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Chemical Minerals

These are exposure studies associated with the chemical and all of its children.

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  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. von Ehrenstein OS, et al. (2016). California Cancer Registry Our data suggest that in utero and infancy exposures to air toxics generated by industrial and road traffic sources may increase the risk of primitive neuroectodermal tumor and medulloblastoma, with limited support for increased risks for astrocytoma in children up to age 6. 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 2-dichlorobenzene | 2-xylene | 4-dichlorobenzene | Acetaldehyde | Benzene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | Chloroform | Chromium | chromium hexavalent ion | ethylbenzene | Formaldehyde | indeno(1,2,3-cd)pyrene | Lead | Methylene Chloride | Nickel | Polycyclic Aromatic Hydrocarbons | Selenium | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene Controls for disease:Neuroectodermal Tumors, Primitive | Subjects with disease:Neuroectodermal Tumors, Primitive United States air 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 2-dichlorobenzene | 2-xylene | 4-dichlorobenzene | Acetaldehyde | Benzene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | Chloroform | Chromium | chromium hexavalent ion | ethylbenzene | Formaldehyde | indeno(1,2,3-cd)pyrene | Lead | Methylene Chloride | Nickel | Polycyclic Aromatic Hydrocarbons | Selenium | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene Details Astrocytoma | Medulloblastoma | Neuroectodermal Tumors, Primitive
2. Adlard B, et al. (2014). Trinational Biomonitoring Study The objective of this paper is to use statistical methods to compare the concentrations of select persistent organic pollutants and metals in the blood of primiparous women from Canada and Mexico after adjusting for covariates. 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | beta-hexachlorocyclohexane | Cadmium | Cobalt | DDT | Dichlorodiphenyl Dichloroethylene | Lead | Mercury | Nickel | nonachlor | oxychlordane | PCB 180 | pentabromodiphenyl ether | Polychlorinated Biphenyls | Selenium | Thallium | Tin Pregnant females Canada|Mexico blood | plasma 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | beta-hexachlorocyclohexane | Cadmium | Cobalt | DDT | Dichlorodiphenyl Dichloroethylene | Lead | Mercury | Nickel | nonachlor | oxychlordane | PCB 180 | pentabromodiphenyl ether | Polychlorinated Biphenyls | Selenium | Thallium | Tin Details
3. Robinson O, et al. (2015). INfancia y Medio Ambiente (INMA) Project In summary, the correlation analysis presented here of multiple environmental exposures among pregnant women provide a first picture of the structure of the exposome during the crucial in utero period. 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | 2,4,5,2',4',5'-hexachlorobiphenyl | Antimony | Arsenic | Benzene | beta-hexachlorocyclohexane | bisphenol A | Cadmium | Cesium | Chloroform | Cobalt | Copper | Cotinine | decabromobiphenyl ether | Dichlorodiphenyl Dichloroethylene | hexabrominated diphenyl ether 153 | hexabromodiphenyl ether 154 | Hexachlorobenzene | Lead | Mercury | Molybdenum | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | Nickel | Nitric Oxide | Nitrogen Dioxide | Nitrogen Oxides | Particulate Matter | PCB 180 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | Pesticides | Phthalic Acids | Selenium | Thallium | Tobacco Smoke Pollution | Trihalomethanes | Zinc Pregnant females Spain air | blood, cord | colostrum | serum | urine | water 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | 2,4,5,2',4',5'-hexachlorobiphenyl | Antimony | Arsenic | Benzene | beta-hexachlorocyclohexane | bisphenol A | Cadmium | Cesium | Chloroform | Cobalt | Copper | Cotinine | decabromobiphenyl ether | Dichlorodiphenyl Dichloroethylene | hexabrominated diphenyl ether 153 | hexabromodiphenyl ether 154 | Hexachlorobenzene | Lead | Mercury | Molybdenum | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | Nickel | Nitric Oxide | Nitrogen Dioxide | Nitrogen Oxides | Particulate Matter | PCB 180 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | Pesticides | Phthalic Acids | Selenium | Thallium | Tobacco Smoke Pollution | Trihalomethanes | Zinc Details
