1. |
1,2,3,4,6,7-hexachlorinated naphthalene
|
DNA damage response, detection of DNA damage
|
|
1,2,3,4,6,7-hexachlorinated naphthalene results in increased DNA damage response, detection of DNA damage |
1: Homo sapiens |
MCF-7 Cells |
|
1 |
2. |
1,2,3,5,6,7-hexachloronaphthalene
|
lipid oxidation
|
|
1,2,3,5,6,7-hexachloronaphthalene results in increased lipid oxidation |
1: Rattus norvegicus |
Liver |
|
1 |
3. |
1,2,3,5,6,7-hexachloronaphthalene
|
lipid oxidation
|
Malondialdehyde
|
[1,2,3,5,6,7-hexachloronaphthalene results in increased lipid oxidation] which results in increased abundance of Malondialdehyde |
1: Rattus norvegicus |
Liver |
|
1 |
4. |
1,2,3,5,6,7-hexachloronaphthalene
|
negative regulation of eating behavior
|
|
1,2,3,5,6,7-hexachloronaphthalene results in increased negative regulation of eating behavior |
1: Rattus norvegicus |
|
|
1 |
5. |
1,2,3,5,6,7-hexachloronaphthalene
|
embryonic skeletal system development
|
|
1,2,3,5,6,7-hexachloronaphthalene results in decreased embryonic skeletal system development |
1: Rattus norvegicus |
Fetus | Bone and Bones |
|
1 |
6. |
1,2,3,5,6,7-hexachloronaphthalene
|
ossification involved in bone maturation
|
|
1,2,3,5,6,7-hexachloronaphthalene results in decreased ossification involved in bone maturation |
1: Rattus norvegicus |
Fetus | Bone and Bones |
|
1 |
7. |
1,2,3,5,6,7-hexachloronaphthalene
|
placenta development
|
|
1,2,3,5,6,7-hexachloronaphthalene results in decreased placenta development |
1: Rattus norvegicus |
Uterus |
|
1 |
8. |
1,2,5,6-tetrabromocyclooctane
|
regulation of endocrine process
|
|
1,2,5,6-tetrabromocyclooctane affects regulation of endocrine process |
1: Homo sapiens |
Adrenal Glands | Cell Line, Tumor |
|
1 |
9. |
1,2,5,6-tetrabromocyclooctane
|
regulation of testosterone biosynthetic process
|
|
1,2,5,6-tetrabromocyclooctane results in increased regulation of testosterone biosynthetic process |
1: Homo sapiens |
Adrenal Glands | Cell Line, Tumor |
|
1 |
10. |
1,2,5,6-tetrabromocyclooctane
|
estrogen biosynthetic process
|
|
1,2,5,6-tetrabromocyclooctane results in increased estrogen biosynthetic process |
1: Homo sapiens |
Adrenal Glands | Cell Line, Tumor |
1 gene: STAR
|
1 |
11. |
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea
|
DNA repair
|
|
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased DNA repair |
1: Homo sapiens |
MCF-7 Cells |
9 genes: ATM | CHEK1 | CHEK2 | ERCC3 | ERCC5 | FANCD2 | MGMT | PARP1 | RAD51
|
1 |
12. |
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea
|
mitotic cell cycle arrest
|
|
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased mitotic cell cycle arrest |
1: Homo sapiens |
MCF-7 Cells |
|
1 |
13. |
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea
|
apoptotic process
|
|
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased apoptotic process |
1: Homo sapiens |
MCF-7 Cells |
8 genes: ATM | CASP7 | CASP8 | CASP9 | CHEK1 | CHEK2 | ERCC3 | PARP1
|
1 |
14. |
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea
|
cell proliferation
|
|
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in decreased cell proliferation |
1: Homo sapiens |
MCF-7 Cells |
|
1 |
15. |
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea
|
cell proliferation
|
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
|
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in decreased cell proliferation] |
1: Homo sapiens |
MCF-7 Cells |
|
1 |
16. |
1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea
|
cell proliferation
|
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine
|
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in decreased cell proliferation] |
1: Homo sapiens |
MCF-7 Cells |
|
1 |
17. |
1-bromopropane
|
positive regulation of blood pressure
|
|
1-bromopropane results in increased positive regulation of blood pressure |
1: Rattus norvegicus |
Cardiovascular System |
|
1 |
18. |
1-bromopropane
|
glutathione biosynthetic process
|
|
1-bromopropane results in decreased glutathione biosynthetic process |
1: Rattus norvegicus |
Aorta |
2 genes: GCLC | GCLM
|
1 |
19. |
1-bromopropane
|
lipid catabolic process
|
|
1-bromopropane results in decreased lipid catabolic process |
1: Rattus norvegicus |
Aorta |
