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Chemical Imidazoles

These are exposure studies associated with the chemical and all of its children.

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1–36 of 36 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Hoppin JA, et al. (2017). Agricultural Health Study (AHS) We evaluated the association of currently used pesticides with allergic and non-allergic wheeze among male farmers, and our results implicate several pesticides that are commonly used in agricultural and residential settings with adverse respiratory effects. 2,4-Dichlorophenoxyacetic Acid | acetochlor | Atrazine | bentazone | Carbaryl | Chlorpyrifos | clomazone | clopyralid | cyfluthrin | Dicamba | Dimethoate | Disulfoton | fenoxaprop ethyl | fluazifop-butyl | glyphosate | Herbicides | imazaquin | Insecticides | Malathion | mesotrione | metolachlor | N-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide | nicosulfuron | Permethrin | Petroleum | Picloram | Pyrethrins | Rodenticides | Simazine | triclopyr | Trifluralin | Warfarin Workers United States Details Respiratory Sounds | Rhinitis, Allergic
2. Le NT, et al. (2016). Health Professionals Follow-up Study (HPFS) | Nurses' Health Study (NHS) Results from these two large prospective cohort studies do not support the hypothesis that higher intake of heterocyclic amine intake per se substantially increases risk of colorectal cancer. However, we observed positive association between 2-amino-1-methyl-6-phenylimidazo pyridine from red meat, but not from white meat, and proximal colon cancers. 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Workers United States Details Colorectal Neoplasms
3. Smarr MM, et al. (2017). Longitudinal Investigation of Fertility and the Environment Study (LIFE) Higher quartiles of preconception urinary concentrations of methyl paraben and ethyl paraben among female partners were associated with reduced couple fecundity in partner-specific and couple-based exposure models. sex 4-hydroxybenzoic acid | Anti-Infective Agents | benzylparaben | butylparaben | ethyl-p-hydroxybenzoate | heptylparaben | methylparaben | Parabens | propylparaben | protocatechuic acid | triclocarban | Triclosan Study subjects United States urine 4-hydroxybenzoic acid | benzylparaben | butylparaben | Creatinine | ethyl-p-hydroxybenzoate | heptylparaben | methylparaben | propylparaben | protocatechuic acid | triclocarban | Triclosan Details Infertility, Female | reproductive process
4. Ueyama J, et al. (2014). In this study, we developed and validated a rapid and sensitive method for quantifying urinary neonicotinoid (NEO) concentrations using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). acetamiprid | dinotefuran | ((E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine) | imidacloprid | nitenpyram | thiacloprid | thiamethoxam Study subjects Japan urine acetamiprid | dinotefuran | ((E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine) | imidacloprid | nitenpyram | thiacloprid | thiamethoxam Details
5. Currier JM, et al. (2014). Our results provide additional support that trivalent arsenic species may be responsible for associations between diabetes and chronic inorganic arsenic exposure. Arsenic Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus Mexico cell, urothelial, exfoliated | urine | water, drinking arsenic acid | Arsenicals | Arsenic | arsenite | Cacodylic Acid | Creatinine | dimethylarsinous acid | methylarsonite | monomethylarsonic acid Details Diabetes Mellitus
6. Howe CG, et al. (2016). Folic Acid and Creatine Trial (FACT) The data reported herein add to a growing body of evidence that arsenic induces epigenetic dysregulation on a global level and, moreover, that this often occurs in a sex-specific manner. sex Arsenic Study subjects Bangladesh blood | urine Arsenic | Creatinine Details histone H3-K36 dimethylation
7. Mendez MA, et al. (2016). The results of this study fill a gap in current knowledge by suggesting potential cardiometabolic risks associated with chronic exposure to arsenic at levels < 100 micrograms per liter in drinking water. Arsenic Study subjects Mexico urine | water Arsenic | Creatinine Details Diabetes Mellitus | regulation of cholesterol metabolic process | regulation of triglyceride metabolic process
8. de Burbure C, et al. (2006). Renal and Neurologic Effects of Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and Multiple Interactions at Environmental Exposure Levels Arsenic | Cadmium | Creatinine | Lead | Mercury Children Czech Republic|France|
Poland
blood | serum | urine Arsenic | Cadmium | Creatinine | Lead | Mercury Details gene expression | renal filtration | renal system process