4. Dallaire R, et al. (2009). Exposure to several polyhalogenated compounds was associated with modifications of the thyroid parameters in adult Inuit, mainly by reducing total triiodothyronine and thyroxine-binding globulin circulating concentrations. 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Dioxins | Halogenated Diphenyl Ethers | Hexachlorobenzene | Hydrocarbons, Chlorinated | PCB 180 | Pentachlorophenol | perfluorooctane sulfonic acid | Polybrominated Biphenyls | Polychlorinated Biphenyls | Selenium Study subjects Canada blood | plasma | serum 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Dioxins | hexabrominated diphenyl ether 153 | Hexachlorobenzene | PCB 180 | Pentachlorophenol | perfluorooctane sulfonic acid | Polychlorinated Biphenyls | Selenium | SERPINA7 | Thyroxine | Triiodothyronine | TSHB Details regulation of thyroid-stimulating hormone secretion | thyroid hormone metabolic process
5. Gagnon F, et al. (2004). A survey was carried out on 162 recreational harvesters, and shellfish were sampled for chemical contaminant analysis. 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | Arsenic | benzo(e)pyrene | Cadmium | Chlordan | Chromium | Copper | DDT | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Lead | Manganese | Mercury | naphthalene | Nickel | nonachlor | Polychlorinated Biphenyls | Selenium | Zinc Workers Canada 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | Arsenic | benzo(e)pyrene | Cadmium | Chlordan | Chromium | Copper | DDT | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Lead | Manganese | Mercury | naphthalene | Nickel | nonachlor | Polychlorinated Biphenyls | Selenium | Zinc Details
6. Thurston GD, et al. (2011). Using daily fine particulate matter (PM2.5) composition data, we applied multivariate methods to identify and quantify the major fine particulate matter source components in the U.S. Air Pollutants | Particulate Matter United States air, ambient Arsenic | Calcium | Carbon | Chlorine | Copper | Iron | Lead | Magnesium | Manganese | Nickel | Nitrates | Nitrogen Dioxide | Particulate Matter | Potassium | Selenium | Silicon | Sodium | Soot | Sulfur | Vanadium | Zinc Details
7. Higuchi K, et al. (2012). This study showed that Mt. Sakurajima's volcanic activities increased the mortality of lung cancer and chronic obstructive pulmonary diseases in the Sakurajima-Tarumizu area, which has the largest amount of ashfall from the volcano in its vicinity. Air Pollutants | Silicon Dioxide Study subjects Japan Air Pollutants | Silicon Dioxide Details Death | Lung Neoplasms | Pulmonary Disease, Chronic Obstructive | Respiration Disorders
8. Morton J, et al. (2014). We report 95th percentiles of 61 elements in urine samples from occupationally unexposed UK adults. Aluminum | Antimony | Arsenic | Barium | Beryllium | Bismuth | Boron | Bromine | Cadmium | Cerium | Cesium | Chromium | Cobalt | Copper | Dysprosium | Erbium | Europium | Gadolinium | Gallium | Germanium | Gold | Hafnium | Holmium | Indium | Iridium | Lanthanum | Lead | Lithium | Lutetium | Manganese | Mercury | Molybdenum | Neodymium | Nickel | Niobium | Osmium | Palladium | Platinum | Praseodymium | Rhodium | Rubidium | Ruthenium | Samarium | Scandium | Selenium | Silver | Strontium | Tantalum | Tellurium | Terbium | Thallium | Thorium | Thulium | Tin | Titanium | Tungsten | Vanadium | Ytterbium | Yttrium | Zinc | Zirconium Study subjects United Kingdom urine Aluminum | Antimony | Arsenic | Barium | Beryllium | Bismuth | Boron | Bromine | Cadmium | Cerium | Cesium | Chromium | Cobalt | Copper | Dysprosium | Erbium | Europium | Gadolinium | Gallium | Germanium | Gold | Hafnium | Holmium | Indium | Iridium | Lanthanum | Lead | Lithium | Lutetium | Manganese | Mercury | Molybdenum | Neodymium | Nickel | Niobium | Osmium | Palladium | Platinum | Praseodymium | Rhodium | Rubidium | Ruthenium | Samarium | Scandium | Selenium | Silver | Strontium | Tantalum | Tellurium | Terbium | Thallium | Thorium | Thulium | Tin | Titanium | Tungsten | Vanadium | Ytterbium | Yttrium | Zinc | Zirconium Details
