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Chemical Isoquinolines

1–50 of 573 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline cell proliferation 1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline metabolite results in decreased cell proliferation 1: Homo sapiens Neurons | Cell Line, Tumor   1
2. 1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline cell proliferation 1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in decreased cell proliferation 1: Homo sapiens Neurons | Cell Line, Tumor   1
3. 1,5-dihydroxyisoquinoline cell death Hydrogen Peroxide 1,5-dihydroxyisoquinoline inhibits the reaction [Hydrogen Peroxide results in increased cell death] 1: Rattus norvegicus Neurons | Cell Line, Tumor   1
4. 1,5-dihydroxyisoquinoline cell death Deferoxamine | Hydrogen Peroxide [1,5-dihydroxyisoquinoline co-treated with Deferoxamine] inhibits the reaction [Hydrogen Peroxide results in increased cell death] 1: Rattus norvegicus Neurons | Cell Line, Tumor   1
5. 1,5-dihydroxyisoquinoline cell death anhydrovitamin A 1,5-dihydroxyisoquinoline inhibits the reaction [anhydrovitamin A results in increased cell death] 1: Homo sapiens Jurkat Cells   1
6. 1,5-dihydroxyisoquinoline cell differentiation Tretinoin 1,5-dihydroxyisoquinoline inhibits the reaction [Tretinoin results in increased cell differentiation] 1: Homo sapiens Neutrophils   1
7. 1,5-dihydroxyisoquinoline apoptotic process Tretinoin [1,5-dihydroxyisoquinoline co-treated with Tretinoin] results in increased apoptotic process 1: Homo sapiens Neutrophils
2 genes: BCL2 | PARP1
1
8. 1,5-dihydroxyisoquinoline apoptotic DNA fragmentation Tretinoin [1,5-dihydroxyisoquinoline co-treated with Tretinoin] results in increased apoptotic DNA fragmentation 1: Homo sapiens Neutrophils   1
9. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one protein poly-ADP-ribosylation Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased protein poly-ADP-ribosylation] 1: Mus musculus Lung 1 gene: PARP1 1
10. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one positive regulation of collagen biosynthetic process Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased positive regulation of collagen biosynthetic process] 1: Mus musculus Lung 1 gene: TGFB1 1
11. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one positive regulation of lung goblet cell differentiation Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased positive regulation of lung goblet cell differentiation] 1: Mus musculus Lung | Epithelium   1
12. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one DNA modification Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased DNA modification] 1: Mus musculus Lung | Epithelium   1
13. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one DNA modification 8-oxo-7-hydrodeoxyguanosine | Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [[Bleomycin results in increased DNA modification] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine] 1: Mus musculus Lung | Epithelium   1
14. 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone apoptotic process Arsenic Trioxide | phytosphingosine 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased apoptotic process] 1: Homo sapiens U937 Cells
6 genes: AIFM1 | BAX | CASP3 | CASP9 | MAPK14 | PARP1
1
15. 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone regulation of mitochondrial membrane potential Arsenic Trioxide | phytosphingosine 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in decreased regulation of mitochondrial membrane potential] 1: Homo sapiens U937 Cells 1 gene: BAX 1
16. 4-amino-1,8-naphthalimide G2 DNA damage checkpoint Arsenic Trioxide 4-amino-1,8-naphthalimide inhibits the reaction [Arsenic Trioxide results in increased G2 DNA damage checkpoint] 1: Homo sapiens Hep G2 Cells   1
17. 4-amino-1,8-naphthalimide positive regulation of DNA repair 4-amino-1,8-naphthalimide results in decreased positive regulation of DNA repair 1: Homo sapiens Hep G2 Cells   1
18. 4-amino-1,8-naphthalimide positive regulation of apoptotic process Arsenic Trioxide 4-amino-1,8-naphthalimide promotes the reaction [Arsenic Trioxide results in increased positive regulation of apoptotic process] 1: Homo sapiens Hep G2 Cells
6 genes: ATM | BAX | CASP3 | NOS2 | PRKDC | RELA
1
19. 4-amino-1,8-naphthalimide cell proliferation Arsenic Trioxide 4-amino-1,8-naphthalimide promotes the reaction [Arsenic Trioxide results in decreased cell proliferation] 1: Homo sapiens Hep G2 Cells
4 genes: BAX | BCL2 | PRKDC | XRCC5
1
20. 4-amino-1,8-naphthalimide cell proliferation Arsenic Trioxide | Lipopolysaccharides Lipopolysaccharides inhibits the reaction [4-amino-1,8-naphthalimide promotes the reaction [Arsenic Trioxide results in decreased cell proliferation]] 1: Homo sapiens Hep G2 Cells
4 genes: BAX | BCL2 | PRKDC | XRCC5
1
21. 4-amino-1,8-naphthalimide apoptotic process Arsenic Trioxide 4-amino-1,8-naphthalimide promotes the reaction [Arsenic Trioxide results in increased apoptotic process] 1: Homo sapiens Hep G2 Cells
6 genes: ATM | BAX | BCL2 | CASP3 | CHEK2 | PARP1
1
22. 4-amino-1,8-naphthalimide apoptotic process Arsenic Trioxide | Lipopolysaccharides Lipopolysaccharides inhibits the reaction [4-amino-1,8-naphthalimide promotes the reaction [Arsenic Trioxide results in increased apoptotic process]] 1: Homo sapiens Hep G2 Cells
6 genes: ATM | BAX | BCL2 | CASP3 | CHEK2 | PARP1
1
23. 5-aminoisoquinolinone cell death Hydrogen Peroxide 5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased cell death] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line   1
24. 5-aminoisoquinolinone cell proliferation Hydrogen Peroxide 5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased cell proliferation] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line
