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Comparative Toxicogenomics Database

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These are exposure studies associated with the chemical and all of its children.

	Reference	Associated Study Title	Author's Summary	Study Factors	Stressor	Receptors	Country	Medium	Exposure Marker	Measurements	Outcome
1.	Herbstman JB, et al. (2008).		Prenatal polychlorinated biphenyls (PCBs) and poly-brominated diphenyl ether (PBDE) exposures were associated with reduced total thyroxine and free thyroxine levels among infants born by spontaneous, unassisted vaginal delivery. Intrapartum stress associated with delivery mode may mask hormonal effects of PCBs and PBDEs.		2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Halogenated Diphenyl Ethers | PCB 180 | pentabromodiphenyl ether | Polychlorinated Biphenyls | Thyrotropin | Thyroxine	Infants or newborns	United States	blood | blood, cord	2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | PCB 180 | pentabromodiphenyl ether | Polychlorinated Biphenyls | Thyrotropin | Thyroxine	Details	thyroid hormone metabolic process
2.	Webster GM, et al. (2016).	National Health and Nutrition Examination Survey (NHANES)	We found evidence of perfluoroalkyl acids-associated thyroid disruption in a subset of U.S. adults with high thyroid peroxidase antibody (a marker of autoimmune hypothyroidism) and low iodine status, who may represent a vulnerable subgroup.	sex	hexadecafluoro-nonanoic acid | Iodine | perfluorohexanesulfonic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid	Study subjects	United States	serum | urine	hexadecafluoro-nonanoic acid | Iodine | perfluorohexanesulfonic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | Thyrotropin | Thyroxine | Triiodothyronine	Details	thyroid hormone metabolic process
3.	Johns LE, et al. (2016).	LifeCodes Prospective Birth Cohort	Overall, the results from our analyses support previous reports showing the potential for environmental phthalate exposure to disturb circulating levels of thyroid hormones in pregnant women.		mono-(2-ethylhexyl)phthalate | monoethyl phthalate | phthalic acid	Pregnant females	United States	plasma | urine	Diethylhexyl Phthalate | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | phthalic acid | Thyroid Hormones | Thyrotropin | Thyroxine | Triiodothyronine	Details	thyroid hormone metabolic process