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Chemical Polycyclic Compounds

These are exposure studies associated with the chemical and all of its children.

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  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Sexton K, et al. (2007). Our aim was to compare and rank relative health risks of 179 air pollutants in Houston using an evidence-based approach supplemented by the expert judgment of a panel of academic scientists. 1,1,2,2-tetrachloroethane | 1,3-butadiene | 1,6-hexamethylene diisocyanate | Acetaldehyde | Acrolein | acrylic acid | Acrylonitrile | Arsenicals | Benzene | Carbon Tetrachloride | Chlorine | chromium hexavalent ion | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Formaldehyde | naphthalene | Ozone | Particulate Matter | Vehicle Emissions | Vinyl Chloride Study subjects United States Details Disorders of Environmental Origin | Neoplasms
2. Loh MM, et al. (2007). In this study we compared cancer risks from organic hazardous air pollutants (HAPs) based on total personal exposure summed across different microenvironments and exposure pathways. 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 1,3-dichloro-1-propene | 4-dichlorobenzene | Acetaldehyde | anthracene | benz(a)anthracene | Benzene | Benzo(a)pyrene | benzo(b)fluoranthene | Carbon Tetrachloride | Chloroform | chrysene | Dioxins | Ethylene Dibromide | ethylene dichloride | fluoranthene | Formaldehyde | indeno(1,2,3-cd)pyrene | Methylene Chloride | naphthalene | phenanthrene | Polycyclic Aromatic Hydrocarbons | pyrene | Tetrachloroethylene | Trichloroethylene | Vinyl Chloride Study subjects United States 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 1,3-dichloro-1-propene | 4-dichlorobenzene | Acetaldehyde | anthracene | benz(a)anthracene | Benzene | Benzo(a)pyrene | benzo(b)fluoranthene | Carbon Tetrachloride | Chloroform | chrysene | Dioxins | Ethylene Dibromide | ethylene dichloride | fluoranthene | Formaldehyde | indeno(1,2,3-cd)pyrene | Methylene Chloride | naphthalene | phenanthrene | Polycyclic Aromatic Hydrocarbons | pyrene | Tetrachloroethylene | Trichloroethylene | Vinyl Chloride Details Neoplasms
3. Aquilina NJ, et al. (2010). Measurement and Modelling of Air Toxic Concentrations for Health Effect Studies Project (MATCH) The objective of this study was to analyse environmental tobacco smoke (ETS) and polycyclic aromatic hydrocarbon (PAH) metabolites in urine samples of non-occupationally exposed non-smoker adult subjects and to establish relationships between airborne exposures and urinary concentrations in order to assess the suitability of the studied metabolites as biomarkers of PAH and ETS, study the use of 3-ethenypyridine as ETS tracer, and link ETS scenarios with exposures to carcinogenic PAH and volatile organic compounds. tobacco 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 1-hydroxyphenanthrene | 1-hydroxypyrene | 2-hydroxyfluorene | 2-naphthol | 3-vinylpyridine | acenaphthene | acenaphthylene | anthracene | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | chrysene | coronene | fluoranthene | fluorene | hydroxycotinine | indeno(1,2,3-cd)pyrene | naphthalene | Nicotine | phenanthrene | Polycyclic Aromatic Hydrocarbons | pyrene Study subjects United Kingdom urine 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 1-hydroxyphenanthrene | 1-hydroxypyrene | 2-hydroxyfluorene | 2-naphthol | 3-vinylpyridine | acenaphthene | acenaphthylene | anthracene | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | chrysene | coronene | fluoranthene | fluorene | hydroxycotinine | indeno(1,2,3-cd)pyrene | naphthalene | Nicotine | phenanthrene | Polycyclic Aromatic Hydrocarbons | pyrene Details
4. von Ehrenstein OS, et al. (2016). California Cancer Registry Our data suggest that in utero and infancy exposures to air toxics generated by industrial and road traffic sources may increase the risk of primitive neuroectodermal tumor and medulloblastoma, with limited support for increased risks for astrocytoma in children up to age 6. 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 2-dichlorobenzene | 2-xylene | 4-dichlorobenzene | Acetaldehyde | Benzene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | Chloroform | Chromium | chromium hexavalent ion | ethylbenzene | Formaldehyde | indeno(1,2,3-cd)pyrene | Lead | Methylene Chloride | Nickel | Polycyclic Aromatic Hydrocarbons | Selenium | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene Controls for disease:Neuroectodermal Tumors, Primitive | Subjects with disease:Neuroectodermal Tumors, Primitive United States air 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | 1,3-butadiene | 2-dichlorobenzene | 2-xylene | 4-dichlorobenzene | Acetaldehyde | Benzene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | Chloroform | Chromium | chromium hexavalent ion | ethylbenzene | Formaldehyde | indeno(1,2,3-cd)pyrene | Lead | Methylene Chloride | Nickel | Polycyclic Aromatic Hydrocarbons | Selenium | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene Details Astrocytoma | Medulloblastoma | Neuroectodermal Tumors, Primitive
