1. |
10-(2-(5H-(1,2,4)triazino(5,6-b)indol-3-ylthio)butanoyl)-10H-phenothiazine
|
cell proliferation
|
Resveratrol
| Sodium Fluoride
|
10-(2-(5H-(1,2,4)triazino(5,6-b)indol-3-ylthio)butanoyl)-10H-phenothiazine inhibits the reaction [Resveratrol inhibits the reaction [Sodium Fluoride results in decreased cell proliferation]] |
1: Mus musculus |
Ameloblasts | Cell Line |
|
1 |
2. |
10-decarbamoylmitomycin C
|
apoptotic process
|
|
10-decarbamoylmitomycin C results in increased apoptotic process |
1: Homo sapiens |
Cell Line, Tumor |
4 genes: CASP3 | CASP9 | CHEK1 | TP53
|
1 |
3. |
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane
|
positive regulation of neuron apoptotic process
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of neuron apoptotic process] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
|
1 |
4. |
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane
|
locomotory behavior
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased locomotory behavior] |
1: Mus musculus |
|
2 genes: SLC6A3 | TH
|
1 |
5. |
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of I-kappaB kinase/NF-kappaB signaling] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
3 genes: CASP1 | IL1A | TLR4
|
1 |
6. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
positive regulation of neuron apoptotic process
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of neuron apoptotic process] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
3 genes: ATF4 | CASP3 | DDIT3
|
1 |
7. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of I-kappaB kinase/NF-kappaB signaling] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
1 gene: CASP8
|
1 |
8. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
9. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
NR4A1
|
NR4A1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation] |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
10. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
apoptotic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased apoptotic process |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
12 genes: BCL2 | BID | BIRC5 | CASP3 | CASP7 | CASP8 | DDIT3 | EP300 | NR4A1 | PARP1 | RPS6KB1 | XBP1
|
1 |
11. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
reactive oxygen species biosynthetic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
|
1 |
12. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell adhesion
|
FN1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [FN1 protein results in increased cell adhesion] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
2 genes: ITGB1 | ITGB3
|
1 |
13. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell adhesion
|
FN1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [FN1 protein results in increased cell adhesion] |
1: Homo sapiens |
MCF-7 Cells |
2 genes: ITGB1 | ITGB3
|
1 |
14. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
15. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
NR4A1
|
NR4A1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
16. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
ITGB1
|
ITGB1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
17. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
TGFB1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [TGFB1 protein results in increased cell migration] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
18. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
DNA damage response, detection of DNA damage
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased DNA damage response, detection of DNA damage |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
1 gene: PARP1
|
1 |
19. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
calcium ion homeostasis
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane affects calcium ion homeostasis |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
|
1 |
20. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
reactive oxygen species biosynthetic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
|
1 |
21. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
reactive oxygen species biosynthetic process
|
Glutathione
|
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
|
1 |
22. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
NR4A1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane affects the reaction [NR4A1 protein affects cell proliferation] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
23. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
24. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
apoptotic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased apoptotic process |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
12 genes: BCL2 | BID | BIRC5 | CASP3 | CASP7 | CASP8 | DDIT3 | EP300 | NR4A1 | PARP1 | RPS6KB1 | XBP1
|
1 |
25. |
1,1-bis(3'-indolyl)-1-(p-anisyl)methane
|
positive regulation of neuron apoptotic process
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of neuron apoptotic process] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
|
1 |
26. |
1,1-bis(3'-indolyl)-1-(p-anisyl)methane
|
locomotory behavior
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased locomotory behavior] |
1: Mus musculus |
|
2 genes: SLC6A3 | TH
|
1 |
27. |
1,1-bis(3'-indolyl)-1-(p-anisyl)methane
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of I-kappaB kinase/NF-kappaB signaling] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
1 gene: IL1A
|
1 |
28. |
1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole
|
cell proliferation
|
gemcitabine
|
[gemcitabine co-treated with 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole] results in decreased cell proliferation |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
|
1 |
29. |
1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole
|
autophagy
|
3-methyladenine
| gemcitabine
|
3-methyladenine inhibits the reaction [[gemcitabine co-treated with 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole] results in increased autophagy] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