9. Karmaus W, et al. (2008). The findings of this 2-year follow-up study indicate that metals and metalloids do not play a role in the etiology of Balkan Endemic Nephropathy. Against the assumption in the literature, selenium was not protective but a risk factor. Arsenic | Cadmium | Creatinine | Lead | Selenium Study subjects Bulgaria blood | serum | urine Arsenic | Cadmium | Creatinine | Lead | Selenium Details Balkan Nephropathy | creatinine homeostasis | gene expression
10. Rager JE, et al. (2015). We found arsenic- and cancer-associated genes are enriched for the binding sites of common transcription factors known to play roles in carcinogenesis, demonstrating a novel potential mechanistic link between inorganic arsenic exposure and bladder cancer. Arsenic | Creatinine Study subjects Mexico cell, urothelial, exfoliated | urine | water, drinking arsenic acid | Arsenicals | Arsenic | arsenite | Cacodylic Acid | Creatinine | dimethylarsinous acid | methylarsonite | monomethylarsonic acid Details
11. Hall M, et al. (2007). In summary, we have demonstrated strong relationships between maternal and cord total blood Arsenic and blood Arsenic metabolite concentrations, which indicate that newborn children in Matlab, and likely other regions of Bangladesh, are exposed to hazardous concentrations of Arsenic metabolites during the prenatal period. Arsenic | Creatinine Infants or newborns | Pregnant females Bangladesh blood | blood, cord | urine | water Arsenic | Creatinine Details
12. Breton CV, et al. (2007). These results suggest the APE1 variant genotype decreases repair of 8-hydroxy-2'-deoxyguanosine and that arsenic exposure is associated with oxidative stress in women who lack a functional GSTM1 detoxification enzyme. genetics Arsenic | Creatinine Subjects with gene influence:APEX1 | Subjects with gene influence:GSTM1 | Study subjects Bangladesh nail | urine | water Arsenic | Creatinine Details response to oxidative stress
13. Parvez F, et al. (2008). The findings suggest that serum CC16 may be a useful biomarker of epithelial lung damage in individuals with arsenical skin lesions. Arsenic | Creatinine Controls for disease:Skin Ulcer | Subjects with disease:Skin Ulcer | Study subjects Bangladesh urine | water Arsenic | Creatinine | SCGB1A1 Details gene expression | methylation
14. Kile ML, et al. (2012). Exposure to higher levels of arsenic was positively associated with DNA methylation in LINE-1 repeated elements, and to a lesser degree at CpG sites within the promoter region of the tumor suppressor gene p16 (CDKN2A); associations were observed in both maternal and fetal leukocytes. Arsenic | Creatinine Pregnant females Bangladesh leukocyte | urine | water, drinking Arsenicals | Arsenic | CDKN2A | Creatinine Details regulation of DNA methylation
15. Gamble MV, et al. (2005). Nutritional Influences on Arsenic Toxicity Study (NIAT) Our objectives of this cross-sectional study were to characterize the relationships among folate, cobalamin, homocysteine, and arsenic metabolism in Bangladeshi adults. Arsenic | Creatinine | Folic Acid Study subjects Bangladesh urine | water Arsenic Details methylation | response to arsenic-containing substance
16. Hall MN, et al. (2009). In summary, among this group of Bangladeshi adults with a high prevalence of cobalamin deficiency, cobalamin appeared to facilitate the methylation of inorganic arsenic to monomethylarsonic acid, particularly among women and among folate sufficient individuals. Arsenic | Creatinine | Folic Acid | Homocysteine | Vitamin B 12 Study subjects Bangladesh plasma | urine | water Arsenic | Creatinine | Folic Acid | Homocysteine | Vitamin B 12 Details
17. George CM, et al. (2013). Health Effects of Arsenic Longitudinal Study (HEALS) Our results suggest that selenium is inversely associated with biomarkers of arsenic burden in both adults and children. Arsenic | Creatinine | Folic Acid | Selenium | Vitamin B 12 Children | Study subjects Bangladesh blood | urine | water Arsenic | Creatinine | Folic Acid | Selenium | Vitamin B 12 Details
18. Wasserman GA, et al. (2004). Water arsenic (As) was associated with reduced intellectual function, in a dose-response manner, such that children with water As levels > 50 microg/L achieved significantly lower Performance and Full-Scale scores than did children with water As levels < 5.5 microg/L. diet Arsenic | Creatinine | Lead | Manganese Children Bangladesh blood | urine | water Arsenic | Creatinine | Lead | Manganese Details cognition
19. Wasserman GA, et al. (2006). This study indicates that exposure to Mn in drinking water is associated with neurotoxic effects in children. Arsenic | Creatinine | Lead | Manganese | Mercury Children Bangladesh blood | urine | water Arsenic | Creatinine | Lead | Manganese | Mercury Details cognition