5. Choi H, et al. (2008). Prenatal polycyclic aromatic hydrocarbon exposure is likely to contribute to the occurrence of small size for gestational age as well as preterm births among African Americans. 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | chrysene | indeno(1,2,3-cd)pyrene | Polycyclic Aromatic Hydrocarbons Pregnant females United States air 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | chrysene | indeno(1,2,3-cd)pyrene | Polycyclic Aromatic Hydrocarbons Details Fetal Growth Retardation | Premature Birth | Prenatal Exposure Delayed Effects
6. Tonne CC, et al. (2004). In this study, we examined levels of exposures to polycyclic aromatic hydrocarbons and tested for associations with potential predictor variables collected from questionnaires addressing socioeconomic factors and day-to-day activities during pregnancy as well as activities and environmental exposures during the 48-hr monitoring period. 1,12-benzoperylene | 1,2,5,6-dibenzanthracene | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | chrysene | indeno(1,2,3-cd)pyrene | Polycyclic Aromatic Hydrocarbons | pyrene Pregnant females Croatia|France|
Italy|United States
1,12-benzoperylene | 1,2,5,6-dibenzanthracene | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(k)fluoranthene | chrysene | indeno(1,2,3-cd)pyrene | Polycyclic Aromatic Hydrocarbons | pyrene Details
7. Dodson RE, et al. (2015). California Household Exposure Study (CAHES) We collected house dust and indoor air samples in 49 California homes and analyzed for 76 semivolatile organic compounds-phthalates, polybrominated diphenyl ethers, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and pesticides. 1,2,5,6-dibenzanthracene | 1-methylphenanthrene | 1-nitropyrene | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4'-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | 2-methylphenanthrene | 2-phenylphenol | 4,6-dimethyldibenzothiophene | 4-nitrotoluene | acenaphthene | acenaphthylene | alachlor | Aldrin | anthracene | Atrazine | bendiocarb | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(j)fluoranthene | benzo(k)fluoranthene | benzothiophene | butylbenzyl phthalate | Carbaryl | Carbofuran | Chlordan | Chlorpyrifos | chrysene | cyanazine | cypermethrin | DDT | Diazinon | dibenzo(a,e)pyrene | dibenzothiophene | Dibutyl Phthalate | Dichlorodiphenyldichloroethane | Dichlorodiphenyl Dichloroethylene | Dicofol | dicyclohexyl phthalate | Dieldrin | Diethylhexyl Phthalate | diethyl phthalate | diisobutyl phthalate | di-n-hexyl phthalate | di-n-octyl phthalate | di-n-pentyl phthalate | di-n-propylphthalate | dioctyl adipate | Endrin | fluoranthene | fluorene | Heptachlor | indeno(1,2,3-cd)pyrene | Lindane | Malathion | Methoxychlor | Methyl Parathion | metolachlor | nitrofen | Parathion | pentabromodiphenyl ether | Permethrin | phenanthrene | Phenanthrenes | Piperonyl Butoxide | prometone | Propoxur | pyrene | Simazine | tetrachloroisophthalonitrile | Trifluralin | tris(2,3-dibromopropyl)phosphate United States dust 1,2,5,6-dibenzanthracene | 1-methylphenanthrene | 1-nitropyrene | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4'-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | 2-methylphenanthrene | 2-phenylphenol | 4,6-dimethyldibenzothiophene | 4-nitrotoluene | acenaphthene | acenaphthylene | alachlor | Aldrin | anthracene | Atrazine | bendiocarb | benz(a)anthracene | Benzo(a)pyrene | benzo(b)fluoranthene | benzo(j)fluoranthene | benzo(k)fluoranthene | benzothiophene | butylbenzyl phthalate | Carbaryl | Carbofuran | Chlordan | Chlorpyrifos | chrysene | cyanazine | cypermethrin | DDT | Diazinon | dibenzo(a,e)pyrene | dibenzothiophene | Dibutyl Phthalate | Dichlorodiphenyldichloroethane | Dichlorodiphenyl Dichloroethylene | Dicofol | dicyclohexyl phthalate | Dieldrin | Diethylhexyl Phthalate | diethyl phthalate | diisobutyl phthalate | di-n-hexyl phthalate | di-n-octyl phthalate | di-n-pentyl phthalate | di-n-propylphthalate | dioctyl adipate | Endrin | fluoranthene | fluorene | Heptachlor | indeno(1,2,3-cd)pyrene | Lindane | Malathion | Methoxychlor | Methyl Parathion | metolachlor | nitrofen | Parathion | pentabromodiphenyl ether | Permethrin | phenanthrene | Phenanthrenes | Piperonyl Butoxide | prometone | Propoxur | pyrene | Simazine | tetrachloroisophthalonitrile | Trifluralin | tris(2,3-dibromopropyl)phosphate Details
