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Chemical Oxazoles

1–50 of 401 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 10074-G5 mitotic cell cycle arrest 10074-G5 analog results in increased mitotic cell cycle arrest 1: Homo sapiens HL-60 Cells   1
2. 10074-G5 myeloid cell differentiation 10074-G5 results in increased myeloid cell differentiation 1: Homo sapiens HL-60 Cells   1
3. 10074-G5 myeloid cell differentiation 10074-G5 analog results in increased myeloid cell differentiation 1: Homo sapiens HL-60 Cells   1
4. 10074-G5 ATP biosynthetic process 10074-G5 results in decreased ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
5. 10074-G5 ATP biosynthetic process 10074-G5 analog results in decreased ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
6. 10074-G5 cellular lipid biosynthetic process 10074-G5 analog results in increased cellular lipid biosynthetic process 1: Homo sapiens Lung | Cell Line, Tumor   1
7. 10074-G5 cellular lipid biosynthetic process 10074-G5 results in increased cellular lipid biosynthetic process 1: Homo sapiens Lung | Cell Line, Tumor   1
8. 10074-G5 ATP biosynthetic process 10074-G5 results in decreased ATP biosynthetic process 1: Homo sapiens Lung | Cell Line, Tumor   1
9. 10074-G5 ATP biosynthetic process 10074-G5 analog results in decreased ATP biosynthetic process 1: Homo sapiens Lung | Cell Line, Tumor   1
10. 10074-G5 cellular lipid biosynthetic process 10074-G5 results in increased cellular lipid biosynthetic process 1: Homo sapiens HL-60 Cells   1
11. 1,3,4-oxadiazole cell proliferation 1,3,4-oxadiazole analog results in decreased cell proliferation 1: Homo sapiens HeLa Cells   1
12. 1,3,4-oxadiazole cell proliferation 1,3,4-oxadiazole analog results in decreased cell proliferation 1: Homo sapiens MCF-7 Cells   1
13. 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Oxygen 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] 1: Homo sapiens HCT116 Cells 1 gene: HIF1A 1
14. 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine positive regulation of mitochondrial electron transport, NADH to ubiquinone 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased positive regulation of mitochondrial electron transport, NADH to ubiquinone 1: Homo sapiens Prostate | Cell Line, Tumor | Mitochondria   1
15. 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine positive regulation of oxidative phosphorylation 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased positive regulation of oxidative phosphorylation 1: Homo sapiens Lung | Cell Line, Tumor   1
16. 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine positive regulation of oxidative phosphorylation Succinic Acid Succinic Acid inhibits the reaction [1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine results in decreased positive regulation of oxidative phosphorylation] 1: Homo sapiens Lung | Cell Line, Tumor   1
17. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasodilation Glutathione Disulfide 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Glutathione Disulfide results in increased vasodilation] 1: Rattus norvegicus Heart
2 genes: SOD2 | TNF
1
18. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one ion transport S-Nitroso-N-Acetylpenicillamine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased ion transport] 1: Rattus norvegicus Urinary Bladder | Neurons, Afferent | Cells, Cultured   1
19. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one apoptotic process 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased apoptotic process 1: Rattus norvegicus Motor Neurons | Cells, Cultured
10 genes: APP | BAX | BNIP3 | CASP3 | CASP8 | HMOX1 | IFNG | TNF | TP53 | XIAP
1
20. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one apoptotic process 8-bromocyclic GMP 8-bromocyclic GMP inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased apoptotic process] 1: Rattus norvegicus Motor Neurons | Cells, Cultured
10 genes: APP | BAX | BNIP3 | CASP3 | CASP8 | HMOX1 | IFNG | TNF | TP53 | XIAP
1
21. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one apoptotic process 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased apoptotic process] 1: Rattus norvegicus Motor Neurons | Cells, Cultured
10 genes: APP | BAX | BNIP3 | CASP3 | CASP8 | HMOX1 | IFNG | TNF | TP53 | XIAP
1
22. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one apoptotic process FK 409 | Nitric Oxide 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[FK 409 results in increased abundance of Nitric Oxide] which results in increased apoptotic process] 1: Rattus norvegicus Aorta | Endothelial Cells | Cells, Cultured
10 genes: APP | BAX | BNIP3 | CASP3 | CASP8 | HMOX1 | IFNG | TNF | TP53 | XIAP
1
23. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one apoptotic DNA fragmentation S-Nitroso-N-Acetylpenicillamine | TNF 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine inhibits the reaction [TNF protein results in increased apoptotic DNA fragmentation]] U937 Cells 1 gene: CASP3 1
24. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one apoptotic process S-Nitroso-N-Acetylpenicillamine | TNF 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine inhibits the reaction [TNF protein results in increased apoptotic process]] U937 Cells
10 genes: APP | BAX | BNIP3 | CASP3 | CASP8 | HMOX1 | IFNG | TNF | TP53 | XIAP
1
25. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one chemical synaptic transmission Nitric Oxide | Nitroprusside 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased chemical synaptic transmission] 1: Rattus norvegicus Superior Cervical Ganglion   1
26. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one chemical synaptic transmission Nitric Oxide | S-Nitrosoglutathione 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased chemical synaptic transmission] 1: Rattus norvegicus Superior Cervical Ganglion   1
27. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasoconstriction 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid | Telmisartan 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Telmisartan inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased vasoconstriction]] 1: Mus musculus Mesenteric Arteries   1
28. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasoconstriction Nitric Oxide | Phenylephrine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitric Oxide inhibits the reaction [Phenylephrine results in increased vasoconstriction]] 1: Rattus norvegicus Mesenteric Arteries   1
29. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasoconstriction Charybdotoxin | Nitric Oxide | Phenylephrine [Charybdotoxin co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] inhibits the reaction [Nitric Oxide inhibits the reaction [Phenylephrine results in increased vasoconstriction]] 1: Rattus norvegicus Mesenteric Arteries   1
30. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one regulation of membrane potential Charybdotoxin | Nitric Oxide | Phenylephrine [Charybdotoxin co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] inhibits the reaction [Nitric Oxide inhibits the reaction [Phenylephrine results in increased regulation of membrane potential]] 1: Rattus norvegicus Mesenteric Arteries | Muscle, Smooth, Vascular   1
31. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasoconstriction Charybdotoxin | linsidomine | Phenylephrine [Charybdotoxin co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] inhibits the reaction [linsidomine inhibits the reaction [Phenylephrine results in increased vasoconstriction]] 1: Rattus norvegicus Mesenteric Arteries   1
32. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasoconstriction 4-Aminopyridine | linsidomine | Phenylephrine [4-Aminopyridine co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] inhibits the reaction [linsidomine inhibits the reaction [Phenylephrine results in increased vasoconstriction]] 1: Rattus norvegicus Mesenteric Arteries   1
33. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasoconstriction 4-Aminopyridine | iberiotoxin | linsidomine | Phenylephrine [[4-Aminopyridine co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] co-treated with iberiotoxin] inhibits the reaction [linsidomine inhibits the reaction [Phenylephrine results in increased vasoconstriction]] 1: Rattus norvegicus Mesenteric Arteries   1
34. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one mitochondrion organization S-nitro-N-acetylpenicillamine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased mitochondrion organization] 1: Homo sapiens Hep G2 Cells
5 genes: GABPA | NRF1 | PPARGC1A | SOD2 | TFAM
1
35. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one positive regulation of vasoconstriction Carbon Monoxide | Phenylephrine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide inhibits the reaction [Phenylephrine affects positive regulation of vasoconstriction]] 1: Rattus norvegicus Aorta, Thoracic   1
36. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one mitochondrion organization Nebivolol 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nebivolol results in increased mitochondrion organization] 1: Mus musculus 3T3-L1 Cells
5 genes: GABPA | NRF1 | PPARGC1A | SOD2 | TFAM
1
37. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Estradiol | Hemin | Nicotine | Phenylephrine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Hemin inhibits the reaction [[Nicotine co-treated with Estradiol] promotes the reaction [Phenylephrine results in increased negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure]]] 1: Rattus norvegicus Cardiovascular System   1
38. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasodilation 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid | Nitroglycerin 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in decreased vasodilation]] 2: Bos taurus | Sus scrofa Coronary Vessels
2 genes: SOD2 | TNF
1
39. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasodilation Norepinephrine | Sodium Nitrite 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Sodium Nitrite inhibits the reaction [Norepinephrine results in decreased vasodilation]] 1: Mus musculus Kidney | Arteries
2 genes: SOD2 | TNF
1
40. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one vasodilation 1,1-diethyl-2-hydroxy-2-nitrosohydrazine | Norepinephrine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [1,1-diethyl-2-hydroxy-2-nitrosohydrazine inhibits the reaction [Norepinephrine results in decreased vasodilation]] 1: Mus musculus Kidney | Arteries
2 genes: SOD2 | TNF
1
41. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one cGMP metabolic process 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects cGMP metabolic process 1: Rattus norvegicus Embryo, Mammalian | Muscle, Smooth, Vascular | Cell Line   1
42. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one cGMP metabolic process Cyclic GMP [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects cGMP metabolic process] which results in decreased abundance of Cyclic GMP 1: Rattus norvegicus Embryo, Mammalian | Muscle, Smooth, Vascular | Cell Line   1
43. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one cGMP metabolic process S-Nitroso-N-Acetylpenicillamine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine affects cGMP metabolic process] 1: Rattus norvegicus Embryo, Mammalian | Muscle, Smooth, Vascular | Cell Line   1
44. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one cGMP metabolic process Cyclic GMP | S-Nitroso-N-Acetylpenicillamine 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[S-Nitroso-N-Acetylpenicillamine affects cGMP metabolic process] which results in increased abundance of Cyclic GMP] 1: Rattus norvegicus Embryo, Mammalian | Muscle, Smooth, Vascular | Cell Line   1
45. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one cGMP metabolic process Peroxynitrous Acid 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Peroxynitrous Acid affects cGMP metabolic process] 1: Rattus norvegicus Embryo, Mammalian | Aorta, Thoracic | Muscle, Smooth, Vascular | Cell Line   1
46. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one cGMP metabolic process Cyclic GMP | Peroxynitrous Acid 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[Peroxynitrous Acid affects cGMP metabolic process] which results in increased abundance of Cyclic GMP] 1: Rattus norvegicus Embryo, Mammalian | Aorta, Thoracic | Muscle, Smooth, Vascular | Cell Line   1
47. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one positive regulation of guanylate cyclase activity BAY 58-2667 [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased positive regulation of guanylate cyclase activity 1: Sus scrofa Endothelial Cells | Cells, Cultured 1 gene: GUCA1A 1
48. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one positive regulation of guanylate cyclase activity 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased positive regulation of guanylate cyclase activity 1: Sus scrofa Endothelial Cells | Cells, Cultured 1 gene: GUCA1A 1
49. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one positive regulation of guanylate cyclase activity 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased positive regulation of guanylate cyclase activity 1: Cricetulus griseus CHO Cells 1 gene: GUCA1A 1
50. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one heme oxidation 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased heme oxidation 2: Cricetulus griseus | Rattus norvegicus CHO Cells 1 gene: HMOX1 1
1–50 of 401 results.