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Chemical Piperidines

1–50 of 1,347 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea cell proliferation Diazepam | tetramethylenedisulfotetramine [Diazepam co-treated with 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea] promotes the reaction [tetramethylenedisulfotetramine results in increased cell proliferation] 1: Mus musculus Hippocampus | Astrocytes
2 genes: AKT1 | CYP1A1
1
2. 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea cellular response to food Dietary Fats 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased cellular response to food] 1: Mus musculus Liver | Endoplasmic Reticulum   1
3. 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea microglial cell activation Diazepam | tetramethylenedisulfotetramine [Diazepam co-treated with 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea] inhibits the reaction [tetramethylenedisulfotetramine results in increased microglial cell activation] 1: Mus musculus Hippocampus | Microglia   1
4. 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea cellular response to food Dietary Fats 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased cellular response to food] 1: Mus musculus Adipose Tissue | Endoplasmic Reticulum   1
5. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of inflammatory response Lipopolysaccharides | notoginsenoside R1 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased positive regulation of inflammatory response]] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line 1 gene: TNF 1
6. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of blood vessel diameter amurensin G | ESR1 [1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole binds to and results in decreased activity of ESR1 protein] inhibits the reaction [amurensin G affects positive regulation of blood vessel diameter] 1: Rattus norvegicus Aorta, Thoracic 1 gene: NOS3 1
7. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of nitric oxide biosynthetic process amurensin G | ESR1 [1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole binds to and results in decreased activity of ESR1 protein] inhibits the reaction [amurensin G affects positive regulation of nitric oxide biosynthetic process] 1: Homo sapiens Urinary Bladder | Cell Line, Tumor
6 genes: ESR1 | IL1B | IL6 | PRL | SOD2 | TNF
1
8. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of apoptotic process Lipopolysaccharides | notoginsenoside R1 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased positive regulation of apoptotic process]] 1: Rattus norvegicus Myocytes, Cardiac | Cell Line
7 genes: IL1B | IL6 | NCOA1 | NOS3 | RELA | TGFB1 | TNF
1
9. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of centrosome duplication bisphenol A 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [bisphenol A analog results in increased positive regulation of centrosome duplication] 1: Homo sapiens Prostate | Cell Line, Tumor   1
10. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of centrosome duplication bis(4-hydroxyphenyl)sulfone 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased positive regulation of centrosome duplication] 1: Homo sapiens Prostate | Cell Line, Tumor   1
11. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of cell proliferation Estradiol 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol results in increased positive regulation of cell proliferation] 1: Homo sapiens MCF-7 Cells
9 genes: ARNT2 | FSHB | IL1B | IL6 | MAPK1 | PRL | RELA | TGFB1 | TNF
1
12. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of cell proliferation Aflatoxin B1 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Aflatoxin B1 results in decreased positive regulation of cell proliferation] 1: Homo sapiens MCF-7 Cells
9 genes: ARNT2 | FSHB | IL1B | IL6 | MAPK1 | PRL | RELA | TGFB1 | TNF
1
13. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of centrosome duplication bisphenol A 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [bisphenol A results in increased positive regulation of centrosome duplication] 1: Homo sapiens Prostate | Cell Line, Tumor   1
14. 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole positive regulation of cell proliferation Zearalenone 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Zearalenone results in increased positive regulation of cell proliferation] 1: Homo sapiens MCF-7 Cells
9 genes: ARNT2 | FSHB | IL1B | IL6 | MAPK1 | PRL | RELA | TGFB1 | TNF
1
15. 1-(gamma-chloropropyl)-2-chloromethylpiperidine cell death Reserpine Reserpine promotes the reaction [1-(gamma-chloropropyl)-2-chloromethylpiperidine results in increased cell death] 1: Rattus norvegicus Liver | Cell Line, Tumor   1
16. 1-(gamma-chloropropyl)-2-chloromethylpiperidine cell death 1-(gamma-chloropropyl)-2-chloromethylpiperidine results in increased cell death 1: Rattus norvegicus Liver | Cell Line, Tumor   1