1 gene: XBP1
|
1 |
30. |
1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole
|
autophagy
|
chloroquine diphosphate
| gemcitabine
|
chloroquine diphosphate inhibits the reaction [[gemcitabine co-treated with 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole] results in increased autophagy] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
1 gene: XBP1
|
1 |
31. |
1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole
|
autophagy
|
Acetylcysteine
| gemcitabine
|
Acetylcysteine inhibits the reaction [[gemcitabine co-treated with 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole] results in increased autophagy] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
1 gene: XBP1
|
1 |
32. |
1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole
|
autophagy
|
gemcitabine
|
[gemcitabine co-treated with 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole] results in increased autophagy |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
1 gene: XBP1
|
1 |
33. |
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid
|
microtubule motor activity
|
Glucose
|
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [Glucose results in increased microtubule motor activity] |
1: Mus musculus |
Coronary Vessels | Muscle Cells |
|
1 |
34. |
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid
|
autophagosome maturation
|
Glucose
|
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [Glucose results in increased autophagosome maturation] |
1: Mus musculus |
Coronary Vessels | Muscle Cells |
|
1 |
35. |
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid
|
acrosome reaction
|
NAADP
|
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog affects the reaction [NAADP results in increased acrosome reaction] |
1: Mus musculus |
Spermatozoa |
|
1 |
36. |
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid
|
acrosome reaction
|
|
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog results in increased acrosome reaction |
1: Mus musculus |
Spermatozoa |
|
1 |
37. |
1-(4-chlorobenzoyl)-5-methoxy-2-1H-indole-3-acetic acid 3-(nitrooxymethyl)phenyl ester
|
apoptotic process
|
Celecoxib
|
1-(4-chlorobenzoyl)-5-methoxy-2-1H-indole-3-acetic acid 3-(nitrooxymethyl)phenyl ester inhibits the reaction [Celecoxib results in increased apoptotic process] |
1: Cavia |
Gastric Mucosa | Cells, Cultured |
|
1 |
38. |
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine
|
histamine secretion
|
Trinitrobenzenesulfonic Acid
|
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased histamine secretion] |
1: Rattus norvegicus |
Colon |
|
1 |
39. |
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine
|
leukocyte degranulation
|
N-Formylmethionine Leucyl-Phenylalanine
|
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased leukocyte degranulation] |
1: Homo sapiens |
Granulocytes |
|
1 |
40. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
cellular response to toxic substance
|
|
1-(5-fluoropentyl)-3-(1-naphthoyl)indole affects cellular response to toxic substance |
1: Mus musculus |
Prosencephalon | Neurons | Cells, Cultured |
|
1 |
41. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
cellular response to toxic substance
|
AM 251
| CNR1
|
[AM 251 binds to and results in decreased activity of CNR1 protein] inhibits the reaction [1-(5-fluoropentyl)-3-(1-naphthoyl)indole affects cellular response to toxic substance] |
1: Mus musculus |
Prosencephalon | Neurons | Cells, Cultured |
|
1 |
42. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
positive regulation of neuron death
|
AM 251
| CNR1
|
[AM 251 binds to and results in decreased activity of CNR1 protein] inhibits the reaction [1-(5-fluoropentyl)-3-(1-naphthoyl)indole affects positive regulation of neuron death] |
1: Mus musculus |
Prosencephalon | Neurons | Cells, Cultured |
|
1 |
43. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
positive regulation of neuron apoptotic process
|
|
1-(5-fluoropentyl)-3-(1-naphthoyl)indole affects positive regulation of neuron apoptotic process |
1: Mus musculus |
Prosencephalon | Neurons | Cells, Cultured |
|
1 |
44. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
positive regulation of cell division
|
|
1-(5-fluoropentyl)-3-(1-naphthoyl)indole results in decreased positive regulation of cell division |
1: Homo sapiens |
Lymphocytes | Cells, Cultured |
|
1 |
45. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
positive regulation of cell division
|
|
1-(5-fluoropentyl)-3-(1-naphthoyl)indole analog results in decreased positive regulation of cell division |
1: Homo sapiens |
Lymphocytes | Cells, Cultured |
|
1 |
46. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
drug metabolic process
|
NADP
|
[NADP results in increased drug metabolic process] which results in increased hydroxylation of 1-(5-fluoropentyl)-3-(1-naphthoyl)indole |
1: Homo sapiens |
Microsomes, Liver |
|
1 |
47. |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
|
positive regulation of glutamate secretion, neurotransmission
|
|
1-(5-fluoropentyl)-3-(1-naphthoyl)indole results in increased positive regulation of glutamate secretion, neurotransmission |
1: Mus musculus |
Hippocampus |
|
1 |
48. |
(1-(5-hydropentyl)indol-3-yl)-(1-naphthyl)methanone
|
drug metabolic process
|
NADP
|
[NADP results in increased drug metabolic process] which results in increased hydroxylation of (1-(5-hydropentyl)indol-3-yl)-(1-naphthyl)methanone |
1: Homo sapiens |
Microsomes, Liver |
|
1 |
49. |
(1-(5-hydropentyl)indol-3-yl)-(1-naphthyl)methanone
|
drug metabolic process
|
NAD
|
[NAD results in increased drug metabolic process] which results in increased oxidation of (1-(5-hydropentyl)indol-3-yl)-(1-naphthyl)methanone |
1: Homo sapiens |
Liver | Cytosol |
|
1 |
50. |
(1-(5-hydropentyl)indol-3-yl)-(1-naphthyl)methanone
|
drug metabolic process
|
Fomepizole
| NAD
|
Fomepizole inhibits the reaction [[NAD results in increased drug metabolic process] which results in increased oxidation of (1-(5-hydropentyl)indol-3-yl)-(1-naphthyl)methanone] |
1: Homo sapiens |
Liver | Cytosol |
|
1 |