| 1. |
1,2-dithiol-3-thione
|
response to oxidative stress
|
Hydrogen Peroxide
| NFE2L2
|
[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide affects response to oxidative stress] |
1: Mus musculus |
Embryonic Structures |
35 genes: ALDH1A1 | APOE | APP | BTG1 | CAR3 | CAT | COX1 | CYCS | DDIT3 | EGFR | ETFDH | G6PDX | GCLC | GCLM | GPX2 | GSR | GSS | HMOX1 | JAK2 | KEAP1 | MAP2K1 | MBL2 | NDUFA6 | NQO1 | OXR1 | PEBP1 | PRDX1 | PRDX3 | PSMB5 | SELENOP | STK25 | TRAP1 | TXN2 | TXNIP | TXNRD1
|
1 |
| 2. |
1,2-dithiol-3-thione
|
protein oxidation
|
Hydrogen Peroxide
| NFE2L2
|
[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased protein oxidation] |
1: Mus musculus |
Embryonic Structures |
|
1 |
| 3. |
1,2-dithiol-3-thione
|
glutathione metabolic process
|
Hydrogen Peroxide
| NFE2L2
|
[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased glutathione metabolic process] |
1: Mus musculus |
Embryonic Structures |
16 genes: CTH | G6PDX | GCLC | GCLM | GLO1 | GSR | GSTA1 | GSTA2 | GSTA3 | GSTA5 | GSTK1 | GSTM1 | GSTM2 | GSTP1 | GSTT1 | GSTT2
|
1 |
| 4. |
1,2-dithiol-3-thione
|
cell proliferation
|
irofulven
|
1,2-dithiol-3-thione promotes the reaction [irofulven results in decreased cell proliferation] |
1: Homo sapiens |
HT29 Cells |
40 genes: ADRA1B | CD74 | CDK5 | CITED2 | CREG1 | EGFR | ENPEP | ERBB2 | FGF2 | GAS6 | GLUL | GNB1 | HGF | IGF1 | IL18 | IL1A | IL2RA | INSIG1 | KLF10 | KRT16 | LIPA | LY86 | MAP2K1 | MIF | PDPN | PDZK1 | PRDX1 | PTEN | PTPN6 | PURA | RAP1B | SERPINF1 | SMAD4 | STAT3 | TOP2A | TXNRD1 | UBR5 | VEGFA | ZFP36L1 | ZFP37
|
1 |
| 5. |
13-hydroperoxylinolenic acid
|
membrane lipid catabolic process
|
|
13-hydroperoxylinolenic acid results in increased membrane lipid catabolic process |
1: Rattus norvegicus |
Microsomes, Liver |
|
1 |
| 6. |
13-hydroperoxylinolenic acid
|
membrane lipid catabolic process
|
NAD
|
NAD inhibits the reaction [13-hydroperoxylinolenic acid results in increased membrane lipid catabolic process] |
1: Rattus norvegicus |
Microsomes, Liver |
|
1 |
| 7. |
13-hydroperoxylinolenic acid
|
membrane lipid catabolic process
|
NADP
|
NADP inhibits the reaction [13-hydroperoxylinolenic acid results in increased membrane lipid catabolic process] |
1: Rattus norvegicus |
Microsomes, Liver |
|
1 |
| 8. |
1,4-dithiane
|
eosinophil activation
|
|
1,4-dithiane results in increased eosinophil activation |
1: Rattus norvegicus |
Kidney Tubules |
|
1 |
| 9. |
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid
|
natural killer cell mediated cytotoxicity
|
|
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid affects natural killer cell mediated cytotoxicity |
1: Homo sapiens |
Lymphocytes |
|
1 |
| 10. |
2,2'-dipyridyl disulfide
|
apoptotic process
|
|
2,2'-dipyridyl disulfide results in increased apoptotic process |
1: Rattus norvegicus |
Embryonic Structures | Prosencephalon | Neurons | Cells, Cultured |
4 genes: CASP3 | CASP9 | MAPK1 | MAPK3
|
1 |
| 11. |
2,2'-dipyridyl disulfide
|
apoptotic process
|
Tetraethylammonium
|
Tetraethylammonium inhibits the reaction [2,2'-dipyridyl disulfide results in increased apoptotic process] |
1: Rattus norvegicus |
Embryonic Structures | Prosencephalon | Neurons | Cells, Cultured |
4 genes: CASP3 | CASP9 | MAPK1 | MAPK3
|
1 |
| 12. |
2,2'-dipyridyl disulfide
|
apoptotic process
|
Potassium
|
Potassium inhibits the reaction [2,2'-dipyridyl disulfide results in increased apoptotic process] |
1: Rattus norvegicus |
Embryonic Structures | Prosencephalon | Neurons | Cells, Cultured |
4 genes: CASP3 | CASP9 | MAPK1 | MAPK3
|
1 |
| 13. |
2,2'-dipyridyl disulfide
|
apoptotic process
|
SB 239063
|
