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Chemical Ivermectin

Name Ivermectin
CAS Type 1 Name Ivermectin
Equivalent Terms Eqvalan | Ivermectin Merck Brand | Ivomec | Mectizan | Merck Brand of Ivermectin | MK933 | MK 933 | MK-933 | Stromectol
CAS Registry Number 70288-86-7
Definition A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Structure Ivermectin
Top Interacting
Genes
MeSH® ID D007559
External Links

Top ↑ Ancestors

ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Lactones Has associated genes Has associated diseases Has associated exposure references Polyketides Has associated genes Has associated diseases Has associated exposure references Macrolides Has associated genes Has associated diseases Has associated exposure references Ivermectin Has associated genes Has associated diseases Has associated exposure references

Top ↑ Descendants

Ivermectin Has associated genes Has associated diseases Has associated exposure references
  1,19-seco-avermectin
  22,23-dihydro-13-O-((2-methoxyethoxy)methyl)abamectin B(1a) aglycone
  22,23-dihydro-13-O-((2-methoxyethoxy)-methyl)abamectin B(1b) aglycone
  22,23-dihydroavermectin B(1)a Has associated genes Has associated diseases
  22,23-dihydroavermectin B(1a)-4''-(4-((4-(ethyl(1,2,3,4-tetrahydro-1,4-dioxo-6-phthalazinyl)amino)butyl)amino)-4-oxobutanoate)
  27-hydroxyavermectin
  4''-5,7-dimethylbodipypropionylivermectin
  4'-amino-4'-avermectin B1 benzoate
  4'-deoleandrosyl-6,8a-seco-6,8a-deoxyavermectin A1a
  4'-deoleandrosyl-6,8a- seco-6,8a-deoxyavermectin B1a
  4''-epiacetylamino-4''-deoxyavermectin B1 Has associated genes Has associated diseases
  4''-epi-methylamino-4''-deoxyavermectin B1
  4''-oxo-avermectin
  6,8a-seco-6,8a-deoxyavermectin B1a aglycone
  abamectin Has associated genes Has associated diseases Has associated exposure references
  avermectin Has associated genes Has associated diseases
  avermectin B(1)a
  avermectin B2a
  avermectin H2B1b
  demethylavermectins
  desmethylamino-emamectin B1a
  doramectin Has associated genes Has associated diseases
  emamectin Has associated genes Has associated diseases
  emamectin benzoate Has associated genes Has associated diseases
  L 648548
  selamectin Has associated genes Has associated diseases
  UK 71647