|
1 |
20. |
1-bromopropane
|
protein modification process
|
|
1-bromopropane results in increased protein modification process |
1: Rattus norvegicus |
Aorta |
|
1 |
21. |
1-bromopropane
|
glutathione biosynthetic process
|
|
1-bromopropane results in decreased glutathione biosynthetic process |
1: Mus musculus |
Liver |
2 genes: GCLC | GCLM
|
1 |
22. |
1-bromopropane
|
glutathione biosynthetic process
|
|
1-bromopropane results in decreased glutathione biosynthetic process |
1: Mus musculus |
Spleen |
2 genes: GCLC | GCLM
|
1 |
23. |
1-bromopropane
|
glutathione biosynthetic process
|
Glutathione
|
[1-bromopropane results in decreased glutathione biosynthetic process] which results in increased chemical synthesis of Glutathione analog |
1: Mus musculus |
Liver |
2 genes: GCLC | GCLM
|
1 |
24. |
1-chloro-2,4-dinitrobenzene-glutathione conjugate
|
glutathione transferase activity
|
beta-Naphthoflavone
|
[beta-Naphthoflavone results in increased glutathione transferase activity] which results in increased abundance of 1-chloro-2,4-dinitrobenzene-glutathione conjugate |
1: Rattus norvegicus |
Liver |
6 genes: GSTA3 | GSTM1 | GSTM2 | GSTM3 | GSTM5 | GSTP1
|
1 |
25. |
1-chloro-2,4-dinitrobenzene-glutathione conjugate
|
glutathione transferase activity
|
indole-3-carbinol
|
[indole-3-carbinol results in increased glutathione transferase activity] which results in increased abundance of 1-chloro-2,4-dinitrobenzene-glutathione conjugate |
1: Rattus norvegicus |
Liver |
6 genes: GSTA3 | GSTM1 | GSTM2 | GSTM3 | GSTM5 | GSTP1
|
1 |
26. |
1-chloro-2,4-dinitrobenzene-glutathione conjugate
|
glutathione transferase activity
|
oltipraz
|
[oltipraz results in increased glutathione transferase activity] which results in increased abundance of 1-chloro-2,4-dinitrobenzene-glutathione conjugate |
1: Rattus norvegicus |
Liver |
6 genes: GSTA3 | GSTM1 | GSTM2 | GSTM3 | GSTM5 | GSTP1
|
1 |
27. |
1-chloro-2,4-dinitrobenzene-glutathione conjugate
|
glutathione transferase activity
|
Phenobarbital
|
[Phenobarbital results in increased glutathione transferase activity] which results in increased abundance of 1-chloro-2,4-dinitrobenzene-glutathione conjugate |
1: Rattus norvegicus |
Liver |
6 genes: GSTA3 | GSTM1 | GSTM2 | GSTM3 | GSTM5 | GSTP1
|
1 |
28. |
1-chloro-2,4-dinitrobenzene-glutathione conjugate
|
glutathione transferase activity
|
stilbene oxide
|
[stilbene oxide results in increased glutathione transferase activity] which results in increased abundance of 1-chloro-2,4-dinitrobenzene-glutathione conjugate |
1: Rattus norvegicus |
Liver |
6 genes: GSTA3 | GSTM1 | GSTM2 | GSTM3 | GSTM5 | GSTP1
|
1 |
29. |
1-chloro-2,4-dinitrobenzene-glutathione conjugate
|
glutathione transferase activity
|
Butylated Hydroxyanisole
|
[Butylated Hydroxyanisole results in increased glutathione transferase activity] which results in increased abundance of 1-chloro-2,4-dinitrobenzene-glutathione conjugate |
1: Rattus norvegicus |
Liver |
6 genes: GSTA3 | GSTM1 | GSTM2 | GSTM3 | GSTM5 | GSTP1
|
1 |
30. |
1-chloro-2,4-dinitrobenzene-glutathione conjugate
|
glutathione transferase activity
|
benzyl isothiocyanate
|
[benzyl isothiocyanate results in increased glutathione transferase activity] which results in increased abundance of 1-chloro-2,4-dinitrobenzene-glutathione conjugate |
1: Rattus norvegicus |
Liver |
6 genes: GSTA3 | GSTM1 | GSTM2 | GSTM3 | GSTM5 | GSTP1
|
1 |
31. |
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
|
positive regulation of cell death
|
|
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased positive regulation of cell death |
1: Mus musculus |
Hippocampus | Neurons | Cells, Cultured |
1 gene: PTGS2
|
1 |
32. |
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
|
positive regulation of cell death
|
|
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased positive regulation of cell death |
1: Mus musculus |
Neocortex | Neurons | Cells, Cultured |
1 gene: PTGS2
|
1 |
33. |
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
|
positive regulation of cell death
|
|
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased positive regulation of cell death |
1: Mus musculus |
Cerebellum | Neurons | Cells, Cultured |
1 gene: PTGS2
|
1 |
34. |