SB 239063 inhibits the reaction [2,2'-dipyridyl disulfide results in increased apoptotic process] |
1: Rattus norvegicus |
Embryonic Structures | Prosencephalon | Neurons | Cells, Cultured |
4 genes: CASP3 | CASP9 | MAPK1 | MAPK3
|
1 |
| 14. |
2,2'-dipyridyl disulfide
|
apoptotic process
|
Niacinamide
|
Niacinamide inhibits the reaction [2,2'-dipyridyl disulfide results in increased apoptotic process] |
1: Rattus norvegicus |
Embryonic Structures | Prosencephalon | Neurons | Cells, Cultured |
4 genes: CASP3 | CASP9 | MAPK1 | MAPK3
|
1 |
| 15. |
2,2'-dipyridyl disulfide
|
apoptotic process
|
benzamide
|
benzamide inhibits the reaction [2,2'-dipyridyl disulfide results in increased apoptotic process] |
1: Rattus norvegicus |
Embryonic Structures | Prosencephalon | Neurons | Cells, Cultured |
4 genes: CASP3 | CASP9 | MAPK1 | MAPK3
|
1 |
| 16. |
2,2'-dipyridyl disulfide
|
reactive oxygen species biosynthetic process
|
|
2,2'-dipyridyl disulfide results in increased reactive oxygen species biosynthetic process |
1: Rattus norvegicus |
Myocytes, Cardiac | Cells, Cultured |
|
1 |
| 17. |
2,2'-dipyridyl disulfide
|
reactive oxygen species biosynthetic process
|
polydatin
|
polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased reactive oxygen species biosynthetic process] |
1: Rattus norvegicus |
Myocytes, Cardiac | Cells, Cultured |
|
1 |
| 18. |
2,2'-dipyridyl disulfide
|
lipid catabolic process
|
|
2,2'-dipyridyl disulfide results in increased lipid catabolic process |
1: Rattus norvegicus |
Myocytes, Cardiac | Cells, Cultured |
|
1 |
| 19. |
2,2'-dipyridyl disulfide
|
lipid catabolic process
|
polydatin
|
polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased lipid catabolic process] |
1: Rattus norvegicus |
Myocytes, Cardiac | Cells, Cultured |
|
1 |
| 20. |
2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester
|
cell proliferation
|
|
2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester results in decreased cell proliferation |
1: Homo sapiens |
Prostate | Cell Line, Tumor |
1 gene: CTNNB1
|
1 |
| 21. |
2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester
|
apoptotic process
|
|
2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester results in increased apoptotic process |
1: Homo sapiens |
Prostate | Cell Line, Tumor |
1 gene: CASP3
|
1 |
| 22. |
2-amino-6-boronohexanoic acid
|
positive regulation of apoptotic process
|
Oxygen
|
2-amino-6-boronohexanoic acid inhibits the reaction [Oxygen results in increased positive regulation of apoptotic process] |
1: Bos taurus |
Retina | Endothelial Cells |
|
1 |
| 23. |
2-amino-6-boronohexanoic acid
|
cell proliferation
|
AGT
|
2-amino-6-boronohexanoic acid inhibits the reaction [AGT protein results in increased cell proliferation] |
1: Rattus norvegicus |
Aorta | Myocytes, Smooth Muscle |
|
1 |
| 24. |
2-aminoethoxydiphenylborane
|
calcium ion homeostasis
|
cadmium acetate
|
2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate affects calcium ion homeostasis] |
1: Rattus norvegicus |
Skull | Osteoblasts | Cells, Cultured |
|
1 |
| 25. |
2-aminoethoxydiphenylborane
|
cell proliferation
|
cadmium acetate
|
2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in decreased cell proliferation] |
1: Rattus norvegicus |
Skull | Osteoblasts | Cells, Cultured |
2 genes: BAX | BCL2
|
1 |
| 26. |
2-aminoethoxydiphenylborane
|
apoptotic process
|
cadmium acetate
|
2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in increased apoptotic process] |
1: Rattus norvegicus |
Skull | Osteoblasts | Cells, Cultured |
4 genes: BAX | BCL2 | CASP12 | CASP3
|
1 |
| 27. |
2-aminoethoxydiphenyl borate
|
calcium-mediated signaling
|
Morphine
|
2-aminoethoxydiphenyl borate inhibits the reaction [Morphine results in increased calcium-mediated signaling] |