8. Rull RP, et al. (2006). Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. 1,3-dichloro-1-propene | Amides | Benomyl | Benzimidazoles | Captan | Chlorpyrifos | devrinol | Dimethoate | Disulfoton | Methomyl | methyl carbamate | methyl demeton | Naled | Organophosphorus Compounds | vendex Infants or newborns United States 1,3-dichloro-1-propene | Amides | Benomyl | Benzimidazoles | Captan | Chlorpyrifos | devrinol | Dimethoate | Disulfoton | Methomyl | methyl carbamate | methyl demeton | Naled | Organophosphorus Compounds | vendex Details Anencephaly | Neural Tube Defects | Spinal Dysraphism
9. Pronk A, et al. (2006). The aim of this study was to assess which compounds contribute to isocyanate exposure in car body repair shops and industrial painting companies, and to identify tasks with a high risk of isocyanate exposure. 1,6-hexamethyleneaminoisocyanate | 1,6-hexamethylene diisocyanate | 2,6-diisocyanatotoluene | 4,4'-diphenylmethane diisocyanate | Biuret | ethyl isocyanate | Isocyanates | isophorone diisocyanate | methyl isocyanate | phenyl isocyanate | Toluene 2,4-Diisocyanate Workers Netherlands 1,6-hexamethyleneaminoisocyanate | 1,6-hexamethylene diisocyanate | 2,6-diisocyanatotoluene | 4,4'-diphenylmethane diisocyanate | Biuret | ethyl isocyanate | Isocyanates | isophorone diisocyanate | methyl isocyanate | phenyl isocyanate | Toluene 2,4-Diisocyanate Details
10. Tuakuila J, et al. (2013). This study reveals the high pyrene (PAH) exposure of the Kinshasa population requiring the determination of PAH concentrations in ambient air of Kinshasa and limits values for the protection of human health. tobacco 1-hydroxypyrene Study subjects Congo, the Democratic Republic of the urine 1-hydroxypyrene Details
11. Ji G, et al. (2010). Nanjing Medical University Infertile Study These findings provided the first evidence that polymorphisms of XRCC1 may modify sperm Polycyclic Aromatic Hydrocarbons-DNA adduct levels and may be useful biomarkers to identify individuals susceptible to DNA damage resulting from PAHs exposure. genetics 1-hydroxypyrene Subjects with disease:Infertility, Male China urine 1-hydroxypyrene Details Infertility, Male
12. Woodruff TJ, et al. (2011). National Health and Nutrition Examination Survey (NHANES) Our analysis of the NHANES pregnancy data shows ubiquitous exposure to multiple chemicals during a sensitive period of fetal development. 1-hydroxypyrene | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2-naphthol | 4-dichlorobenzene | Benzene | bisphenol A | Cadmium | Cotinine | DDT | Dichlorodiphenyl Dichloroethylene | diethyl phosphate | dimethyl phosphate | fluoren-9-ol | Hexachlorobenzene | Lead | Mercury | methyl tert-butyl ether | mono-benzyl phthalate | monobutyl phthalate | mono-isobutyl phthalate | O,O-dimethyl phosphorodithioate | O,O-dimethyl phosphorothionate | oxybenzone | PCB 180 | perchlorate | perfluorooctane sulfonic acid | perfluorooctanoic acid | thiophosphoric acid | Toluene | Triclosan Pregnant females | Study subjects United States blood | serum | urine 1-hydroxypyrene | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2-naphthol | 4-dichlorobenzene | Benzene | bisphenol A | Cadmium | Cotinine | DDT | Dichlorodiphenyl Dichloroethylene | diethyl phosphate | dimethyl phosphate | fluoren-9-ol | Hexachlorobenzene | Lead | Mercury | methyl tert-butyl ether | mono-benzyl phthalate | monobutyl phthalate | mono-isobutyl phthalate | O,O-dimethyl phosphorodithioate | O,O-dimethyl phosphorothionate | oxybenzone | PCB 180 | perchlorate | perfluorooctane sulfonic acid | perfluorooctanoic acid | thiophosphoric acid | Toluene | Triclosan Details
13. Johnson NM, et al. (2010). Findings suggest that the incidence and level of aflatoxins and polycyclic aromatic hydrocarbon exposure was less than that observed in a high-risk population; however, participants consuming higher amounts of foods prone to aflatoxin contamination may be more vulnerable to exposure and interactions with other environmental/biological factors (i.e., hepatitis C virus). diet 1-hydroxypyrene | Aflatoxin M1 Study subjects United States urine 1-hydroxypyrene | Aflatoxin M1 Details
14. Brody JG, et al. (2009). Northern California Household Exposure Study In this study, we found that cumulative air pollution burdens were more pronounced indoors than outdoors in an urban industrial environmental justice community in comparison with a rural community. 1-methylphenanthrene | 2-methylphenanthrene | 2-phenylphenol | acenaphthene | Aluminum | Ammonia | Calcium | Carbon | Copper | Diethylhexyl Phthalate | dioctyl adipate | fluoranthene | fluorene | Iron | Lead | Manganese | Nitrates | Particulate Matter | phenanthrene | Potassium | pyrene | Sulfates | Vanadium United States air, indoor | air, outdoor 1-methylphenanthrene | 2-methylphenanthrene | 2-phenylphenol | acenaphthene | Aluminum | Ammonia | Calcium | Carbon | Copper | Diethylhexyl Phthalate | dioctyl adipate | fluoranthene | fluorene | Iron | Lead | Manganese | Nitrates | Particulate Matter | phenanthrene | Potassium | pyrene | Sulfates | Vanadium Details