9. Le Bot B, et al. (2016). We measured 26 inorganic compounds in the tap water of representative homes of children in metropolitan France in 2008-2009. diet Aluminum | Antimony | Arsenic | Barium | Beryllium | Boron | Cadmium | Calcium | Cerium | Chromium | Cobalt | Copper | Iron | Lead | Magnesium | Manganese | Molybdenum | Nickel | Potassium | Selenium | Sodium | Strontium | Thallium | Uranium | Vanadium | Zinc Children France water, drinking Aluminum | Antimony | Arsenic | Barium | Beryllium | Boron | Cadmium | Calcium | Cerium | Chromium | Cobalt | Copper | Iron | Lead | Magnesium | Manganese | Molybdenum | Nickel | Potassium | Selenium | Sodium | Strontium | Thallium | Uranium | Vanadium | Zinc Details
10. Al-Sabbak M, et al. (2012). Our data suggested that birth defects in the Iraqi cities of Al Basrah and Fallujah are mainly folate-dependent. This knowledge offers possible treatment options and remediation plans for at-risk Iraqi populations. Aluminum | Arsenic | Cadmium | Chromium | Cobalt | Copper | Iron | Lead | Manganese | Mercury | Molybdenum | Nickel | Selenium | Thorium | Uranium | Vanadium | Zinc Children | Controls for disease:Congenital Abnormalities | Subjects with disease:Congenital Abnormalities | Study subjects Brazil|Canada|
Ethiopia|India|
Iraq|Mexico|
Norway|Pakistan|
Poland|Spain|
Turkey|United States
hair | nail | tooth Aluminum | Arsenic | Cadmium | Chromium | Cobalt | Copper | Iron | Lead | Manganese | Mercury | Molybdenum | Nickel | Selenium | Thorium | Uranium | Vanadium | Zinc Details
11. Dong Z, et al. (2015). National Health and Nutrition Examination Survey (NHANES) Cement production is a major source of metals in the environment; we measured aluminum, arsenic, cadmium, lead, mercury, and selenium in blood and hair from residents near a cement plant; smoking contributed to cadmium and lead, and seafood consumption contributed to mercury and arsenic exposures; however, the study population was not at elevated health risk, and the contribution of the cement plant to metal exposures in the community was minimal. diet | tobacco Aluminum | Arsenic | Cadmium | Lead | Mercury | Selenium Study subjects United States air, ambient | blood | hair Aluminum | Arsenic | Cadmium | Lead | Mercury | Selenium Details
12. Dai L, et al. (2016). Normative Aging Study (NAS) Our study suggested that exposure to ambient nickel was associated with increased blood pressure independent of particulate matter <=2.5 microns mass in our study population of elderly men. Aluminum | Copper | Iron | Nickel | Particulate Matter | Potassium | Selenium | Silicon | Sodium | Sulfur | Vanadium | Zinc Veterans United States Aluminum | Copper | Iron | Nickel | Particulate Matter | Potassium | Selenium | Silicon | Sodium | Sulfur | Vanadium | Zinc Details regulation of blood pressure
13. Rondeau V, et al. (2009). Aluminum Maladie d'Alzheimer (ALMA+) | Personnes Agees Quid Study (PAQUID) We found that the cognitive decline and the risk of dementia were higher for high consumption of Aluminum from drinking water. age Aluminum | Silicon Dioxide Study subjects France water, drinking, bottled | water, tap Aluminum | Silicon Dioxide Details Alzheimer Disease | cognition
14. Wu M, et al. (2010). These findings confirm the previously reported association between World Trade Center dust exposure and bronchiolar and interstitial lung disease. Aluminum Silicates | Asbestos, Serpentine | Calcium Sulfate | Magnesium Silicates | Nanotubes, Carbon Workers United States lung Aluminum Silicates | Asbestos, Serpentine | Calcium Sulfate | Magnesium Silicates | Nanotubes, Carbon Details Bronchiolitis | Fibrosis | Metaplasia | Pneumonia
15. Stamp LK, et al. (2015). We have replicated findings identifying dust exposure (grain and silica) and farm exposure as risk factors for granulomatosis with polyangiitis; we have shown activities associated with exposure to inhaled antigens (in particular those related to farming or gardening) may increase the risk of the disease. Antigens | Dust | Silicon Dioxide Controls for disease:Granulomatosis with Polyangiitis | Subjects with disease:Granulomatosis with Polyangiitis New Zealand Details Granulomatosis with Polyangiitis