1: Rattus norvegicus |
Myocytes, Cardiac | Cells, Cultured |
6 genes: CXCL8 | EDN1 | EDNRB | EIF2AK3 | GRM1 | TNF
|
1 |
| 28. |
2-aminoethoxydiphenyl borate
|
histamine secretion mediated by immunoglobulin
|
GAST
|
2-aminoethoxydiphenyl borate inhibits the reaction [GAST protein results in increased histamine secretion mediated by immunoglobulin] |
1: Rattus norvegicus |
Stomach | Enterochromaffin-like Cells | Cells, Cultured |
|
1 |
| 29. |
2-aminoethoxydiphenyl borate
|
ion transport
|
GAST
|
2-aminoethoxydiphenyl borate inhibits the reaction [GAST protein results in increased ion transport] |
1: Rattus norvegicus |
Stomach | Enterochromaffin-like Cells | Cells, Cultured |
12 genes: ITPR1 | ITPR2 | ITPR3 | ORAI1 | TRPA1 | TRPC4 | TRPC5 | TRPM2 | TRPM7 | TRPV1 | TRPV2 | TRPV3
|
1 |
| 30. |
2-aminoethoxydiphenyl borate
|
apoptotic process
|
LGALS9
|
2-aminoethoxydiphenyl borate inhibits the reaction [LGALS9 protein results in increased apoptotic process] |
1: Homo sapiens |
T-Lymphocytes | Cell Line, Tumor |
14 genes: AKT1 | CASP12 | CASP3 | CASP9 | CASR | DDIT3 | IFNG | IL1B | ITPR1 | MAPK1 | MAPK3 | RPS6KB1 | TNF | TRPV2
|
1 |
| 31. |
2-aminoethoxydiphenyl borate
|
cell proliferation
|
|
2-aminoethoxydiphenyl borate results in decreased cell proliferation |
1: Mus musculus |
Cerebral Arteries | Myocytes, Smooth Muscle |
8 genes: AKT1 | CDK4 | CHRM1 | CYP1A1 | PCNA | TGFB1 | TNF | VEGFA
|
1 |
| 32. |
2-aminoethoxydiphenyl borate
|
calcium-mediated signaling
|
Testosterone
|
2-aminoethoxydiphenyl borate inhibits the reaction [Testosterone results in increased calcium-mediated signaling] |
1: Homo sapiens |
Neurons | Cell Line, Tumor |
6 genes: CXCL8 | EDN1 | EDNRB | EIF2AK3 | GRM1 | TNF
|
1 |
| 33. |
2-aminoethoxydiphenyl borate
|
apoptotic process
|
Testosterone
|
2-aminoethoxydiphenyl borate inhibits the reaction [Testosterone results in increased apoptotic process] |
1: Homo sapiens |
Neurons | Cell Line, Tumor |
14 genes: AKT1 | CASP12 | CASP3 | CASP9 | CASR | DDIT3 | IFNG | IL1B | ITPR1 | MAPK1 | MAPK3 | RPS6KB1 | TNF | TRPV2
|
1 |
| 34. |
2-aminoethoxydiphenyl borate
|
apoptotic DNA fragmentation
|
Testosterone
|
2-aminoethoxydiphenyl borate inhibits the reaction [Testosterone results in increased apoptotic DNA fragmentation] |
1: Homo sapiens |
Neurons | Cell Line, Tumor |
1 gene: CASP3
|
1 |
| 35. |
2-aminoethoxydiphenyl borate
|
cellular calcium ion homeostasis
|
arsenic trioxide
|
2-aminoethoxydiphenyl borate inhibits the reaction [arsenic trioxide affects cellular calcium ion homeostasis] |
1: Homo sapiens |
Neurons | Cell Line, Tumor |
6 genes: ATF4 | CALCA | CASR | CCL1 | EDN3 | TGFB1
|
1 |
| 36. |
2-aminoethoxydiphenyl borate
|
cellular calcium ion homeostasis
|
arsenic trioxide
|
2-aminoethoxydiphenyl borate inhibits the reaction [arsenic trioxide affects cellular calcium ion homeostasis] |
1: Homo sapiens |
HEK293 Cells |
6 genes: ATF4 | CALCA | CASR | CCL1 | EDN3 | TGFB1
|
1 |
| 37. |
2-aminoethoxydiphenyl borate
|
calcium-mediated signaling
|
|
2-aminoethoxydiphenyl borate affects calcium-mediated signaling |
1: Mus musculus |
Testis | Arteries | Muscle, Smooth, Vascular |
6 genes: CXCL8 | EDN1 | EDNRB | EIF2AK3 | GRM1 | TNF
|
1 |
| 38. |
2-aminoethoxydiphenyl borate
|
apoptotic process
|
Indomethacin
|
2-aminoethoxydiphenyl borate inhibits the reaction [Indomethacin results in increased apoptotic process] |
1: Homo sapiens |
Caco-2 Cells |
14 genes: AKT1 | CASP12 | CASP3 | CASP9 | CASR | DDIT3 | IFNG | IL1B | ITPR1 | MAPK1 | MAPK3 | RPS6KB1 | TNF | TRPV2
|
1 |
| 39. |
2-aminoethoxydiphenyl borate
|
release of cytochrome c from mitochondria
|
Indomethacin
|
