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Chemical Hirudins

Name Hirudins
Equivalent Term Hirudin
Definition Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
Top Interacting
Genes
MeSH® ID D006629
External Links

Top ↑ Ancestors

ChemicalsAmino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated exposure references Peptides Has associated genes Has associated diseases Has associated exposure references Serpins Has associated genes Has associated diseases Antithrombin Proteins Has associated genes Has associated diseases Hirudins Has associated genes Has associated diseases

Top ↑ Descendants

Hirudins Has associated genes Has associated diseases
  5rolGLP-HV fusion peptide
  beta-naphthylsulfonyl-(d-Pip)-Ada-Abu-DFEEIPEEYLQ-OH-AcOH
  beta-naphthylsulfonyl-R-(d-Pip)-Ada-Abu-DYEPIPEEA-(Cha)-(d-Glu)-OH-AcOH
  bivalirudin Has associated genes Has associated diseases
  CX 397 Has associated diseases
  desirudin Has associated diseases
  hirudin (1-47)
  hirudin (1-49), leech
  hirudin (1-51)
  hirudin (42-63)
  hirudin (45-64)
  hirudin (53-64)
  hirudin (53-64), RGD-
  hirudin (54-64), N(alpha)-dinitrofluorobenzyl-
  hirudin (54-65)
  hirudin HV1 Has associated diseases
  hirudin HV2
  hirudin HV3
  hirudin -like fusion protein 8067, human
  hirudin, Lys(47)-
  hirudin PA
  hirudisin
  hirugen Has associated genes Has associated diseases
  hirulog 3-thrombin complex
  hirulog-B2
  hirulog-like peptide Has associated genes Has associated diseases
  hirutonin-2
  hirutonin-6
  lepidurin
  lepirudin Has associated genes Has associated diseases
  LU 52369
  LU 58463
  M23 urokinase
  N(alpha)-acetylhirudin(45-65)
  polyethyleneglycol-hirudin
  pseudohirudin
  recombinant hirudin, Ile(1)-Thr(2)-63-desulfato-
  RGD-hirudin
  SAK-RGD-K2-Hir
  SAK-RGD-K2-Hirul