16. Pang Y, et al. (2016). Multi-Ethnic Study of Atherosclerosis (MESA) | Strong Heart Study (SHS) We searched to identify patterns of metal mixtures which could suggest common environmental sources and/or metabolic pathways of different urinary metals, and compared metal-mixtures in two population-based studies from urban/sub-urban and rural/town areas in the US. race | tobacco Antimony | Arsenic | Cadmium | Lead | Molybdenum | Selenium | Tungsten | Uranium | Zinc Study subjects United States urine Antimony | Arsenicals | Cadmium | Lead | Molybdenum | Selenium | Tungsten | Uranium | Zinc Details
17. Rice DC, et al. (2010). National Health and Nutrition Examination Survey (NHANES) We measured the concentrations of a suite of metals in the blood of children 1-6 years of age, and assessed potential differences by age, season, or region of Maine; the use of convenience samples provided a cost-effective mechanism for assessing exposure of young children. Antimony | Arsenic | Cadmium | Manganese | Mercury | Selenium | Uranium Children United States blood Antimony | Arsenic | Cadmium | Manganese | Mercury | Selenium | Uranium Details
18. Li P, et al. (2012). Third National Death Cause Survey (NDCS) Occupational agents represent an important cause of cancer, but indoor radon plays a relatively limited role in cancer causes in China. Arsenic | Asbestos | Benzene | benzidine | Chromates | Coke | Radon | Silicon Dioxide Study subjects China Details Leukemia | Lung Neoplasms | Mesothelioma | Urinary Bladder Neoplasms
19. Igra AM, et al. (2016). We found that serum boron concentrations were inversely associated with birth size (length and weight), and the impact of boron appeared stronger when restricted to the third trimester, when the serum boron concentrations were the highest. Arsenic | Boron | Cadmium | Cesium | Lead | Lithium | Selenium Infants or newborns | Pregnant females Argentina blood | serum | urine | water, drinking Arsenic | Boron | Cadmium | Cesium | Lead | Lithium | Selenium Details Birth Weight | Prenatal Exposure Delayed Effects
20. Hossain MB, et al. (2012). Environmental cadmium exposure was associated with DNA hypomethylation in peripheral blood, and DNMT1 genotypes modified this association. genetics Arsenic | Boron | Cadmium | Cesium | Lithium | Selenium | Zinc Subjects with gene influence:DNMT1 | Study subjects Argentina blood | urine Arsenicals | Boron | Cadmium | Cesium | Lithium | Selenium | Zinc Details DNA methylation
21. Broberg K, et al. (2011). Exposure to lithium via drinking water and other environmental sources may affect thyroid function, consistent with known side effects of medical treatment with lithium. diet Arsenic | Boron | Cesium | Dextrothyroxine | Iodine | Lithium | Selenium Study subjects Argentina plasma | urine Arsenic | Boron | Cesium | Dextrothyroxine | Iodine | Lithium | Selenium Details
22. Veyhe AS, et al. (2015). Northern Norway Mother-and-Child Contaminant Cohort Study (MISA) The linear combinations of variables generated by principal component analysis identified prominent dietary sources of organochlorine groups and of prominent toxic elements and highlighted the importance of maternal characteristics (e.g., pregnancy histories and smoking habits). diet | tobacco Arsenic | Cadmium | Cobalt | Copper | Lead | Manganese | Mercury | Molybdenum | Polychlorinated Biphenyls | Selenium | Zinc Pregnant females Norway blood | serum 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',3,4',5,5',6-heptachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Arsenic | Cadmium | Cobalt | Copper | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Lead | Manganese | Mercury | Molybdenum | nonachlor | PCB 180 | Selenium | Zinc Details
23. Karmaus W, et al. (2008). The findings of this 2-year follow-up study indicate that metals and metalloids do not play a role in the etiology of Balkan Endemic Nephropathy. Against the assumption in the literature, selenium was not protective but a risk factor. Arsenic | Cadmium | Creatinine | Lead | Selenium Study subjects Bulgaria blood | serum | urine Arsenic | Cadmium | Creatinine | Lead | Selenium Details Balkan Nephropathy | creatinine homeostasis | gene expression
