1. |
Desogestrel
|
regulation of blood pressure
|
Ethinyl Estradiol
|
[Ethinyl Estradiol co-treated with Desogestrel] affects regulation of blood pressure |
1: Homo sapiens |
Cardiovascular System |
|
1 |
2. |
Desogestrel
|
spermatogenesis
|
testosterone enanthate
|
[Desogestrel co-treated with testosterone enanthate] results in decreased spermatogenesis |
1: Homo sapiens |
|
5 genes: INSL3 | LHB | SYCP1 | TAF4B | TEX19
|
1 |
3. |
Desogestrel
|
spermatogenesis
|
cetrorelix
| testosterone enanthate
|
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased spermatogenesis |
1: Homo sapiens |
Semen |
5 genes: INSL3 | LHB | SYCP1 | TAF4B | TEX19
|
1 |
4. |
Desogestrel
|
spermatogenesis
|
Testosterone
|
[Desogestrel co-treated with Testosterone] results in decreased spermatogenesis |
1: Homo sapiens |
Testis |
5 genes: INSL3 | LHB | SYCP1 | TAF4B | TEX19
|
1 |
5. |
Ethinyl Estradiol-Norgestrel Combination
|
regulation of blood pressure
|
|
Ethinyl Estradiol-Norgestrel Combination results in increased regulation of blood pressure |
1: Rattus norvegicus |
Cardiovascular System |
1 gene: NOS3
|
1 |
6. |
Ethinyl Estradiol-Norgestrel Combination
|
regulation of organ growth
|
|
Ethinyl Estradiol-Norgestrel Combination results in increased regulation of organ growth |
1: Rattus norvegicus |
Heart |
|
1 |
7. |
Ethinyl Estradiol-Norgestrel Combination
|
regulation of blood pressure
|
Indomethacin
|
Indomethacin inhibits the reaction [Ethinyl Estradiol-Norgestrel Combination results in increased regulation of blood pressure] |
1: Rattus norvegicus |
Cardiovascular System |
1 gene: NOS3
|
1 |
8. |
etonogestrel
|
spermatogenesis
|
testosterone decanoate
|
[testosterone decanoate co-treated with etonogestrel] results in decreased spermatogenesis |
1: Homo sapiens |
Semen |
|
1 |
9. |
etonogestrel
|
spermatogenesis
|
testosterone undecanoate
|
[testosterone undecanoate co-treated with etonogestrel] results in decreased spermatogenesis |
1: Homo sapiens |
Testis |
|
1 |
10. |
etonogestrel
|
spermatogenesis
|
Testosterone
|
[etonogestrel co-treated with Testosterone] results in decreased spermatogenesis |
1: Homo sapiens |
Testis |
|
1 |
11. |
Levonorgestrel
|
spermatogenesis
|
testosterone enanthate
|
[Levonorgestrel co-treated with testosterone enanthate] results in decreased spermatogenesis |
1: Homo sapiens |
|
11 genes: APOB | AR | CDC25C | FKBP6 | FSHB | INSL3 | INSL6 | LHB | ODF3 | RLN1 | SERPINA5
|
1 |
12. |
Levonorgestrel
|
spermatogenesis
|
testosterone undecanoate
|
[testosterone undecanoate co-treated with Levonorgestrel] results in decreased spermatogenesis |
1: Homo sapiens |
Testis |
11 genes: APOB | AR | CDC25C | FKBP6 | FSHB | INSL3 | INSL6 | LHB | ODF3 | RLN1 | SERPINA5
|
2 |
13. |
Levonorgestrel
|
spermatogenesis
|
testosterone enanthate
|
[testosterone enanthate co-treated with Levonorgestrel] results in decreased spermatogenesis |
1: Homo sapiens |
Testis |
11 genes: APOB | AR | CDC25C | FKBP6 | FSHB | INSL3 | INSL6 | LHB | ODF3 | RLN1 | SERPINA5
|
1 |
14. |
Levonorgestrel
|
spermatogenesis
|
testosterone enanthate
|
Levonorgestrel promotes the reaction [testosterone enanthate results in decreased spermatogenesis] |
1: Homo sapiens |
Testis |
11 genes: APOB | AR | CDC25C | FKBP6 | FSHB | INSL3 | INSL6 | LHB | ODF3 | RLN1 | SERPINA5
|
1 |
15. |
Levonorgestrel
|