15. Bradman A, et al. (2003). As a first step in validating this (amniotic fluid) exposure biomarker, we collected 100 amniotic fluid samples slated for disposal and evaluated analytical methods to measure organophosphate and carbamate pesticides and metabolites, synthetic pyrethroid metabolites, herbicides, and chlorinated phenolic compounds. 1-naphthol | 2,5-dichlorophenol | 2-naphthol | 2-phenylphenol | Carbofuran | diethyl phosphate | dimethyl phosphate | O,O-dimethyl phosphorothionate | Pentachlorophenol Mothers United States amniotic fluid 1-naphthol | 2,5-dichlorophenol | 2-naphthol | 2-phenylphenol | Carbofuran | diethyl phosphate | dimethyl phosphate | O,O-dimethyl phosphorothionate | Pentachlorophenol Details
16. Meeker JD, et al. (2004). In the present study we found associations between urinary metabolites of contemporary-use insecticides and decreased sperm concentration and motility in humans. 1-naphthol | 3,5,6-trichloro-2-pyridinol | Insecticides Subjects with disease:Infertility, Male United States semen | urine 1-naphthol | 3,5,6-trichloro-2-pyridinol Details Infertility, Male | spermatogenesis | sperm motility
17. Ayotte P, et al. (2005). In summary, we found no relation between biomarkers of organochlorine exposure and markers of hepatic enzyme induction in this highly exposed group of fish eaters from the Lower North Shore of the St. Lawrence River. Our results suggest that smoking induces liver CYP1A2 activity, which in turn alters porphyrin metabolism and increases the biotransformation of mono-ortho polychlorinated biphenyls. tobacco 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Hydrocarbons, Chlorinated | Mirex | nonachlor | oxychlordane | PCB 180 | Polychlorinated Biphenyls Study subjects Canada plasma | urine 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Coproporphyrins | Dichlorodiphenyl Dichloroethylene | Glucaric Acid | Hexachlorobenzene | Hydrocarbons, Chlorinated | Mirex | nonachlor | oxychlordane | PCB 180 | Polychlorinated Biphenyls | Uroporphyrins Details enzyme activator activity
18. Vested A, et al. (2014). The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | PCB 180 | Polychlorinated Biphenyls Mothers | Study subjects Denmark semen | serum 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | Estradiol | FSHB | INHBB | LHB | PCB 180 | SHBG | Testosterone Details spermatogenesis | sperm motility
19. Patel CJ, et al. (2012). National Health and Nutrition Examination Survey (NHANES) We screened for correlation between environmental factors and lipid levels, utilizing four independent surveys with information on 188 environmental factors from the Centers of Disease Control, National Health and Nutrition Examination Survey, collected between 1999 and 2006. age | body mass index | race | sex | socioeconomic status 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,3-bis(3'-hydroxybenzyl)butyrolactone | 2,4,4',5-tetrachlorobiphenyl | 2-hydroxyfluorene | alpha-Tocopherol | Ascorbic Acid | beta Carotene | Cotinine | Cryptoxanthins | Fluorenes | Folic Acid | gamma-Tocopherol | Heptachlor Epoxide | Iron | lycopene | Mercury | nonachlor | oxychlordane | retinol palmitate | retinyl stearate | Vitamin A | Vitamin D Study subjects United States Details cholesterol metabolic process | triglyceride metabolic process
20. Chevrier J, et al. (2007). Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) In summary, we report a positive association between neonatal thyroid-stimulating hormone levels and prenatal exposure to polychlorinated biphenyls (PCBs) reported to induce microsomal enzymes (specifically CYP2B) and suspected to induce uridinediphosphate glucuronosyltransferase in animals but not with the sum of all PCB congeners, or PCBs grouped according to their dioxin-like activity or structure. 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | PCB 180 | Polycyclic Aromatic Hydrocarbons Pregnant females United States serum 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | PCB 180 | Polycyclic Aromatic Hydrocarbons Details hormone metabolic process
21. Gagnon F, et al. (2004). A survey was carried out on 162 recreational harvesters, and shellfish were sampled for chemical contaminant analysis. 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | Arsenic | benzo(e)pyrene | Cadmium | Chlordan | Chromium | Copper | DDT | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Lead | Manganese | Mercury | naphthalene | Nickel | nonachlor | Polychlorinated Biphenyls | Selenium | Zinc Workers Canada 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | Arsenic | benzo(e)pyrene | Cadmium | Chlordan | Chromium | Copper | DDT | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Lead | Manganese | Mercury | naphthalene | Nickel | nonachlor | Polychlorinated Biphenyls | Selenium | Zinc Details