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
|
DNA hypomethylation
|
|
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased DNA hypomethylation |
1: Mus musculus |
Hippocampus | Neurons | Cells, Cultured |
|
1 |
35. |
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
|
positive regulation of cell death
|
RXRA
|
RXRA mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased positive regulation of cell death] |
1: Mus musculus |
Hippocampus | Neurons | Cells, Cultured |
1 gene: PTGS2
|
1 |
36. |
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
|
positive regulation of cell death
|
RXRB
|
RXRB mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased positive regulation of cell death] |
1: Mus musculus |
Hippocampus | Neurons | Cells, Cultured |
1 gene: PTGS2
|
1 |
37. |
2,2',2''-trichlorotriethylamine
|
DNA alkylation
|
|
2,2',2''-trichlorotriethylamine results in increased DNA alkylation |
|
|
|
1 |
38. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
interleukin-8 production
|
|
2,2',3,3',4,4',5-heptachlorobiphenyl affects interleukin-8 production |
1: Homo sapiens |
|
|
1 |
39. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
production of molecular mediator of immune response
|
|
2,2',3,3',4,4',5-heptachlorobiphenyl results in increased production of molecular mediator of immune response |
1: Homo sapiens |
Blood |
|
1 |
40. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
cognition
|
|
2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased cognition |
1: Homo sapiens |
Brain |
|
1 |
41. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
triglyceride metabolic process
|
|
2,2',3,3',4,4',5-heptachlorobiphenyl affects triglyceride metabolic process |
1: Homo sapiens |
Serum |
|
1 |
42. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
neural crest cell migration
|
|
2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased neural crest cell migration |
1: Homo sapiens |
Neural Stem Cells | Cell Line |
|
1 |
43. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
negative regulation of androgen receptor activity
|
|
2,2',3,3',4,4',5-heptachlorobiphenyl results in increased negative regulation of androgen receptor activity |
1: Homo sapiens |
Osteoblasts | Cell Line, Tumor |
|
1 |
44. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
negative regulation of androgen receptor activity
|
Dihydrotestosterone
|
[2,2',3,3',4,4',5-heptachlorobiphenyl results in increased negative regulation of androgen receptor activity] which results in decreased susceptibility to Dihydrotestosterone |
1: Homo sapiens |
Osteoblasts | Cell Line, Tumor |
|
1 |
45. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
progesterone receptor signaling pathway
|
|
2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased progesterone receptor signaling pathway |
1: Homo sapiens |
Osteoblasts | Cell Line, Tumor |
1 gene: PGR
|
1 |
46. |
2,2',3,3',4,4',5-heptachlorobiphenyl
|
progesterone receptor signaling pathway
|
16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione
|
[2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased progesterone receptor signaling pathway] which results in decreased susceptibility to 16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione |
1: Homo sapiens |
Osteoblasts | Cell Line, Tumor |
1 gene: PGR
|
1 |
47. |
2,2',3',4,4',5-hexachlorobiphenyl
|
production of molecular mediator of immune response
|
|
2,2',3',4,4',5-hexachlorobiphenyl results in increased production of molecular mediator of immune response |
1: Homo sapiens |
Blood |
|
1 |
48. |
2,2',3',4,4',5-hexachlorobiphenyl
|
flagellated sperm motility
|
|
2,2',3',4,4',5-hexachlorobiphenyl results in decreased flagellated sperm motility |
1: Homo sapiens |
Spermatozoa |
8 genes: ATP2B4 | CATSPERD | CHRNA7 | GAPDHS | MET | NEURL1A | TEKT2 | TTLL5
|
1 |
49. |
2,2',3',4,4',5-hexachlorobiphenyl
|
hormone metabolic process
|
|
2,2',3',4,4',5-hexachlorobiphenyl affects hormone metabolic process |
1: Homo sapiens |
Blood |
|
1 |
50. |
2,2',3',4,4',5-hexachlorobiphenyl
|
cognition
|
|
2,2',3',4,4',5-hexachlorobiphenyl results in decreased cognition |
1: Homo sapiens |
Brain |
10 genes: APP | CHRM1 | CHRNA7 | CTNS | FAM107A | GNAS | GRM5 | HRH3 | HTR4 | TNF
|
1 |