spermatogenesis
|
Testosterone
|
[Levonorgestrel co-treated with Testosterone] results in decreased spermatogenesis |
1: Homo sapiens |
Testis |
11 genes: APOB | AR | CDC25C | FKBP6 | FSHB | INSL3 | INSL6 | LHB | ODF3 | RLN1 | SERPINA5
|
1 |
16. |
Norethandrolone
|
cell death
|
|
Norethandrolone results in increased cell death |
1: Rattus norvegicus |
Cell Line |
|
1 |
17. |
Norethindrone
|
DNA catabolic process
|
|
Norethindrone results in increased DNA catabolic process |
1: Homo sapiens |
Cell Line, Tumor |
|
1 |
18. |
Norethindrone
|
cell proliferation
|
|
Norethindrone results in increased cell proliferation |
1: Homo sapiens |
Cell Line, Tumor |
3 genes: AR | TP53 | VEGFA
|
1 |
19. |
Norethindrone
|
cell differentiation
|
|
Norethindrone results in increased cell differentiation |
1: Homo sapiens |
Cell Line, Tumor |
2 genes: TP53 | VEGFA
|
1 |
20. |
Norethindrone
|
mitotic cell cycle
|
|
Norethindrone results in decreased mitotic cell cycle |
1: Homo sapiens |
Breast | Cell Line, Tumor |
|
1 |
21. |
Norethindrone
|
spermatogenesis
|
Testosterone
|
[Norethindrone results in decreased abundance of Testosterone] which results in decreased spermatogenesis |
1: Macaca radiata |
Testis |
4 genes: AR | H2AFX | LHB | TP53
|
1 |
22. |
Norethindrone
|
apoptotic process
|
|
Norethindrone results in increased apoptotic process |
1: Macaca radiata |
Testis | Spermatozoa |
2 genes: MAPT | TP53
|
1 |
23. |
Norethindrone
|
spermatogenesis
|
Testosterone
|
[Norethindrone co-treated with Testosterone] results in decreased spermatogenesis |
1: Homo sapiens |
Testis |
4 genes: AR | H2AFX | LHB | TP53
|
1 |
24. |
Norethindrone
|
cell death
|
Tretinoin
|
[Norethindrone co-treated with Tretinoin] results in increased cell death |
1: Homo sapiens |
Lung | Cell Line, Tumor |
|
1 |
25. |
Norethindrone
|
positive regulation of lipid storage
|
1-Methyl-3-isobutylxanthine
| Dexamethasone
| INS
| Rosiglitazone
|
Norethindrone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased positive regulation of lipid storage] |
1: Homo sapiens |
Subcutaneous Fat | Stem Cells | Cells, Cultured |
|
1 |
26. |
Norethindrone
|
positive regulation of lipid storage
|
1-Methyl-3-isobutylxanthine
| INS
| Rosiglitazone
|
[Norethindrone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased positive regulation of lipid storage |
1: Homo sapiens |
Subcutaneous Fat | Stem Cells | Cells, Cultured |
|
1 |
27. |
Norethindrone
|
negative regulation of fat cell differentiation
|
1-Methyl-3-isobutylxanthine
| INS
| Rosiglitazone
|
[Norethindrone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased negative regulation of fat cell differentiation |
1: Homo sapiens |
Subcutaneous Fat | Stem Cells | Cells, Cultured |
2 genes: ADIPOQ | VEGFA
|
1 |
28. |
Norethindrone
|
positive regulation of intracellular estrogen receptor signaling pathway
|
|
Norethindrone results in increased positive regulation of intracellular estrogen receptor signaling pathway |
|
|
1 gene: AR
|
1 |
29. |
Norethindrone
|
positive regulation of intracellular estrogen receptor signaling pathway
|
|
Norethindrone results in increased positive regulation of intracellular estrogen receptor signaling pathway |
1: Rodentia |
Uterus |
1 gene: AR
|
1 |
30. |
norethindrone-4 beta,5 beta-epoxide
|
cell death
|
|
norethindrone-4 beta,5 beta-epoxide results in increased cell death |