4 genes: AKT1 | BAX | BCL2 | GSK3B
1
25. 5-aminoisoquinolinone reactive oxygen species biosynthetic process Hydrogen Peroxide 5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased reactive oxygen species biosynthetic process] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line   1
26. 5-aminoisoquinolinone DNA damage response, detection of DNA damage Hydrogen Peroxide 5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased DNA damage response, detection of DNA damage] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line 1 gene: PARP1 1
27. 5-aminoisoquinolinone cell death 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | Hydrogen Peroxide 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased cell death]] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line   1
28. 5-aminoisoquinolinone cell proliferation 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | Hydrogen Peroxide 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased cell proliferation]] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line
4 genes: AKT1 | BAX | BCL2 | GSK3B
1
29. 6-(3-(2-hydroxyethyl)amino-1-propyl)-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno(1,2-)isoquinoline DNA ligation 6-(3-(2-hydroxyethyl)amino-1-propyl)-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno(1,2-)isoquinoline results in decreased DNA ligation     1
30. 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide mitotic cell cycle arrest 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog results in increased mitotic cell cycle arrest 1: Homo sapiens Prostate | Cell Line, Tumor   1
31. 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide apoptotic process 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog results in increased apoptotic process 1: Homo sapiens Prostate | Cell Line, Tumor
7 genes: AKT1 | BAD | CASP3 | CASP8 | CASP9 | CDK1 | PARP1
1
32. 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide regulation of mitochondrial membrane potential 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog affects regulation of mitochondrial membrane potential 1: Homo sapiens Prostate | Cell Line, Tumor   1
33. 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide release of cytochrome c from mitochondria 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog results in increased release of cytochrome c from mitochondria 1: Homo sapiens Prostate | Cell Line, Tumor 1 gene: BAD 1
34. 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide cell proliferation Dihydrotestosterone 6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog inhibits the reaction [Dihydrotestosterone results in increased cell proliferation] 1: Homo sapiens Prostate | Cell Line, Tumor
4 genes: AKT1 | AR | BAD | CDK1
1
35. 7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide positive regulation of urine volume 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer 7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased positive regulation of urine volume] 1: Rattus norvegicus Kidney   1
36. A-1155463 apoptotic process BRAF | Vemurafenib A-1155463 promotes the reaction [[BRAF protein mutant form results in increased susceptibility to Vemurafenib] which results in increased apoptotic process] 1: Homo sapiens Skin | Cell Line, Tumor   1
37. Alcuronium histamine secretion mediated by immunoglobulin Flunitrazepam | Thiopental [Alcuronium co-treated with Flunitrazepam co-treated with Thiopental] results in increased histamine secretion mediated by immunoglobulin 1: Homo sapiens Plasma   1
38. Alcuronium histamine secretion mediated by immunoglobulin Flunitrazepam | Nalbuphine | Thiopental Nalbuphine promotes the reaction [[Alcuronium co-treated with Flunitrazepam co-treated with Thiopental] results in increased histamine secretion mediated by immunoglobulin] 1: Homo sapiens Plasma   1
39. amonafide nucleic acid phosphodiester bond hydrolysis amonafide results in increased nucleic acid phosphodiester bond hydrolysis 1: unidentified monkey Cell Line, Transformed   1
40. Apomorphine glycosylation Apomorphine results in increased glycosylation 2: Mus musculus | Rattus norvegicus Hippocampus   1
41. Apomorphine glycosylation Apomorphine results in increased glycosylation 2: Mus musculus | Rattus norvegicus Corpus Striatum   1
42. Apomorphine glycosylation Apomorphine results in increased glycosylation 2: Mus musculus | Rattus norvegicus Neocortex   1
43. Apomorphine regulation of blood pressure Apomorphine results in decreased regulation of blood pressure 1: Canis lupus familiaris Cardiovascular System 1 gene: TAC1 2
44. Apomorphine regulation of heart rate Apomorphine results in increased regulation of heart rate 1: Canis lupus familiaris Cardiovascular System 1 gene: DRD2 2
45. Apomorphine regulation of blood pressure Apomorphine affects regulation of blood pressure 1: Rattus norvegicus Cardiovascular System 1 gene: TAC1 1
46. Apomorphine apoptotic process Oxidopamine Apomorphine inhibits the reaction [Oxidopamine results in increased apoptotic process] 1: Homo sapiens Brain | Cell Line, Tumor
3 genes: AVP | CCK | CCKBR
1
47. Apomorphine apoptotic DNA fragmentation Oxidopamine Apomorphine inhibits the reaction [Oxidopamine results in increased apoptotic DNA fragmentation] 1: Homo sapiens Brain | Cell Line, Tumor   1
48. Apomorphine membrane lipid catabolic process Iron Apomorphine inhibits the reaction [Iron results in increased membrane lipid catabolic process] Microsomes   1
49. Apomorphine regulation of heart rate Apomorphine affects regulation of heart rate 1: Rattus norvegicus Heart 1 gene: DRD2 1
50. Apomorphine response to oxidative stress Apomorphine results in decreased response to oxidative stress 1: Rattus norvegicus Heart   1
1–50 of 573 results.