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Chemical Hypoglycins

Name Hypoglycins
Definition Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D007005
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Top ↑ Ancestors

1. ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Hydrocarbons Has associated genes Has associated diseases Has associated exposure references Hydrocarbons, Cyclic Has associated genes Has associated diseases Has associated exposure references Hydrocarbons, Alicyclic Has associated genes Has associated diseases Has associated exposure references Cycloparaffins Has associated genes Has associated diseases Has associated exposure references Cyclopropanes Has associated genes Has associated diseases Hypoglycins
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Hypoglycins

Top ↑ Descendants

Hypoglycins
  hypoglycin
  ketohypoglycin