22. Turyk ME, et al. (2008). Consortium for the health assessment of Great Lakes sport fish consumption Polychlorinated biphenyls exposure, at levels comparable with those of the general U.S. population, was associated with increased thyroglobulin antibodies and increased T(4) in adult males. 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Dichlorodiphenyl Dichloroethylene | Halogenated Diphenyl Ethers | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | Polychlorinated Biphenyls Study subjects United States serum | urine 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Dichlorodiphenyl Dichloroethylene | Halogenated Diphenyl Ethers | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | Polychlorinated Biphenyls | SERPINA7 | Testosterone | Thyrotropin | Thyroxine | Triiodothyronine Details immunoglobulin production | testosterone biosynthetic process | thyroid hormone metabolic process
23. Johansson GM, et al. (2015). This first study of amine adducts in hairdressers and consumers identified an increase in o- and m-toluidine Hb-adduct concentrations among hairdressers, associated with the weekly number of hair dye and hair waving treatments performed. 2,3-didehydro-5-O-mycaminosyl-23-O-acetyltylonolide | 2-toluidine | 3-toluidine | 4-toluidine Study subjects | Workers Sweden blood 2,3-didehydro-5-O-mycaminosyl-23-O-acetyltylonolide | 2-toluidine | 3-toluidine | 4-toluidine Details
24. Goldner WS, et al. (2010). Agricultural Health Study (AHS) These data support a role of organochlorines, in addition to fungicides, in the etiology of thyroid disease among female spouses enrolled in the Agricultural Health Study. 2,4,5-Trichlorophenoxyacetic Acid | 2,4-Dichlorophenoxyacetic Acid | alachlor | Aldrin | Atrazine | Benomyl | butylate | Captan | Carbaryl | Carbon Disulfide | Carbon Tetrachloride | Chlordan | chlorimuron ethyl | Chlorpyrifos | cyanazine | DDT | Diazinon | Dicamba | Dichlorvos | EPTC | Fonofos | Fungicides, Industrial | glyphosate | Heptachlor | Hydrocarbons, Chlorinated | imazethapyr | Insecticides | Lindane | Malathion | mancozeb | Maneb | metalaxyl | methyl bromide | metolachlor | metribuzin | Paraquat | Parathion | pendimethalin | Petroleum | terbufos | tetrachloroisophthalonitrile | Trifluralin Study subjects United States Details Agricultural Workers' Diseases | Hyperthyroidism | Hypothyroidism
25. Hoppin JA, et al. (2007). Agricultural Health Study (AHS) These results provide preliminary evidence that pesticide use may increase chronic bronchitis prevalence. 2,4,5-Trichlorophenoxyacetic Acid | Carbaryl | Carbofuran | chlorimuron ethyl | DDT | Diazinon | Dichlorvos | fenoprop | Heptachlor | Malathion | Permethrin Workers United States Details Agricultural Workers' Diseases | Bronchitis, Chronic
26. Koutros S, et al. (2011). Agricultural Health Study (AHS) We evaluated pesticide-single nucleotide polymorphism (SNP) interactions between 45 pesticides and 1913 xenobiotic metabolic enzyme SNPs with respect to prostrate cancer among 776 cases and 1444 controls in the Agricultural Health Study. genetics 2,4,5-Trichlorophenoxyacetic Acid | Carbaryl | Diazinon | Dieldrin | Fonofos | Lindane | methyl bromide | Petroleum | Phorate | terbufos Subjects with gene influence:GCLC | Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
27. Hoppin JA, et al. (2017). Agricultural Health Study (AHS) We evaluated the association of currently used pesticides with allergic and non-allergic wheeze among male farmers, and our results implicate several pesticides that are commonly used in agricultural and residential settings with adverse respiratory effects. 2,4-Dichlorophenoxyacetic Acid | acetochlor | Atrazine | bentazone | Carbaryl | Chlorpyrifos | clomazone | clopyralid | cyfluthrin | Dicamba | Dimethoate | Disulfoton | fenoxaprop ethyl | fluazifop-butyl | glyphosate | Herbicides | imazaquin | Insecticides | Malathion | mesotrione | metolachlor | N-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide | nicosulfuron | Permethrin | Petroleum | Picloram | Pyrethrins | Rodenticides | Simazine | triclopyr | Trifluralin | Warfarin Workers United States Details Respiratory Sounds | Rhinitis, Allergic
