhibits the reaction [Mevinphos promotes the reaction [Peroxynitrous Acid results in increased peptidyl-tyrosine modification]] 1: Rattus norvegicus Medulla Oblongata   1
17. 5,10,15,20-tetrakis(N-methyl-4'-pyridyl)porphyrinato-iron(III) neurological system process involved in regulation of systemic arterial blood pressure Mevinphos 5,10,15,20-tetrakis(N-methyl-4'-pyridyl)porphyrinato-iron(III) inhibits the reaction [Mevinphos affects neurological system process involved in regulation of systemic arterial blood pressure] 1: Rattus norvegicus Cardiovascular System   1
18. 6-codeinone positive regulation of apoptotic DNA fragmentation 6-codeinone results in increased positive regulation of apoptotic DNA fragmentation 1: Homo sapiens HL-60 Cells 1 gene: BAX 1
19. 6-codeinone cell death 6-codeinone results in increased cell death 1: Homo sapiens HL-60 Cells   1
20. 6-codeinone positive regulation of cell death 6-codeinone results in increased positive regulation of cell death 1: Homo sapiens Periodontal Ligament | Fibroblasts | Cells, Cultured   1
21. 6-codeinone positive regulation of cell death 6-codeinone results in increased positive regulation of cell death 1: Homo sapiens Dental Pulp | Cells, Cultured   1
22. 6-codeinone positive regulation of cell death 6-codeinone results in increased positive regulation of cell death 1: Homo sapiens Lung | Cell Line, Tumor   1
23. 6-codeinone positive regulation of release of cytochrome c from mitochondria 6-codeinone results in increased positive regulation of release of cytochrome c from mitochondria 1: Homo sapiens HL-60 Cells 1 gene: BAX 1
24. 6-codeinone positive regulation of cell death 6-codeinone results in increased positive regulation of cell death 1: Homo sapiens MCF-7 Cells   1
25. 6-codeinone cell death Acetylcysteine Acetylcysteine inhibits the reaction [6-codeinone results in increased cell death] 1: Homo sapiens HL-60 Cells   1
26. 6-codeinone positive regulation of cell death 6-codeinone results in increased positive regulation of cell death 1: Homo sapiens Gingiva | Fibroblasts | Cells, Cultured   1
27. AEOL 10150 positive regulation of oxidative stress-induced neuron death Isoflurophate AEOL 10150 inhibits the reaction [Isoflurophate results in increased positive regulation of oxidative stress-induced neuron death] 1: Rattus norvegicus Amygdala   1
28. AEOL 10150 positive regulation of oxidative stress-induced neuron death Isoflurophate AEOL 10150 inhibits the reaction [Isoflurophate results in increased positive regulation of oxidative stress-induced neuron death] 1: Rattus norvegicus Hippocampus   1
29. AEOL 10150 positive regulation of oxidative stress-induced neuron death Isoflurophate AEOL 10150 inhibits the reaction [Isoflurophate results in increased positive regulation of oxidative stress-induced neuron death] 1: Rattus norvegicus Piriform Cortex   1
30. AEOL 10150 cell death Paraquat | TXNRD2 AEOL 10150 inhibits the reaction [TXNRD2 mutant form promotes the reaction [Paraquat results in increased cell death]] 1: Rattus norvegicus Dopaminergic Neurons | Cell Line   1
31. Apomorphine locomotion involved in locomotory behavior Apomorphine results in increased locomotion involved in locomotory behavior 1: Mus musculus   1 gene: GLC-1 1
32. Apomorphine cell death 9-cis-retinal | cellular response to high light intensity Apomorphine inhibits the reaction [[9-cis-retinal results in increased cellular response to high light intensity] which results in increased cell death] 1: Mus musculus Photoreceptor Cells | Cell Line   1
33. Apomorphine regulation of heart rate Haloperidol Haloperidol inhibits the reaction [Apomorphine results in increased regulation of heart rate] 1: Canis lupus familiaris Cardiovascular System 1 gene: DRD2 1
34. Apomorphine vasodilation Indomethacin Indomethacin inhibits the reaction [Apomorphine results in increased vasodilation] 1: Rattus norvegicus Cerebral Cortex | Blood Vessels 1 gene: DRD1 1
35. Apomorphine regulation of blood pressure Apomorphine affects regulation of blood pressure 1: Rattus norvegicus Cardiovascular System 1 gene: TAC1 1
36. Apomorphine glycosylation Apomorphine results in increased glycosylation 2: Mus musculus | Rattus norvegicus Corpus Striatum   1
37. Apomorphine locomotion involved in locomotory behavior Quercetin | Rotenone Quercetin inhibits the reaction [[Apomorphine co-treated with Rotenone] affects locomotion involved in locomotory behavior] 1: Rattus norvegicus   1 gene: GLC-1 1
38. Apomorphine locomotion involved in locomotory behavior chrysin | Oxidopamine chrysin inhibits the reaction [Oxidopamine promotes the reaction [Apomorphine results in increased locomotion involved in locomotory behavior]] 1: Mus musculus   1 gene: GLC-1 1
39. Apomorphine regulation of heart rate Apomorphine affects regulation of heart rate 1: Rattus norvegicus Heart 1 gene: DRD2 1
40. Apomorphine regulation of blood pressure Haloperidol Haloperidol inhibits the reaction [Apomorphine results in decreased regulation of blood pressure] 1: Canis lupus familiaris Cardiovascular System 1 gene: TAC1 1
41. Apomorphine vasodilation Apomorphine results in increased vasodilation 1: Oryctolagus cuniculus Cardiovascular System 1 gene: DRD1 1
42. Apomorphine locomotion involved in locomotory behavior Oxidopamine Oxidopamine promotes the reaction [Apomorphine results in increased locomotion involved in locomotory behavior] 1: Mus musculus   1 gene: GLC-1 1
43. Apomorphine regulation of blood pressure Apomorphine results in decreased regulation of blood pressure 1: Canis lupus familiaris Cardiovascular System 1 gene: TAC1 2
44. Apomorphine apoptotic DNA fragmentation Oxidopamine Apomorphine inhibits the reaction [Oxidopamine results in increased apoptotic DNA fragmentation] 1: Homo sapiens Brain | Cell Line, Tumor   1
45. Apomorphine vasodilation Apomorphine results in increased vasodilation 1: Rattus norvegicus Cerebral Cortex | Blood Vessels 1 gene: DRD1 1
46. Apomorphine musculoskeletal movement phenylmethylpyrazolone | Rotenone phenylmethylpyrazolone inhibits the reaction [Rotenone promotes the reaction [Apomorphine results in increased musculoskeletal movement]] 1: Rattus norvegicus     1
47. Apomorphine adult locomotory behavior GLC-1 | GLC-2 | Ivermectin [[Apomorphine co-treated with Ivermectin] results in increased activity of [GLC-1 protein binds to GLC-2 protein]] which affects adult locomotory behavior 1: Caenorhabditis elegans Corpus Striatum 1 gene: GDNF 1
48. Apomorphine membrane lipid catabolic process Iron Apomorphine inhibits the reaction [Iron results in increased membrane lipid catabolic process] Microsomes   1
49. Apomorphine glycosylation Apomorphine results in increased glycosylation 2: Mus musculus | Rattus norvegicus Hippocampus   1
50. Apomorphine musculoskeletal movement Rotenone Rotenone promotes the reaction [Apomorphine results in increased musculoskeletal movement] 1: Rattus norvegicus     1
1–50 of 3,297 results.