Lovastatin

Name	Lovastatin
CAS Type 1 Name	Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R),3alpha,7beta,8beta(2S,4S*),8abeta))-
Equivalent Terms	1 alpha-Isomer Lovastatin \| 6 Methylcompactin \| 6-Methylcompactin \| alpha-Isomer Lovastatin, 1 \| Lovastatin, 1 alpha Isomer \| Lovastatin, 1 alpha-Isomer \| Lovastatin, (1 alpha(S*))-Isomer \| Mevacor \| Mevinolin \| MK803 \| MK 803 \| MK-803 \| Monacolin K
CAS Registry Number	75330-75-5
Definition	A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Structure
Top Interacting Genes
MeSH^® ID	D008148
External Links	CCRIS 75330-75-5 ChEBI 75330-75-5 ChemIDplus^® 75330-75-5 DrugBank DB00227 Household Products Database 75330-75-5 HSDB^® 75330-75-5 PubChem D008148 TOXLINE^® Query

Top ↑ Ancestors

1.	Chemicals ← Organic Chemicals ← Hydrocarbons ← Hydrocarbons, Cyclic ← Hydrocarbons, Aromatic ← Polycyclic Hydrocarbons, Aromatic ← Naphthalenes ← Lovastatin
2.	Chemicals ← Polycyclic Compounds ← Polycyclic Hydrocarbons, Aromatic ← Naphthalenes ← Lovastatin

Top ↑ Descendants

Lovastatin
	6-(2-(8-((4-fluorobenzyl)oxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl)ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
	6-hydroxyisocompactin
	dihydrocompactin
	dihydromevinolin
	dihydroxy-7-(1,2,3,5,6,7,8,8a-octahydro-3,5-dihydroxy-2,6-dimethyl-8-(2-methylbutyryloxy)naphthalen-1-yl)heptanoic acid lactone
	dihydroxy-7-(1,2-dihydro-2-hydroxymethyl-6-methylnaphthalen-1-yl)heptanoic acid
	L 157012
	L 647318
	L 669262
	lovastatin-niacin combination
	mevastatin
	mevinolinic acid
	Simvastatin
	versicorin