28. Hoppin JA, et al. (2002). Agricultural Health Study (AHS) Prevalence of wheeze was associated with individual pesticides independent of animals, crops, and grains. disease 2,4-Dichlorophenoxyacetic Acid | alachlor | Aldicarb | aluminum phosphide | Atrazine | Benomyl | butylate | Captan | Carbaryl | Carbofuran | chlorimuron ethyl | Chlorpyrifos | Coumaphos | cyanazine | Diazinon | Dicamba | Dichlorvos | EPTC | Fonofos | glyphosate | imazethapyr | Lindane | Malathion | Maneb | metalaxyl | metolachlor | metribuzin | Paraquat | Parathion | pendimethalin | Permethrin | Petroleum | Phorate | terbufos | tetrachloroisophthalonitrile | Trichlorfon | Trifluralin | Ziram Subjects with disease:Asthma | Subjects with disease:Ige Responsiveness, Atopic | Workers United States Details Agricultural Workers' Diseases | Respiratory Sounds
29. Lee WJ, et al. (2007). Agricultural Health Study (AHS) This explorative study suggests an association between the incidence of colorectal cancer and use of certain pesticides, in particularly chlorpyrifos and aldicarb, although some findings could be due to chance. age | body mass index | tobacco 2,4-Dichlorophenoxyacetic Acid | Aldicarb | Carbaryl | Chlorpyrifos | Fonofos | Toxaphene Workers United States Details Agricultural Workers' Diseases | Colorectal Neoplasms | Rectal Neoplasms
30. Hoppin JA, et al. (2008). Agricultural Health Study (AHS) These findings suggest that pesticides may contribute to atopic asthma, but not nonatopic asthma, among farm women. 2,4-Dichlorophenoxyacetic Acid | Carbamates | Carbaryl | Coumaphos | DDT | glyphosate | Hydrocarbons, Chlorinated | Malathion | metalaxyl | Organophosphates | Parathion | Permethrin | Pesticides | Phorate Study subjects United States Details Agricultural Workers' Diseases | Asthma
31. Palacios C, et al. (2012). In this group of overweight and obese individuals, 25-Hydroxyvitamin D was significantly related to vitamin D intake, sun exposure and vitamin D intake indices and percent body fat. body mass index | diet 25-hydroxyvitamin D | Vitamin D Study subjects Puerto Rico serum 25-hydroxyvitamin D | Vitamin D Details
32. Logue JM, et al. (2012). The approach demonstrated in this study may be used to assess regional and national initiatives that affect indoor air quality at the population level. Cumulative health impacts from inhalation in U.S. residences of the indoor air pollutants assessed in this study are estimated at 400-1,100 disability-adjusted life years lost annually per 100,000 persons. Air Pollutants United States 1,1,1,2-tetrachloroethane | 1,1,2-trichloroethane | 1,3-butadiene | 2-butenal | 2-ethoxyethanol | 2-ethylhexanol | 2-phenylphenol | 2-xylene | 4-dichlorobenzene | Acetaldehyde | Acrolein | Acrylonitrile | Ammonia | Arsenic | Atrazine | Benzaldehydes | Benzene | Benzo(a)pyrene | benzyl chloride | Beryllium | bromodichloromethane | bromoform | Cadmium | Carbon Disulfide | Carbon Monoxide | Carbon Tetrachloride | chlorobenzene | chlorodibromomethane | Chloroform | Chromium | cumene | Cyclohexane | Diethylhexyl Phthalate | dioctyl adipate | Ethanol | ethylbenzene | Ethyl Chloride | Ethylene Dibromide | ethylene dichloride | Formaldehyde | hexachlorobutadiene | Manganese | Mercury | methyl cellosolve | Methyl Chloride | Methylene Chloride | methylethyl ketone | methyl isobutyl ketone | Methylmethacrylate | methyl tert-butyl ether | naphthalene | n-butoxyethanol | Nitrogen Dioxide | Ozone | Particulate Matter | Pentachlorophenol | Styrene | Sulfur Dioxide | Tetrachloroethylene | tetrahydrofuran | Toluene | Trichloroethylene | Vinyl Chloride | vinylidene chloride | Xylenes Details
33. Windham GC, et al. (2006). Our results suggest a potential association between autism and estimated metal concentrations, and possibly chlorinated solvents, in ambient air around the birth residence, requiring confirmation and more refined exposure assessment in future studies. Air Pollutants Controls for disease:Autism Spectrum Disorder | Subjects with disease:Autism Spectrum Disorder | Children United States air, ambient Arsenic | Benzene | Cadmium | Chromium | ethylbenzene | hydrazine | Hydrocarbons, Chlorinated | Lead | Manganese | Mercury | Metals, Heavy | Methylene Chloride | Nickel | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Solvents | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Details Autism Spectrum Disorder
34. Wertheim HF, et al. (2012). High levels of urine hydroxy-polycyclic aromatic hydrocarbons were found in Hanoi street workers. No effect was seen on urine levels by wearing R95 particulate respirators in an area of high urban air pollution, except for 1-hydroxynaphthalene. Air Pollutants Workers Vietnam urine 1-hydroxyphenanthrene | 1-hydroxypyrene | 2-hydroxyfluorene | 4-hydroxyphenanthrene | fluoren-9-ol Details
