1. |
1,2-dithiol-3-thione
|
response to oxidative stress
|
Hydrogen Peroxide
| NFE2L2
|
[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide affects response to oxidative stress] |
1: Mus musculus |
Embryonic Structures |
35 genes: ALDH1A1 | APOE | APP | BTG1 | CAR3 | CAT | COX1 | CYCS | DDIT3 | EGFR | ETFDH | G6PDX | GCLC | GCLM | GPX2 | GSR | GSS | HMOX1 | JAK2 | KEAP1 | MAP2K1 | MBL2 | NDUFA6 | NQO1 | OXR1 | PEBP1 | PRDX1 | PRDX3 | PSMB5 | SELENOP | STK25 | TRAP1 | TXN2 | TXNIP | TXNRD1
|
1 |
2. |
1,2-dithiol-3-thione
|
protein oxidation
|
Hydrogen Peroxide
| NFE2L2
|
[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased protein oxidation] |
1: Mus musculus |
Embryonic Structures |
|
1 |
3. |
1,2-dithiol-3-thione
|
glutathione metabolic process
|
Hydrogen Peroxide
| NFE2L2
|
[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased glutathione metabolic process] |
1: Mus musculus |
Embryonic Structures |
16 genes: CTH | G6PDX | GCLC | GCLM | GLO1 | GSR | GSTA1 | GSTA2 | GSTA3 | GSTA5 | GSTK1 | GSTM1 | GSTM2 | GSTP1 | GSTT1 | GSTT2
|
1 |
4. |
1,2-dithiol-3-thione
|
cell proliferation
|
irofulven
|
1,2-dithiol-3-thione promotes the reaction [irofulven results in decreased cell proliferation] |
1: Homo sapiens |
HT29 Cells |
36 genes: ADRA1B | CD74 | CDK5 | CITED2 | EGFR | ENPEP | ERBB2 | FGF2 | GAS6 | GLUL | GNB1 | HGF | IGF1 | IL18 | IL1A | IL2RA | KLF10 | KRT16 | LIPA | MAP2K1 | MIF | PDPN | PDZK1 | PRDX1 | PTEN | PTPN6 | PURA | RAP1B | SERPINF1 | SMAD4 | STAT3 | TOP2A | TXNRD1 | VEGFA | ZFP36L1 | ZFP37
|
1 |
5. |
13-hydroperoxylinolenic acid
|
membrane lipid catabolic process
|
|
13-hydroperoxylinolenic acid results in increased membrane lipid catabolic process |
1: Rattus norvegicus |
Microsomes, Liver |
|
1 |
6. |
13-hydroperoxylinolenic acid
|
membrane lipid catabolic process
|
NAD
|
NAD inhibits the reaction [13-hydroperoxylinolenic acid results in increased membrane lipid catabolic process] |
1: Rattus norvegicus |
Microsomes, Liver |
|
1 |
7. |
13-hydroperoxylinolenic acid
|
membrane lipid catabolic process
|
NADP
|
NADP inhibits the reaction [13-hydroperoxylinolenic acid results in increased membrane lipid catabolic process] |
1: Rattus norvegicus |
Microsomes, Liver |
|
1 |
8. |
1,4-dithiane
|
eosinophil activation
|
|
1,4-dithiane results in increased eosinophil activation |
1: Rattus norvegicus |
Kidney Tubules |
|
1 |
9. |
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid
|
natural killer cell mediated cytotoxicity
|
|
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid affects natural killer cell mediated cytotoxicity |
1: Homo sapiens |
Lymphocytes |
|
1 |
10. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Propofol
|
[Propofol co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased vasoconstriction |
1: Canis lupus familiaris |
Lung |
2 genes: AVP | EDN1
|
2 |
11. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
2: Canis lupus familiaris | Rattus norvegicus |
Lung |
2 genes: AVP | EDN1
|
3 |
12. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
1: Homo sapiens |
Placenta | Arteries |
2 genes: AVP | EDN1
|
2 |
13. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Pinacidil
|
Pinacidil inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Homo sapiens |
Placenta | Arteries |
2 genes: AVP | EDN1
|
1 |
14. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Ropivacaine
|
Ropivacaine inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Lung |
2 genes: AVP | EDN1
|
1 |
15. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
1: Homo sapiens |
Myometrium | Blood Vessels |
2 genes: AVP | EDN1
|
1 |
16. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Sildenafil Citrate
|
Sildenafil Citrate inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Homo sapiens |
Myometrium | Blood Vessels |
2 genes: AVP | EDN1
|
1 |
17. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
2: Ovis aries | Rattus norvegicus |
Blood Vessels |
2 genes: AVP | EDN1
|
2 |
18. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
ridogrel
|
ridogrel inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Blood Vessels |
2 genes: AVP | EDN1
|
1 |
19. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
sulotroban
|
sulotroban inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Blood Vessels |
2 genes: AVP | EDN1
|
1 |
20. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
ion transport
|
Flunarizine
| vasoconstriction
|
[Flunarizine results in decreased ion transport] inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Blood Vessels |
|
1 |
21. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Flunarizine
| ion transport
|
[Flunarizine results in decreased ion transport] inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Blood Vessels |
2 genes: AVP | EDN1
|
1 |
22. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
ion transport
|
Nifedipine
| vasoconstriction
|
[Nifedipine results in decreased ion transport] inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Blood Vessels |
|
1 |
23. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
ion transport
| Nifedipine
|
[Nifedipine results in decreased ion transport] inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Blood Vessels |
2 genes: AVP | EDN1
|
1 |
24. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
2: Canis lupus familiaris | Rattus norvegicus |
Lung | Blood Vessels |
2 genes: AVP | EDN1
|
4 |
25. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
EDN1
|
[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in increased vasodilation |
|
Lung | Blood Vessels |
1 gene: TNF
|
1 |
26. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
EDN3
