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Chemical Tissue Plasminogen Activator

Name Tissue Plasminogen Activator
Equivalent Terms Actilyse | Activase | Alteplase | Lysatec rtPA | Lysatec rt PA | Lysatec rt-PA | Plasminogen Activator, Tissue | Plasminogen Activator, Tissue Type | Plasminogen Activator, Tissue-Type | Tisokinase | Tissue Activator D 44 | Tissue Activator D-44 | Tissue Type Plasminogen Activator | Tissue-Type Plasminogen Activator | T Plasminogen Activator | T-Plasminogen Activator | TTPA
Definition A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Curation Status No gene interactions have been curated for this chemical yet.
MeSH® ID D010959
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Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Blood Coagulation Factors Has associated genes Has associated diseases Has associated exposure references Tissue Plasminogen Activator Has associated diseases

Top ↑ Descendants

Tissue Plasminogen Activator Has associated diseases
  amediplase
  arginyl-asparagyl-prolyl-aspartyl-glycyl-aspartyl-alanyl-lysyl-prolyl-tryptophan
  delta(2-89)-tissue plasminogen activator
  D-K2P
  duteplase Has associated diseases
  FK2P tissue plasminogen activator
  lanoteplase Has associated diseases
  lekteplase
  LY 210825
  pamiteplase
  PLAT protein, human
  reteplase Has associated diseases
  T103N
  T103N, KHRR 296-299 AAAA
  technetium Tc 99m-tissue-type plasminogen activator
  tenecteplase Has associated diseases
  Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator
  tissue plasminogen activator-(staphylococcal A, B fragment) dimer Has associated diseases
  TNK-tissue plasminogen activator
  unglycosylated rt-PA