2-aminoethoxydiphenyl borate inhibits the reaction [Indomethacin results in increased release of cytochrome c from mitochondria] |
1: Homo sapiens |
Caco-2 Cells |
|
1 |
| 40. |
2-aminoethoxydiphenyl borate
|
cell proliferation
|
Indomethacin
|
2-aminoethoxydiphenyl borate inhibits the reaction [Indomethacin results in decreased cell proliferation] |
1: Homo sapiens |
Caco-2 Cells |
8 genes: AKT1 | CDK4 | CHRM1 | CYP1A1 | PCNA | TGFB1 | TNF | VEGFA
|
1 |
| 41. |
2-aminoethoxydiphenyl borate
|
cell death
|
Ozone
|
2-aminoethoxydiphenyl borate inhibits the reaction [Ozone results in increased cell death] |
1: Rattus norvegicus |
Spinal Cord | Neurons | Cells, Cultured |
|
1 |
| 42. |
2-aminoethoxydiphenyl borate
|
endoplasmic reticulum calcium ion homeostasis
|
Ozone
|
2-aminoethoxydiphenyl borate inhibits the reaction [Ozone affects endoplasmic reticulum calcium ion homeostasis] |
1: Rattus norvegicus |
Spinal Cord | Neurons | Cells, Cultured |
1 gene: ITPR1
|
1 |
| 43. |
2-aminoethoxydiphenyl borate
|
regulation of cytosolic calcium ion concentration
|
usnic acid
|
2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid affects regulation of cytosolic calcium ion concentration] |
1: Homo sapiens |
Hep G2 Cells |
1 gene: CALCA
|
1 |
| 44. |
2-aminoethoxydiphenyl borate
|
activation of cysteine-type endopeptidase activity
|
Indomethacin
|
2-aminoethoxydiphenyl borate inhibits the reaction [Indomethacin results in increased activation of cysteine-type endopeptidase activity] |
1: Homo sapiens |
Caco-2 Cells |
|
1 |
| 45. |
2-aminoethoxydiphenyl borate
|
positive regulation of release of sequestered calcium ion into cytosol
|
Indomethacin
|
2-aminoethoxydiphenyl borate inhibits the reaction [Indomethacin results in increased positive regulation of release of sequestered calcium ion into cytosol] |
1: Homo sapiens |
Caco-2 Cells |
|
1 |
| 46. |
2-aminoethoxydiphenyl borate
|
mitochondrial calcium ion transmembrane transport
|
Indomethacin
|
2-aminoethoxydiphenyl borate inhibits the reaction [Indomethacin results in increased mitochondrial calcium ion transmembrane transport] |
1: Homo sapiens |
Caco-2 Cells | Mitochondria |
|
1 |
| 47. |
2-aminoethoxydiphenyl borate
|
positive regulation of release of sequestered calcium ion into cytosol
|
Lead
|
2-aminoethoxydiphenyl borate inhibits the reaction [Lead results in increased positive regulation of release of sequestered calcium ion into cytosol] |
1: Rattus norvegicus |
Kidney Tubules, Proximal | Cells, Cultured |
|
1 |
| 48. |
2-aminoethoxydiphenyl borate
|
negative regulation of endoplasmic reticulum calcium ion concentration
|
Lead
|
2-aminoethoxydiphenyl borate inhibits the reaction [Lead results in increased negative regulation of endoplasmic reticulum calcium ion concentration] |
1: Rattus norvegicus |
Kidney Tubules, Proximal | Cells, Cultured |
|
1 |
| 49. |
2-aminoethoxydiphenyl borate
|
positive regulation of mitochondrial calcium ion concentration
|
Lead
|
2-aminoethoxydiphenyl borate inhibits the reaction [Lead results in increased positive regulation of mitochondrial calcium ion concentration] |
1: Rattus norvegicus |
Kidney Tubules, Proximal | Cells, Cultured |
|
1 |
| 50. |
2-aminoethoxydiphenyl borate
|
positive regulation of apoptotic process
|
Lead
|
2-aminoethoxydiphenyl borate inhibits the reaction [Lead results in increased positive regulation of apoptotic process] |
1: Rattus norvegicus |
Kidney Tubules, Proximal | Cells, Cultured |
19 genes: AKT1 | ATF4 | CASP12 | CASP3 | CASP9 | CDK4 | CREB1 | CYP1B1 | DDIT3 | IFNG | IL1B | IL6 | NOS3 | PLA2G4A | PTGS2 | TGFB1 | TNF | TRPM7 | TRPV1
|
1 |
Illuminating how chemicals affect human health.
Inorganic Chemicals