35. López-Abente G, et al. (2012). Statistically significant relative risks for colorectal cancer mortality at a municipal level were detected in the vicinity of mining industry, paper and wood production, food and beverage sector, metal production and processing installations, and ceramics. Air Pollutants Study subjects Spain air, outdoor 1,1,1-trichloroethane | Ammonia | anthracene | Antimony | Arsenicals | Arsenic | Benzene | beta-hexachlorocyclohexane | Cadmium | Cadmium Compounds | Carbon Dioxide | Carbon Monoxide | Carbon Tetrachloride | Chlorine | Chlorine Compounds | Chlorofluorocarbons | Chloroform | Chromium | Chromium Compounds | Cobalt | Diethylhexyl Phthalate | Dioxins | ethylene dichloride | Ethylene Oxide | Fluorine | Fluorine Compounds | Hexachlorobenzene | Hydrogen Cyanide | Lead | Manganese | Manganese Compounds | Mercury | Mercury Compounds | Methane | Methylene Chloride | naphthalene | Nickel | Nitrogen Oxides | Nitrous Oxide | Particulate Matter | Pentachlorophenol | Polychlorinated Biphenyls | Sulfur Oxides | Tetrachloroethylene | Thallium | trichlorobenzene | Trichloroethylene | Vanadium | Vanadium Compounds | Vinyl Chloride | Zinc | Zinc Compounds Details Colorectal Neoplasms | Death
36. Kalkbrenner AE, et al. (2010). Autism and Developmental Disabilities Monitoring Network (ADDM) Our screening design was limited by exposure misclassification of air pollutants and the use of an alternate developmental disorder as the control group, both of which may have biased results toward the null. Despite these limitations, methylene chloride, quinoline, and styrene emerged (based on this analysis and prior epidemiologic evidence) as candidates that warrant further investigation for a possible role in autism etiology. Air Pollutants United States air 1,1,2,2-tetrachloroethane | 1,3-butadiene | 1,3-dichloro-1-propene | Acetaldehyde | Acrolein | Acrylonitrile | Arsenicals | Benzene | Beryllium | Cadmium Compounds | Carbon Tetrachloride | Chloroform | Chromium Compounds | Coke | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Formaldehyde | Hexachlorobenzene | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methylene Chloride | methyl tert-butyl ether | Nickel | Polychlorinated Biphenyls | Polycyclic Aromatic Hydrocarbons | propionaldehyde | propylene dichloride | quinoline | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vehicle Emissions | Vinyl Chloride | Xylenes Details Autism Spectrum Disorder
37. Wittkopp S, et al. (2016). Cardiovascular Health and Air Pollution Study We report novel associations of gene expression changes with traffic-related air pollution exposures in a Los Angeles cohort of elderly subjects with coronary artery disease in this exploratory panel study analysis. Air Pollutants | Carbon | Carbon Monoxide | hopane | Nitrogen Dioxide | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Subjects with disease:Coronary Artery Disease United States air | blood Carbon | Carbon Monoxide | CYP1B1 | HMOX1 | hopane | IL1B | NFE2L2 | Nitrogen Dioxide | Nitrogen Oxides | NQO1 | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | SELP | SOD2 | Soot Details gene expression
38. Delfino RJ, et al. (2010). Traffic emission sources of organic chemicals represented by polycyclic aromatic hydrocarbons are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass. Air Pollutants | hopane | Polycyclic Aromatic Hydrocarbons | Vehicle Emissions Subjects with disease:Coronary Artery Disease United States air, outdoor | plasma Alkanes | Chromium | Copper | hopane | IL6 | Iron | Manganese | Nickel | Particulate Matter | Polycyclic Aromatic Hydrocarbons | TNFRSF1B | Vanadium | Zinc Details
39. Perera F, et al. (2008). The findings indicate that neurobehavioral development in Tongliang children benefited by elimination of polycyclic aromatic hydrocarbons (PAH) exposure from the coal-burning plant, consistent with the significant reduction in PAH-DNA adducts in cord blood of children in the 2005 cohort. Air Pollutants | Lead | Mercury | Polycyclic Aromatic Hydrocarbons | Tobacco Smoke Pollution Infants or newborns China blood, cord Lead | Mercury | polycyclic aromatic hydrocarbons-DNA adduct | Tobacco Smoke Pollution Details Prenatal Exposure Delayed Effects | cognition | motor activity
40. Gong J, et al. (2015). Sampling data for pre-, during-, and post-Olympic time periods in Beijing (China), this study found evidence that 1-naphthylamine and 2-naphthylamine (co-assayed) and 1-hydroxypyrene can be used as biomarkers of exposure to general vehicle-emitted pollutants; more data are needed to confirm 1-aminopyrene as a biomarker of diesel combustion emissions. Air Pollutants | Vehicle Emissions Study subjects China air, ambient | urine 1-aminopyrene | 1-hydroxypyrene | 1-Naphthylamine | 2-Naphthylamine | Carbon Monoxide | Nitrates | Nitrogen Dioxide | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | pyrene | Soot | Sulfates | Sulfur Dioxide Details