17. 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea response to endoplasmic reticulum stress Carbon Tetrachloride 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased response to endoplasmic reticulum stress] 1: Mus musculus Liver
8 genes: ATF4 | DDIT3 | EIF2AK3 | EIF2S1 | ERN1 | HSPA5 | THBS1 | XBP1
1
18. 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone apoptotic process arsenic trioxide | phytosphingosine 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased apoptotic process] 1: Homo sapiens U937 Cells
6 genes: AIFM1 | BAX | CASP3 | CASP9 | MAPK14 | PARP1
1
19. 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone regulation of mitochondrial membrane potential arsenic trioxide | phytosphingosine 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in decreased regulation of mitochondrial membrane potential] 1: Homo sapiens U937 Cells 1 gene: BAX 1
20. 3,5-bis(2-fluorobenzylidene)piperidin-4-one stress fiber assembly HMGA2 HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased stress fiber assembly] 1: Homo sapiens Skin | Cell Line, Tumor
2 genes: RHOA | SRC
1
21. 3,5-bis(2-fluorobenzylidene)piperidin-4-one positive regulation of interleukin-8 secretion Lipopolysaccharides 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Lipopolysaccharides affects positive regulation of interleukin-8 secretion] 1: Homo sapiens Granulocytes | Cells, Cultured
3 genes: F2R | TLR1 | TLR2
1
22. 3,5-bis(2-fluorobenzylidene)piperidin-4-one negative regulation of NF-kappaB transcription factor activity 3,5-bis(2-fluorobenzylidene)piperidin-4-one affects negative regulation of NF-kappaB transcription factor activity 1: Homo sapiens MCF-7 Cells
4 genes: IRAK1 | IRAK2 | NFKBIA | NLRP12
1
23. 3,5-bis(2-fluorobenzylidene)piperidin-4-one positive regulation of NIK/NF-kappaB signaling Oxygen 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency affects positive regulation of NIK/NF-kappaB signaling] 1: Homo sapiens MCF-7 Cells
9 genes: IL12B | MYD88 | NLRP12 | NOD1 | RELA | RHOA | TLR2 | TNF | TNFSF14
1
24. 3,5-bis(2-fluorobenzylidene)piperidin-4-one focal adhesion assembly MIR33B MIR33B mRNA affects the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased focal adhesion assembly] 1: Homo sapiens Skin | Cell Line, Tumor   1
25. 3,5-bis(2-fluorobenzylidene)piperidin-4-one wound healing 3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased wound healing 1: Homo sapiens Skin | Cell Line, Tumor
2 genes: AQP1 | MAP3K1
1
26. 3,5-bis(2-fluorobenzylidene)piperidin-4-one positive regulation of cell death Oxygen [3,5-bis(2-fluorobenzylidene)piperidin-4-one co-treated with Oxygen deficiency] affects positive regulation of cell death 1: Homo sapiens MCF-7 Cells
2 genes: NOD1 | RIPK1
1
27. 3,5-bis(2-fluorobenzylidene)piperidin-4-one cellular response to hypoxia Oxygen 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency affects cellular response to hypoxia] 1: Homo sapiens MCF-7 Cells
8 genes: AKT1 | AQP1 | BCL2L1 | CFLAR | HIF1A | HMOX1 | IRAK1 | SRC
1
28. 3,5-bis(2-fluorobenzylidene)piperidin-4-one wound healing HMGA2 HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased wound healing] 1: Homo sapiens Skin | Cell Line, Tumor
2 genes: AQP1 | MAP3K1
1
29. 3,5-bis(2-fluorobenzylidene)piperidin-4-one focal adhesion assembly 3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased focal adhesion assembly 1: Homo sapiens Skin | Cell Line, Tumor   1
30. 3,5-bis(2-fluorobenzylidene)piperidin-4-one epithelial to mesenchymal transition HMGA2 HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in increased epithelial to mesenchymal transition] 1: Homo sapiens Skin | Cell Line, Tumor
3 genes: HIF1A | HMGA2 | STAT3
1
31. 3,5-bis(2-fluorobenzylidene)piperidin-4-one epithelial to mesenchymal transition MIR33B MIR33B mRNA affects the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in increased epithelial to mesenchymal transition] 1: Homo sapiens Skin | Cell Line, Tumor
3 genes: HIF1A | HMGA2 | STAT3
1
32. 3,5-bis(2-fluorobenzylidene)piperidin-4-one cell proliferation 3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased cell proliferation 1: Homo sapiens Skin | Cell Line, Tumor
8 genes: AKT1 | BCL2L1 | HMGA2 | IL12A | IL12B | SRC | STAT3 | TNF
1
33. 3,5-bis(2-fluorobenzylidene)piperidin-4-one stress fiber assembly 3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased stress fiber assembly 1: Homo sapiens Skin | Cell Line, Tumor
2 genes: RHOA | SRC
1
34. 3,5-bis(2-fluorobenzylidene)piperidin-4-one focal adhesion assembly HMGA2 HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased focal adhesion assembly] 1: Homo sapiens Skin | Cell Line, Tumor   1
35. 3,5-bis(2-fluorobenzylidene)piperidin-4-one negative regulation of I-kappaB kinase/NF-kappaB signaling 3,5-bis(2-fluorobenzylidene)piperidin-4-one affects negative regulation of I-kappaB kinase/NF-kappaB signaling 1: Homo sapiens MCF-7 Cells