20. Hall MN, et al. (2009). Health Effects of Arsenic Longitudinal Study (HEALS) These findings suggest that, similar to adults, folate and cysteine facilitate arsenic methylation in children. However, the inverse correlation between total homocysteine and %monomethylarsonic, and positive correlation with %dimethylarsinic acids, are both opposite to our previous findings in adults. age Arsenic | Cysteine | Folic Acid Children Bangladesh plasma | urine | water Arsenic | Creatinine | Cysteine | Folic Acid | Homocysteine | Vitamin B 12 Details cellular response to chemical stimulus
21. Parvez F, et al. (2011). Our research demonstrates an adverse association of arsenic exposure and a protective association of selenium on motor function in children. Arsenic | Lead | Manganese | Selenium Children Bangladesh blood | nail | urine | water, well Arsenic | Creatinine | Lead | Manganese | Selenium Details
22. Rudel RA, et al. (2011). In this study, geometric mean (GM) urinary bisphenol A (BPA) concentrations fell by 66% and GM bis(2-ethylhexyl) phthalate (DEHP) metabolite concentrations fell by 53-56% when participants began a 'fresh foods' diet, suggesting that most BPA and DEHP intake came from food packaging or meals outside the home. bisphenol A | Diethylhexyl Phthalate | Phthalic Acids Children | Study subjects United States urine bisphenol A | Creatinine | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | monomethyl phthalate Details
23. Scinicariello F, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We examined the association of bisphenol A (BPA), benzophenone-3 (BP-3), triclosan (TCS), and parabens with serum total testosterone (TT) levels in child and adolescent participants (ages 6-19 years) in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. sex bisphenol A | oxybenzone | Parabens | Triclosan Children United States serum | urine bisphenol A | Cotinine | Creatinine | oxybenzone | Parabens | Testosterone | Triclosan Details testosterone biosynthetic process
24. Bornehag CG, et al. (2015). National Health and Nutrition Examination Survey (NHANES) | Study for Future Families (SFF) | Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) Study We find that diisononyl phthalate is associated with a shorter anogenital distance in boys at the age of 21 months, which is of concern because AGD has been related to male genital birth defects and impaired reproductive function in adult males. butylbenzyl phthalate | Dibutyl Phthalate | Diethylhexyl Phthalate | diethyl phthalate | diisononyl phthalate | Phthalic Acids Infants or newborns | Pregnant females | Study subjects Sweden|United States urine 2-ethyl-5-carboxypentyl phthalate | Creatinine | Diethylhexyl Phthalate | diisononyl phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate Details Prenatal Exposure Delayed Effects | anatomical structure development
25. Wallin M, et al. (2014). The aim of this study was to explore the relation between kidney function and low or moderate cadmium levels, measured directly in kidney biopsies. Cadmium Study subjects Sweden blood | kidney | urine ALB | AMBP | B2M | Cadmium | Creatinine Details renal system process
26. Nawrot TS, et al. (2008). Cadmium in Belgium Study (CadmiBel) The key finding of our study was that in exclusively environmentally exposed subjects, the internal dose of cadmium predicted total and noncardiovascular mortality. Cadmium Controls for disease:Death | Subjects with disease:Death | Study subjects Belgium blood | urine Cadmium | Creatinine Details Death
27. Ellis JK, et al. (2012). This study shows evidence that metabolic profiling in an uncontrolled human population is capable of identifying intermediate biomarkers of response to cadmium at true environmental concentrations, paving the way for exposome research. Cadmium Study subjects United Kingdom urine 8-oxo-7-hydrodeoxyguanosine | beta-hydroxyisovaleric acid | Citric Acid | Creatine | Creatinine Details cellular response to oxidative stress
28. Den Hond E, et al. (2015). COnsortium to Perform Human biomonitoring on a European Scale (COPHES) | DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale (DEMOCOPHES) | National Health and Nutrition Examination Survey (NHANES) We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe for measuring levels of mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of children and mothers. Cadmium | Cotinine | Creatinine | Diethylhexyl Phthalate | Mercury | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate Children | Mothers | Study subjects Belgium|Cyprus|
Czech Republic|Denmark|
Germany|Hungary|
Ireland|Luxembourg|
Poland|Portugal|
Romania|Slovakia|
Slovenia|Spain|
Sweden|Switzerland|
United Kingdom|United States