1: Rattus norvegicus |
Cell Line |
|
1 |
31. |
norethindrone-4 beta,5 beta-epoxide
|
cell death
|
|
norethindrone-4 beta,5 beta-epoxide results in increased cell death |
1: Rattus norvegicus |
Hepatocytes |
|
1 |
32. |
Norethindrone Acetate
|
cell proliferation
|
Estradiol
|
[Estradiol co-treated with Norethindrone Acetate] results in increased cell proliferation |
1: Homo sapiens |
Mammary Glands, Human | Stromal Cells |
1 gene: AR
|
1 |
33. |
Norethindrone Acetate
|
cell proliferation
|
Estradiol
|
[Estradiol co-treated with Norethindrone Acetate] results in increased cell proliferation |
1: Homo sapiens |
Mammary Glands, Human | Epithelial Cells |
1 gene: AR
|
1 |
34. |
Norethindrone Acetate
|
cell proliferation
|
Estradiol
| Testosterone
|
Testosterone inhibits the reaction [[Norethindrone Acetate co-treated with Estradiol] results in increased cell proliferation] |
1: Homo sapiens |
Mammary Glands, Human | Stromal Cells |
1 gene: AR
|
1 |
35. |
Norethindrone Acetate
|
cell proliferation
|
Estradiol
| Testosterone
|
Testosterone inhibits the reaction [[Norethindrone Acetate co-treated with Estradiol] results in increased cell proliferation] |
1: Homo sapiens |
Mammary Glands, Human | Epithelial Cells |
1 gene: AR
|
1 |
36. |
Norethynodrel
|
cell death
|
|
Norethynodrel results in increased cell death |
1: Rattus norvegicus |
Cell Line |
|
1 |
37. |
Norethynodrel
|
cell proliferation
|
|
Norethynodrel results in increased cell proliferation |
1: Homo sapiens |
MCF-7 Cells |
1 gene: AR
|
1 |
38. |
Norethynodrel
|
cell proliferation
|
Fulvestrant
|
Fulvestrant inhibits the reaction [Norethynodrel results in increased cell proliferation] |
1: Homo sapiens |
MCF-7 Cells |
1 gene: AR
|
1 |
39. |
Norethynodrel
|
xenobiotic metabolic process
|
Aroclors
| ESR1
|
[Aroclors results in increased xenobiotic metabolic process] promotes the reaction [Norethynodrel binds to and results in increased activity of ESR1 protein] |
1: Homo sapiens |
Bone and Bones | Cell Line, Tumor |
|
1 |
40. |
Norethynodrel
|
xenobiotic metabolic process
|
Aroclors
| ESR1
| Glutathione
| Phosphoadenosine Phosphosulfate
| Uridine Diphosphate Glucuronic Acid
|
[[Aroclors co-treated with Glutathione co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] results in increased xenobiotic metabolic process] inhibits the reaction [Aroclors promotes the reaction [Norethynodrel binds to and results in increased activity of ESR1 protein]] |
1: Homo sapiens |
Bone and Bones | Cell Line, Tumor |
|
1 |
41. |
Norgestrel
|
mitotic cell cycle
|
|
Norgestrel results in decreased mitotic cell cycle |
1: Homo sapiens |
Breast | Cell Line, Tumor |
|
1 |
42. |
Norgestrel
|
positive regulation of lipid storage
|
1-Methyl-3-isobutylxanthine
| Dexamethasone
| INS
| Rosiglitazone
|
Norgestrel inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased positive regulation of lipid storage] |
1: Homo sapiens |
Subcutaneous Fat | Stem Cells | Cells, Cultured |
|
1 |
43. |
Norgestrel
|
negative regulation of fat cell differentiation
|
1-Methyl-3-isobutylxanthine
| INS
| Rosiglitazone
|
[Norgestrel co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased negative regulation of fat cell differentiation |
1: Homo sapiens |
Subcutaneous Fat | Stem Cells | Cells, Cultured |
1 gene: ADIPOQ
|
1 |