4 genes: CASP8 | NLRP12 | RHOA | RIPK1
1
36. 3,5-bis(2-fluorobenzylidene)piperidin-4-one cellular response to ionizing radiation 3,5-bis(2-fluorobenzylidene)piperidin-4-one affects cellular response to ionizing radiation 1: Homo sapiens MCF-7 Cells   1
37. 3,5-bis(2-fluorobenzylidene)piperidin-4-one epithelial to mesenchymal transition 3,5-bis(2-fluorobenzylidene)piperidin-4-one results in increased epithelial to mesenchymal transition 1: Homo sapiens Skin | Cell Line, Tumor
3 genes: HIF1A | HMGA2 | STAT3
1
38. 3,5-bis(2-fluorobenzylidene)piperidin-4-one negative regulation of NF-kappaB transcription factor activity 3,5-bis(2-fluorobenzylidene)piperidin-4-one affects negative regulation of NF-kappaB transcription factor activity  
4 genes: IRAK1 | IRAK2 | NFKBIA | NLRP12
1
39. 3,5-bis(2-fluorobenzylidene)piperidin-4-one stress fiber assembly MIR33B MIR33B mRNA affects the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased stress fiber assembly] 1: Homo sapiens Skin | Cell Line, Tumor
2 genes: RHOA | SRC
1
40. 3,5-bis(2-fluorobenzylidene)piperidin-4-one positive regulation of I-kappaB phosphorylation Oxygen 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency affects positive regulation of I-kappaB phosphorylation] 1: Homo sapiens MCF-7 Cells 1 gene: AKT1 1
41. 4-(1H-imidazol-4-ylmethyl)piperidine positive regulation of glutamate secretion, neurotransmission 4-Aminopyridine 4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [4-Aminopyridine results in increased positive regulation of glutamate secretion, neurotransmission] 1: Rattus norvegicus Hippocampus | Synaptosomes   1
42. 4-(1H-imidazol-4-ylmethyl)piperidine positive regulation of glutamate secretion, neurotransmission 4-Aminopyridine | ciproxifan ciproxifan inhibits the reaction [4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [4-Aminopyridine results in increased positive regulation of glutamate secretion, neurotransmission]] 1: Rattus norvegicus Hippocampus | Synaptosomes   1
43. 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide positive regulation of cytosolic calcium ion concentration CCL5 4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [CCL5 protein results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens HEK293 Cells
2 genes: CCL3 | CCR5
1
44. 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine positive regulation of NF-kappaB transcription factor activity 4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene-1-imidazolylacetonitrile | IL4 | Poly I-C 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene-1-imidazolylacetonitrile inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased positive regulation of NF-kappaB transcription factor activity]] 1: Homo sapiens Foreskin | Keratinocytes | Cells, Cultured   1
45. 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine positive regulation of NF-kappaB transcription factor activity amorolfine | IL4 | Poly I-C 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased positive regulation of NF-kappaB transcription factor activity]] 1: Homo sapiens Foreskin | Keratinocytes | Cells, Cultured   1
46. 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine positive regulation of prostaglandin secretion 15-deoxyprostaglandin J2 | butenafine 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [[butenafine results in increased positive regulation of prostaglandin secretion] which results in increased secretion of 15-deoxyprostaglandin J2] 1: Homo sapiens Foreskin | Keratinocytes | Cells, Cultured   1
47. 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine positive regulation of NF-kappaB transcription factor activity IL4 | Poly I-C | terbinafine 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased positive regulation of NF-kappaB transcription factor activity]] 1: Homo sapiens Foreskin | Keratinocytes | Cells, Cultured   1
48. 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine positive regulation of NF-kappaB transcription factor activity butenafine | IL4 | Poly I-C 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased positive regulation of NF-kappaB transcription factor activity]] 1: Homo sapiens Foreskin | Keratinocytes | Cells, Cultured   1
49. 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine positive regulation of NF-kappaB transcription factor activity IL4 | Itraconazole | Poly I-C 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased positive regulation of NF-kappaB transcription factor activity]] 1: Homo sapiens Foreskin | Keratinocytes | Cells, Cultured   1
50. 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine positive regulation of NF-kappaB transcription factor activity IL4 | Ketoconazole | Poly I-C 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased positive regulation of NF-kappaB transcription factor activity]] 1: Homo sapiens Foreskin | Keratinocytes | Cells, Cultured   1
1–50 of 1,347 results.