hair | urine Cadmium | Cotinine | Creatinine | Diethylhexyl Phthalate | Mercury | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate Details
29. Akesson A, et al. (2005). Women's Health in the Lund Area Study (WHILA) This population-based study of upper-middle-age women, representative of the general population of southern Sweden, showed clear associations between cadmium and the renal tubular-effect markers protein HC and NAG, even at the low levels of cadmium found in never-smokers. Cadmium | Creatinine | Lead Subjects with disease:Diabetes Mellitus | Study subjects Sweden blood | serum | urine AMBP | Cadmium | Calcium | Creatinine | CST3 | Lead Details glomerular filtration | renal system process
30. van Wendel de Joode B, et al. (2016). Our findings indicate that children living near banana and plantain plantations are exposed to pesticides that may affect their neurodevelopment, which for certain domains may differ between boys and girls. sex Chlorpyrifos | mancozeb | Pyrethrins Children Costa Rica urine 3,5,6-trichloro-2-pyridinol | 3-phenoxybenzoic acid | Ethylenethiourea Details Attention Deficit Disorder with Hyperactivity | behavior | cognition | learned vocalization behavior or vocal learning | memory | visual perception
31. Mervish N, et al. (2012). National Health and Nutrition Examination Survey (NHANES) The results of the present study demonstrate fair temporal reliability in the spot urine concentrations of the three sodium iodide symporter inhibitors and iodide. Creatinine | Iodides | Nitrates | perchlorate | thiocyanate Children United States urine Creatinine | Iodides | Nitrates | perchlorate | thiocyanate Details
32. Valentín-Blasini L, et al. (2011). Study of Estrogen Activity and Development (SEAD) We measured perchlorate and related anions (nitrate, thiocyanate, and iodide) in 206 urine samples from 92 infants ages 1-377 days and calculated perchlorate intake dose for this sample of infants. Estimated exposure dose differed by feeding method. diet Creatinine | Iodides | Nitrates | perchlorate | thiocyanate Infants or newborns United States urine Creatinine | Iodides | Nitrates | perchlorate | thiocyanate Details
33. Philippat C, et al. (2013). Study of Advanced Reproductive Age and Environmental Health (SARAEH) Amniotic fluid detection frequencies for most phenols were low; the reproducibility of urine measures was poor for bisphenol A, but good for the other phenols; collecting multiple urine samples during pregnancy is an option to reduce exposure measurement error. Creatinine | Phenols Pregnant females United States amniotic fluid | urine 2,4-dichlorophenol | 2,5-dichlorophenol | bisphenol A | butylparaben | Creatinine | ethyl-p-hydroxybenzoate | methylparaben | oxybenzone | propylparaben | Triclosan Details
34. Gunier RB, et al. (2011). Agricultural pesticide use near residences was a significant determinant of concentrations of pesticides in carpet dust for five of seven pesticides evaluated. Fungicides, Industrial | Herbicides | Insecticides United States dust Carbaryl | Chlorpyrifos | Diazinon | dimethyl 2,3,5,6-tetrachloroterephthalate | iprodione | Phosmet | Simazine Details
35. Chevrier C, et al. (2011). PELAGIE This study is the first to assess associations of birth outcomes with multiple urinary biomarkers of exposure to triazine and chloroacetanilide herbicides. Evidence of associations with adverse birth outcomes raises particular concerns for countries where atrazine is still in use. Herbicides Fetuses | Pregnant females France urine 2,6-diethylaniline | acetochlor | alachlor | ammeline | Atrazine | atrazine mercapturate | Creatinine | desethylatrazine | metolachlor | Simazine Details Congenital Abnormalities | Fetal Growth Retardation | Pregnancy Complications | head development
36. Castorina R, et al. (2010). Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) | National Health and Nutrition Examination Survey (NHANES) Our findings indicate that pregnant women in the Salinas Valley are chronically exposed to several current-use organophosphorus and organochlorine pesticides and chlorinated phenols, with additional intermittent exposures to other pesticides. Findings suggest that the CHAMACOS cohort has an additional burden of precursor pesticide exposure compared with the national sample, possibly from living and/or working in an agricultural area. Pesticides Pregnant females United States urine 1-naphthol | 2,4,5-trichlorophenol | 2,4,6-trichlorophenol | 2,4-dichlorophenol | 2,4-Dichlorophenoxyacetic Acid | 2,5-dichlorophenol | 2-naphthol | 2-phenylphenol | 3,5,6-trichloro-2-pyridinol | 3-phenoxybenzoic acid | 4-nitrophenol | acephate | DEET | Dimethoate | Ethylenethiourea | Pentachlorophenol Details
1–36 of 36 results.