24. Thurston GD, et al. (2016). American Cancer Society Cancer Prevention Study II (ACS CPS-II) Long-term fine particulate matter (PM2.5) exposures from fossil fuel combustion, especially coal burning but also from diesel traffic, were associated with increases in ischemic heart disease mortality in this nationwide population. Arsenic | Carbon | Chlorine | Iron | Lead | Manganese | Particulate Matter | Potassium | Selenium | Silicon | Soot | Sulfur Study subjects United States air, ambient | soil Arsenic | Calcium | Carbon | Chlorine | Iron | Lead | Manganese | Nickel | Particulate Matter | Potassium | Selenium | Silicon | Sodium | Soot | Sulfur | Vanadium | Zinc Details Death | Myocardial Ischemia
25. Skröder Löveborn H, et al. (2016). Maternal and Infant Nutrition Interventions in Matlab (MINIMat) Children methylate arsenic more efficiently than their mothers. age Arsenic | Copper | Manganese | Selenium | Zinc Children | Pregnant females Bangladesh erythrocyte | urine Arsenic | Copper | Manganese | Selenium | Zinc Details cellular response to arsenic-containing substance | detoxification of arsenic-containing substance
26. George CM, et al. (2013). Health Effects of Arsenic Longitudinal Study (HEALS) Our results suggest that selenium is inversely associated with biomarkers of arsenic burden in both adults and children. Arsenic | Creatinine | Folic Acid | Selenium | Vitamin B 12 Children | Study subjects Bangladesh blood | urine | water Arsenic | Creatinine | Folic Acid | Selenium | Vitamin B 12 Details
27. Parvez F, et al. (2011). Our research demonstrates an adverse association of arsenic exposure and a protective association of selenium on motor function in children. Arsenic | Lead | Manganese | Selenium Children Bangladesh blood | nail | urine | water, well Arsenic | Creatinine | Lead | Manganese | Selenium Details
28. Duncan KE, et al. (2010). In summary, we report here that water-elutriated, small size fractions of Libby amphibole and amosite (LA2.5 and AM2.5, respectively), which presumably penetrate deeper into the lung, are at least as potent in stimulating epithelial cell production of proinflammatory cytokines as unfractionated LA and AM. Furthermore, AM2.5 induced a 4- to 10-fold greater proinflammatory response compared with LA2.5. tobacco Asbestos, Amosite | Asbestos, Amphibole Study subjects United States Asbestos, Amosite | Asbestos, Amphibole Details inflammatory response | regulation of gene expression
29. Isik R, et al. (2001). Diffuse malignant pleural mesothelioma patients with environmental asbestos exposure (vs. occupational exposure) showed more p21 (CDKN1A) immunopositivity; as well, patients with positive immunostaining had longer exposure times and were older than those having negative immunostaining. age Asbestos, Amphibole | Asbestos Subjects with disease:Mesothelioma, Malignant | Workers Turkey|United Kingdom biopsy CDKN1A Details
30. Hiraku Y, et al. (2014). We demonstrate that 8-nitroguanine formation is associated with asbestos content in human lung tissues, raising the possibility that it might serve as a biomarker to evaluate asbestos exposure and carcinogenic risk. Asbestos, Amphibole | Asbestos Controls for disease:Mesothelioma, Malignant | Subjects with disease:Mesothelioma, Malignant Japan lung 8-nitroguanine | APEX1 | Asbestos, Amphibole | Asbestos, Serpentine Details
31. Vinikoor LC, et al. (2010). Agency for Toxic Substances and Disease Registry These data suggest that residents of Libby, Montana, who were children when the mine closed experienced some respiratory symptoms associated with asbestos-contaminated vermiculite exposure. Asbestos, Amphibole | vermiculite Study subjects United States Details Respiration Disorders
32. Ferrante D, et al. (2007). Household exposure, as experienced by these asbestos-cement workers' wives, increases risk for pleural malignant mesothelioma but not for lung cancer. Asbestos Study subjects Italy Details Mesothelioma, Malignant | Pleural Neoplasms