41. Andreotti G, et al. (2010). Agricultural Health Study (AHS) Using data from the Agricultural Health Study, we examined the association between body mass index (BMI) and the risk of cancer at 17 sites and the interaction between BMI and pesticide use. body mass index | tobacco alachlor | Atrazine | Carbaryl | Carbofuran | chlorimuron ethyl | Chlorpyrifos | cyanazine | DDT | Diazinon | EPTC | Fonofos | glyphosate | Hydrocarbons, Chlorinated | imazethapyr | Malathion | methyl bromide | metolachlor | metribuzin | Organophosphates | pendimethalin | Permethrin | terbufos | Trifluralin Study subjects | Workers United States Details Agricultural Workers' Diseases | Breast Neoplasms | Colonic Neoplasms | Lung Neoplasms
42. Christensen CH, et al. (2016). Agricultural Health Study (AHS) In this case-control study nested within the Agricultural Health Study cohort, we evaluated evidence of statistical interaction between pesticide exposure and single nucleotide polymorphisms in genes involved in steroid hormone signaling, metabolism, or regulation with the risk of prostate cancer. genetics alachlor | butylate | Carbaryl | Dicamba | Fonofos | Malathion | terbufos Subjects with gene influence:ESR1 | Subjects with gene influence:HSD17B4 | Subjects with gene influence:SHBG | Subjects with gene influence:SRD5A1 | Subjects with gene influence:SULT2A1 | Workers United States Details Prostatic Neoplasms
43. Cakmak S, et al. (2014). Canadian Health Measures Survey (CHMS) To investigate the association between volatile organic compounds measured in residential indoor air and lung function in the Canadian population Cycle 2 of the Canadian Health Measures Survey - a population based cross-sectional survey designed to be representative of the Canadian population - was carried out between 2009 and 2011. alpha-pinene | Benzene | caprylic aldehyde | decanaldehyde | Furaldehyde | isoprene | naphthalene | n-hexanal | nonanal | Styrene Children | Study subjects Canada air alpha-pinene | Benzene | caprylic aldehyde | decanaldehyde | Furaldehyde | isoprene | naphthalene | n-hexanal | nonanal | Styrene Details regulation of respiratory gaseous exchange
44. Shin HM, et al. (2014). Early Autism Risk Longitudinal Investigation (EARLI) A total of six phthalates, four personal care product ingredients, and five flame retardants were analyzed in household dust from 30 homes in three different regions in the U.S. Aminobenzoates | Benzopyrans | butylbenzyl phthalate | Dibutyl Phthalate | Diethylhexyl Phthalate | diethyl phthalate | diisobutyl phthalate | diisononyl phthalate | Flame Retardants | octylmethoxycinnamate | Tetrahydronaphthalenes | triphenyl phosphate | tris(1,3-dichloro-2-propyl)phosphate | tris(chloroethyl)phosphate United States dust Aminobenzoates | Benzopyrans | butylbenzyl phthalate | Dibutyl Phthalate | Diethylhexyl Phthalate | diethyl phthalate | diisobutyl phthalate | diisononyl phthalate | Flame Retardants | octylmethoxycinnamate | Tetrahydronaphthalenes | triphenyl phosphate | tris(1,3-dichloro-2-propyl)phosphate | tris(chloroethyl)phosphate Details
45. Fénichel P, et al. (2012). The presence of unconjugated bisphenol A in all cord blood samples suggests placental transfer and fetal exposure. Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Controls for disease:Cryptorchidism | Subjects with disease:Cryptorchidism | Infants or newborns France blood, cord Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Details
46. Adgent MA, et al. (2015). National Health and Nutrition Examination Survey (NHANES) Antibiotics, but not triclosan, are negatively associated with urinary enterolactone; further study of triclosan exposure and enterolactone production may be needed to better understand positive associations among women. age | body mass index | diet | race | sex | socioeconomic status Anti-Bacterial Agents | Lincomycin | Macrolides | Quinolones | Sulfonamides | Triclosan Study subjects United States urine 2,3-bis(3'-hydroxybenzyl)butyrolactone | Triclosan Details
47. Jelaković B, et al. (2012). In summary, we provide molecular epidemiologic evidence that supports strongly the hypothesis that, in genetically susceptible individuals, dietary exposure to aristolochic acid is causally related to endemic (Balkan) nephropathy and to the carcinomas of the upper urinary tract associated with this disease. diet aristolochic acid I Subjects with disease:Balkan Nephropathy | Subjects with disease:Urologic Neoplasms Bosnia and Herzegovina|Croatia|
Serbia
TP53 Details Balkan Nephropathy | Urologic Neoplasms
48. Harrison RM, et al. (2004). American Cancer Society Study While many uncertainties remain, it appears plausible that known chemical carcinogens are responsible for the lung cancers attributed to particulate matter 2.5 exposure in the extended American Cancer Society Cohort Study. Arsenic | Benzo(a)pyrene | Chromium | Nickel Study subjects United States Arsenic | Benzo(a)pyrene | Chromium | Nickel Details Lung Neoplasms
49. Rosado JL, et al. (2007). