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Chemical Lovastatin

Name Lovastatin
CAS Type 1 Name Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
Equivalent Terms 1 alpha-Isomer Lovastatin | 6 Methylcompactin | 6-Methylcompactin | alpha-Isomer Lovastatin, 1 | Lovastatin, 1 alpha Isomer | Lovastatin, 1 alpha-Isomer | Lovastatin, (1 alpha(S*))-Isomer | Mevacor | Mevinolin | MK803 | MK 803 | MK-803 | Monacolin K
CAS Registry Number 75330-75-5
Definition A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Structure Lovastatin
Top Interacting
Genes
MeSH® ID D008148
External Links
CCRIS
75330-75-5
ChEBI
75330-75-5
ChemIDplus®
75330-75-5
DrugBank
DB00227
Household Products Database
75330-75-5
HSDB®
75330-75-5
PubChem
D008148
TOXLINE®
Query

Top ↑ Ancestors

1. Chemicals ← Organic Chemicals Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Hydrocarbons Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Hydrocarbons, Cyclic Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Hydrocarbons, Aromatic Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Polycyclic Aromatic Hydrocarbons Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Naphthalenes Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Lovastatin Has associated genes Has associated diseases Has associated phenotype references
2. Chemicals ← Polycyclic Compounds Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Polycyclic Aromatic Hydrocarbons Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Naphthalenes Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Lovastatin Has associated genes Has associated diseases Has associated phenotype references

Top ↑ Descendants

Lovastatin Has associated genes Has associated diseases Has associated phenotype references
  6-(2-(8-((4-fluorobenzyl)oxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl)ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
  6-hydroxyisocompactin
  dihydrocompactin
  dihydromevinolin
  dihydroxy-7-(1,2,3,5,6,7,8,8a-octahydro-3,5-dihydroxy-2,6-dimethyl-8-(2-methylbutyryloxy)naphthalen-1-yl)heptanoic acid lactone
  dihydroxy-7-(1,2-dihydro-2-hydroxymethyl-6-methylnaphthalen-1-yl)heptanoic acid
  L 157012
  L 647318 Has associated diseases
  L 669262
  lovastatin-niacin combination Has associated genes Has associated diseases
  mevastatin Has associated genes Has associated diseases Has associated phenotype references
  mevinolinic acid
View node Simvastatin Has associated genes Has associated diseases Has associated phenotype references
  versicorin