|
[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN3 protein] results in increased vasodilation |
|
Lung | Blood Vessels |
1 gene: TNF
|
1 |
27. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
sarafotoxins s6
|
[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with sarafotoxins s6] results in increased vasodilation |
1: Rattus norvegicus |
Lung | Blood Vessels |
1 gene: TNF
|
1 |
28. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
Bosentan
| EDN1
|
Bosentan inhibits the reaction [[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in increased vasodilation] |
|
Lung | Blood Vessels |
1 gene: TNF
|
1 |
29. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
EDN1
| Indomethacin
|
Indomethacin inhibits the reaction [[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in increased vasodilation] |
|
Lung | Blood Vessels |
1 gene: TNF
|
1 |
30. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
2: Mus musculus | Sus scrofa |
Basilar Artery |
2 genes: AVP | EDN1
|
2 |
31. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
4: Canis lupus familiaris | Homo sapiens | Rattus norvegicus | Sus scrofa |
Coronary Vessels |
2 genes: AVP | EDN1
|
7 |
32. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Irbesartan
|
Irbesartan inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Canis lupus familiaris |
Coronary Vessels |
2 genes: AVP | EDN1
|
1 |
33. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Losartan
|
Losartan inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Canis lupus familiaris |
Coronary Vessels |
2 genes: AVP | EDN1
|
1 |
34. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
1: Rattus norvegicus |
Hindlimb | Blood Vessels |
2 genes: AVP | EDN1
|
1 |
35. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Irbesartan
|
Irbesartan inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Hindlimb | Blood Vessels |
2 genes: AVP | EDN1
|
1 |
36. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
AGT
|
AGT protein inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
|
Coronary Vessels |
2 genes: AVP | EDN1
|
1 |
37. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
AGT
| PD 123319
|
PD 123319 inhibits the reaction [AGT protein inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction]] |
|
Coronary Vessels |
2 genes: AVP | EDN1
|
1 |
38. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
regulation of blood pressure
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased regulation of blood pressure |
1: Canis lupus familiaris |
Lung | Blood Vessels |
4 genes: EDN1 | NOS2 | TAC1 | TACR1
|
1 |
39. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
regulation of blood pressure
|
beraprost
|
beraprost inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased regulation of blood pressure] |
1: Canis lupus familiaris |
Lung | Blood Vessels |
4 genes: EDN1 | NOS2 | TAC1 | TACR1
|
1 |
40. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
regulation of blood pressure
|
Nitroglycerin
|
Nitroglycerin inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased regulation of blood pressure] |
1: Canis lupus familiaris |
Lung | Blood Vessels |
4 genes: EDN1 | NOS2 | TAC1 | TACR1
|
1 |
41. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
regulation of blood pressure
|
Alprostadil
|
Alprostadil promotes the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased regulation of blood pressure] |
1: Canis lupus familiaris |
Lung | Blood Vessels |
4 genes: EDN1 | NOS2 | TAC1 | TACR1
|
1 |
42. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
regulation of blood pressure
|
Nifedipine
|
Nifedipine promotes the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased regulation of blood pressure] |
1: Canis lupus familiaris |
Lung | Blood Vessels |
4 genes: EDN1 | NOS2 | TAC1 | TACR1
|
1 |
43. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
regulation of heart rate
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in decreased regulation of heart rate |
1: Canis lupus familiaris |
Heart |
1 gene: OXT
|
1 |
44. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
beraprost
|
beraprost inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Canis lupus familiaris |
Pulmonary Artery |
2 genes: AVP | EDN1
|
1 |
45. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction |
2: Canis lupus familiaris | Rattus norvegicus |
Pulmonary Artery |
2 genes: AVP | EDN1
|
2 |
46. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Staurosporine
|
Staurosporine inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction] |
1: Rattus norvegicus |
Coronary Vessels |
2 genes: AVP | EDN1
|
1 |
47. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasoconstriction
|
Isoflurane
| Staurosporine
|
Isoflurane inhibits the reaction [Staurosporine inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction]] |
1: Rattus norvegicus |
Coronary Vessels |
2 genes: AVP | EDN1
|
1 |
48. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
Acetylcholine
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [Acetylcholine results in increased vasodilation] |
1: Canis lupus familiaris |
Lung | Blood Vessels |
1 gene: TNF
|
1 |
49. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
KNG1
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [KNG1 protein alternative form results in increased vasodilation] |
|
Lung | Blood Vessels |
1 gene: TNF
|
1 |
50. |
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
vasodilation
|
Isoproterenol
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid affects the reaction [Isoproterenol results in increased vasodilation] |
1: Canis lupus familiaris |
Lung | Blood Vessels |
1 gene: TNF
|
1 |