33. Mastrangelo G, et al. (2011). Osteopontin increased with increasing age and several aspects of asbestos exposure, without differences related to the presence of pleural plaques; the explanatory variables with a significant independent influence on OPN were length of exposure (positive correlation) and time elapsed since last exposure (positive correlation); however, since asbestos in lung tissue tends to wane over time, OPN should decrease (rather than increase) with time since last exposure, and, therefore, OPN cannot be a reliable biomarker of either exposure or the presence of pleural plaques. age Asbestos Workers Italy plasma SPP1 Details
34. Rodríguez Portal JA, et al. (2009). These data attest to good diagnostic sensitivity and specificity of soluble mesothelin-related peptides for the diagnosis of malignant mesothelioma, and we also show that serum levels might serve as a marker of asbestos exposure. Asbestos Controls for disease:Mesothelioma, Malignant | Subjects with disease:Mesothelioma, Malignant | Subjects with disease:Pleural Diseases Spain serum MSLN Details Mesothelioma, Malignant
35. Christensen BC, et al. (2008). Our data suggest that patient survival is associated with asbestos fiber burden in malignant pleural mesothelioma and is perhaps modified by susceptibility. sex Asbestos Subjects with disease:Mesothelioma, Malignant United States lung Asbestos Details Death
36. Leivo-Korpela S, et al. (2012). The adipokine adipsin was associated with the degree of parenchymal fibrosis, impairment of pulmonary diffusing capacity, and with inflammatory activity in asbestos-exposed subjects, suggesting that adipsin may have a role in the pathogenesis or as a biomarker in asbestos-induced lung disease. Asbestos Controls for disease:Asbestosis | Subjects with disease:Asbestosis | Workers Finland plasma CFD Details Asbestosis | Pulmonary Fibrosis | cytokine production involved in inflammatory response | inflammatory response | interleukin-6 production
37. Filiberti R, et al. (2013). Multivariate analysis revealed significant predictors of increased soluble mesothelin-related peptide (including age greater than 57 years, current smoking, a positive anamnesis for cancer and for asbestos-related pleural lesions, and BMI less than 25); the degree of these associations is low, nevertheless they should be accounted for in the interpretation of mesothelin as a candidate marker predictive of mesothelioma. age | body mass index | disease | tobacco Asbestos Controls for disease:Neoplasms | Subjects with disease:Neoplasms | Subjects with disease:Pleural Diseases | Workers Italy serum MSLN Details
38. Andujar P, et al. (2013). These results emphasise distinct genetic alterations between asbestos-related thoracic tumours, but identify common potential susceptibility factors (i.e. single nucleotide polymorphisms in intron 7 of TP53); while genetic changes in non-small cell lung cancer are dominated by the effects of tobacco smoke, the increase of transversions in TP53 gene is consistent with a synergistic effect of asbestos. Asbestos Subjects with disease:Carcinoma, Non-Small-Cell Lung France lung Asbestos | TP53 Details
39. Maule MM, et al. (2007). This study provides strong evidence that asbestos pollution from an industrial source greatly increases mesothelioma risk. Asbestos Subjects with disease:Mesothelioma Italy Details Mesothelioma
40. Kukkonen MK, et al. (2014). Our results support the hypothesis that the inflammasome is important in the development of fibrotic lung disease by associating the NLRP3 rs35829419 variant allele with increased risk of asbestos-related interstitial lung fibrosis, and the TGFB1 rs2241718 variant allele with decreased risk of asbestos-related visceral pleural fibrosis; polymorphisms in CARD8 and TIMP2 are proposed to modify the development and/or calcification of pleural thickenings. genetics Asbestos Subjects with gene influence:CARD8 | Subjects with gene influence:NLRP3 | Subjects with gene influence:TGFB1 | Subjects with gene influence:TIMP2 | Workers Finland Details Asbestosis | Calcinosis | Fibrosis | Occupational Diseases | Pleural Diseases
41. Comar M, et al. (2014). This study shows that in subjects from an hyperendemic area for malignant mesothelioma, the chemokine RANTES (CCL5) is associated with the exposure to asbestos fibres. Asbestos Controls for disease:Mesothelioma, Malignant | Subjects with disease:Mesothelioma, Malignant | Workers Italy serum CCL11 | CCL27 | CCL3 | CCL5 | CCL7 | CLEC11A | CSF1 | CSF3 | CXCL10 | CXCL12 | CXCL1 | CXCL8 | CXCL9 | HGF | IFNA2 | IFNG | IL12B | IL17A | IL1A | IL2RA | IL3 | IL4 | IL6 | LTA | MIF | NGF Details positive regulation of chemokine (C-C motif) ligand 5 production
42. Clemente M, et al. (2015). Participants affected by asbestos poisoning showed high occurrence rates of psychological health variables such as somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism, and global severity index. Asbestos Workers Spain Details Anxiety Disorders | Depressive Disorder | Obsessive-Compulsive Disorder | Paranoid Disorders | Phobic Disorders | Psychotic Disorders | Somatoform Disorders
43. Xu J, et al. (2015). The purpose of the present study was to determine whether the levels or detection rate of chemokine (C-C motif) ligand 3 (CCL3) in the serum are elevated in persons exposed to asbestos. Asbestos Study subjects Japan Details gene expression
44. Pass HI, et al. (2005). Serum osteopontin levels can be used to distinguish persons with exposure to asbestos who do not have cancer from those with exposure to asbestos who have pleural mesothelioma. Asbestos Controls for disease:Asbestosis | Subjects with disease:Asbestosis | Controls for disease:Mesothelioma | Subjects with disease:Mesothelioma | Controls for disease:Pleural Neoplasms | Subjects with disease:Pleural Neoplasms | Study subjects | Workers United States serum SPP1 Details Asbestosis | Mesothelioma | Pleural Neoplasms
45. Gilham C, et al. (2016). Our results confirm the major contribution of amosite to UK mesothelioma incidence and the substantial contribution of non-occupational exposure, particularly in women. sex Asbestos Subjects with disease:Mesothelioma, Malignant | Workers United Kingdom lung Asbestos, Amosite | Asbestos, Amphibole | Asbestos, Crocidolite | Asbestos, Serpentine Details Mesothelioma, Malignant | Pleural Neoplasms
46. Berry G, et al. (2004). The excess relative risk of lung cancer from asbestos exposure is about three times higher in non-smokers than in smokers. tobacco Asbestos Study subjects Canada|China|
Italy|Norway|
United Kingdom|United States
Details Lung Neoplasms
47. Yan L, et al. (2002). Both exposure to asbestos and GSTM1 deficiency were related to lipid peroxidation (malondialdehyde levels) in workers, but the role of the former may be more important than that of the latter. genetics Asbestos Subjects with gene influence:GSTM1 | Workers China plasma Malondialdehyde Details
48. Yoshida R, et al. (2001). We show that 8-oxodG levels in asbestos-exposed construction workers were higher (although not statistically significant), and that levels tended to correlate with duration of suspected exposure; these results suggest that even low-level asbestos exposure may induce oxidative stress. Asbestos Workers Japan urine 8-oxo-7-hydrodeoxyguanosine Details cellular response to oxidative stress
49. Paris C, et al. (2017). Asbestos-Related Diseases Cohort (ARDCo) | Asbestos-Related Diseases Cohort (ARDCo-Nut) Our findings provide support for an association between occupational exposure to asbestos and colon cancer incidence in men. Asbestos Study subjects France Details Colonic Neoplasms
50. Alavanja MC, et al. (2004). Agricultural Health Study (AHS) We also found that four heavily used agricultural pesticides, including two herbicides (i.e., metolachlor and pendimethalin) and two insecticides (i.e., chlorpyrifos and diazinon), were associated with a significant excess lung cancer risk in the Agricultural Health Study cohort. Asbestos | Carbofuran | Chlorpyrifos | Diazinon | Dicamba | Dieldrin | Lead | metolachlor | pendimethalin | Tobacco Smoke Pollution Study subjects | Workers United States Details Agricultural Workers' Diseases | Lung Neoplasms
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