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Chemical Insulin

Name Insulin
Equivalent Terms Chain, Insulin B | Iletin | Insulin A Chain | Insulin B Chain | Insulin, Regular | Insulin, Sodium | Insulin, Soluble | Novolin | Regular Insulin | Sodium Insulin | Soluble Insulin
Definition A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Curation Status No gene interactions have been curated for this chemical yet.
MeSH® ID D007328
External Links

Top ↑ Ancestors

1. ChemicalsHormones, Hormone Substitutes, and Hormone Antagonists Has associated genes Has associated diseases Has associated exposure references Hormones Has associated genes Has associated diseases Has associated exposure references Peptide Hormones Has associated genes Has associated diseases Has associated exposure references Pancreatic Hormones Has associated genes Has associated diseases Insulins Has associated genes Has associated diseases Proinsulin Has associated genes Has associated diseases Insulin Has associated diseases
2. ChemicalsAmino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated exposure references Peptides Has associated genes Has associated diseases Has associated exposure references Peptide Hormones Has associated genes Has associated diseases Has associated exposure references Pancreatic Hormones Has associated genes Has associated diseases Insulins Has associated genes Has associated diseases Proinsulin Has associated genes Has associated diseases Insulin Has associated diseases

Top ↑ Descendants

Insulin Has associated diseases
  2-(4-azidosalicylamido)ethyl-1,3-dithiopropionate insulin
  2,4-dinitrophenol-insulin A chain-fluorescein conjugate
  ((2-sulfo)-9-fluorenylmethoxycarbonyl)3-insulin
  acetylinsulin
  alpha-2-macroglobulin-insulin complex
  amphioxus insulin-like peptide
  ATP-insulin conjugates
  Auron-Misheil-Therapy
  B22 Glu des-B30 insulin
  B27 Lys destripeptide insulin
  B29-biotin insulin
  benzoylphenylalanine(B25)insulin
  B-insulin
  bis(9-fluorenylmethoxycarbonyl)insulin
  BSA-insulin-chlorin e(6) conjugate
  cholera toxin B-insulin conjugate
  colloidal gold-insulin complex
  DKP-insulin
  DP 432
  Exubera
  glucose-insulin-potassium cardioplegic solution Has associated diseases
  glycerol-insulin
  Growth Factors, Combined Defect of
  hexyl-insulin monoconjugate 2
  ins-1 protein, C elegans
  Ins1 protein, mouse
  Ins2 protein, mouse
  insulin, (2,4,6-trinitrophenyl)sulfonyl(Al)-
  insulin, 2,7-diaminosuberoyl, N(alpha)(A1), N(epsilon)(B29)-
  insulin, (2-nitro-4-azidophenyl)(A1)-
  insulin, (2-nitro-4-azidophenylacetyl) (B29)-
  insulin, (2-nitro-4-azidophenylacetyl)(B2)-des-Phe(B1)-
  insulin, (2-nitro-4-azidophenyl)-Gly(B29)-
  insulin, (2-nitro-4-trimethylammoniophenyl)(A1)-
  insulin, (2-nitro-azidophenylacetyl)(B1)-
  insulin, 3,5-diiodo-Tyr(A19)-
  insulin, 3-iodo-Tyr(A14)-
  insulin, 3-(N-phenylacetyl)-
  insulin, 4-azido-2-nitrophenyl-
  insulin, 4-azidobenzoyl(B29)-
  insulin, 4-(azidophenylacetyl)-2,4-diaminobutyric acid(A1)-
  insulin, 4-fluorophenylalanine(A19)-
  insulin, 4-succinylamidophenylarabinopyranoside-
  insulin, 4-succinylamidophenylglucopyranoside-
  insulin, 4-succinylamidophenylmannopyranoside-
  insulin, 6-(4-fluorobenzoyl)aminohexanoylphenylalanyl(B1)-
  insulin, A(27)-B-insulin-like growth factor I
  insulin, A8H,B25N,B27E,desB30-
  insulin, adipoyl-Arg(B22)-
  insulin, Aib(21) B-chain-
  insulin, Aib(22) B-chain-
  insulin, Ala(A1)-
  insulin, Ala(B0)-
  insulin, Ala(B24)-
  insulin-a protein, zebrafish
  insulin, Arg(B0)-
  insulin, Arg(B22)-
  insulin, Arg(B29)-
  insulin, Arg(B31)-
  insulin, Arg(B31,B32)-
  insulin, Asn(21)-diethylamide(A)-
  insulin, Asn(B10)-
  insulin, Asn(B12)-
  insulin, AsnNH2(A21)-
  insulin, Asp(B10)- Has associated diseases
  insulin, Asp(B9)-Glu(B27)-
  insulin, Asp-imide(A21)-
  insulin, azoisobutyryl-
  insulin, B(1-29)-valyl-glycyl-leucyl-seryl-seryl-glycyl-glutaminyl-A(1-21)-A18Q-
  insulin, B1-(4-azidosalicyloyl)-(B1-biocytin,B2-lysine)-
  insulin, (B1)-des-Phe-
  insulin B (20-30)
  insulin B (22-30)
  insulin B (9-23)
  insulin B (9-30)
  insulin B-chain tetrapeptide amide B22-B25
  insulin, biotinyl-
  insulin, bis(tert-butyloxycarbonyl)desoctapeptide-phenylhydrazide-
  insulin-b protein, zebrafish
  insulin, butyrimidylpyridine disulfide-
  insulin, carbonyl-bis-Met,N(alphal),N(epsilon)(B29)-
  insulin, carboxymethyl-His-
  insulin, citraconyl-
  insulin covalent aggregate
  insulin crosslinked to the catalytic fragment A of diphtheria toxin
  insulin, depot-
  insulin, des-Ala-
  insulin, desamido-
  insulin, desamido (A21)-
  insulin, desamido (B-3)
  insulin, des-Asn(21)-Cys(20)-2,2,2-trifluoroethylamide(A)-
  insulin, des-Asn(21)-Cys(20)-ethylamide(A)-
  insulin, des-Asn(21)-Cys(20)-isopropylamide(A)-
  insulin, des-Asn(21)-CysNH2(20)(A)-
  insulin, des-Asn(A21)-des-Ala(B30)-
  insulin, des-Gly(1A)-N-((trimethylammonio)acetyl)Ile(2A)-
  insulin, des-Gly(A1)-
  insulin, des-Gly(A1)-des-Phe(B1)-
  insulin, des(heptapeptide)(B24-B30)-
  insulin, des(hexapeptide)(B25-30)-Ala(B23)-
  insulin, deshexapeptide(B25-B30)-
  insulin, desoctapeptide-
  insulin, des(pentapeptide)(B1-B5)-
  insulin, despentapeptide(B26-B30)-
  insulin, despentapeptide (B26-B30)-HisNH2(B25)-
  insulin, despentapeptide (B26-B30)-PheNH2(B25)-
  insulin, despentapeptide (B26-B30)-TyrNH2(B25)-
  insulin, des-Phe(B1)-des-Val(B2)-
  insulin, des(tetrapeptide)(B1-B4)-
  insulin, des(tetrapeptide)(B27-B30)-
  insulin, dethiobiotinyl-
  insulin-dextran
  insulin, diacetyl(A1-B29)-
  insulin, dicarbain(A7,B7)-
  insulin, dicitraconyl Gly(A1)Phe(B1)-
  insulin, dihydroxycyclohexylene-
  insulin dimers
  insulin, disulfide-des-Ala(B30)-
  insulin, dodecoy(A1-B29)-
  insulin, fluorescein-isothiocyanated-
  insulin, fluoresceinthiocarbamyl(B29)-
  insulin fragment A(14-21)-B(17-30)
  insulin, Gln(A8)-
  insulin, Gln(B13)-
  insulin, Gln(B30)-
  insulin, Glu(21) B-chain-
  insulin, Glu(A8)-
  insulin glulisine
  insulin, Gly(A1)-
  insulin, glycosylated
  insulin, hexamethylester-
  insulin, His(B16)-
  insulin, iodo-
  insulin, Leu(A19)-
  insulin, Leu(A3)-
  insulin, Leu(B24)-
  insulin, Leu(B24,B25)-
  insulin, Leu(B25)-
  insulin, Leu(B30)-
  insulin-like protein 6-kDa, Panulirus argus
  insulin, Lys(B29)-(N(epsilon)-myristoyl)-des(b30)
  insulin, lysyl(B31)-arginyl(B32)-
  insulin, methoxy-
  insulin, N(alpha)(B1), biotinyl-epsilon-aminocaproyl-
  insulin, N(epsilon)-palmitoyl Lys(B29)-
  insulin, Nle(A2)-
  insulin, Nle(B17)-
  insulin, N-Me-Ile(2A)-
  insulin, N-methylpyridinium
  insulin, N-Me-Val(3A)-
  insulin, N,N-bis(methylsulfonylethoxycarbonyl)-
  insulin, octadeutero-Phe(B1)-octadeutero-Val(B2)-
  insulin, Phe(A14)-
  insulin, Phe(A19)-
  insulin, Phe(B1)-
  insulin, Phe(B24)-
  insulin, polyethylene glycol(B1)-
  insulin, Pro(B21)-
View node Insulin, Regular, Human
View node Insulin, Regular, Pork
  insulin-related factor
  insulin, Sar(9A)-
  insulin, Ser(A6,A11)-
  insulin, Ser(B24)-
  insulin, Ser(B25)-
  insulin, single chain des-(B30)-
  insulin, tetrakis(3-nitro-Tyr)-
  insulin, trifluoroacetyl-
  insulin, tri-Lys-
  insulin, triphthaloyl-
  insulin, tris(N-methylpyridinium)-
  insulin, Trp(A1)-
  insulin, Trp(A19)-
  insulin, Trp(B1)-
  Insulin, Ultratard
  insulin, W(B28),P(B29)-
  iodo(A14-tyrosyl)insulin
  Leydig insulin-like protein
  Lys(B29)(N-carboxynonadecanoyl)-des(B30) human insulin
  Lys(B29)-N(epsilon)-lithocholoyl-gamma-Glu des(b30) insulin
  NBC-insulin
  NBI6024
  N(epsilon)B29-(4-azidosalicyloyl) insulin
  N(epsilon)B29-(4-azidotetrafluorobenzoyl-biocytinyl) insulin
  neutral protamine lispro
  NovoSol Basal insulin
  ORMD-0801
  PIns peptide
  preproinsulin
  Somah
  sulfated beef insulin
  thyroxyl-insulin
  University of Wisconsin-lactobionate solution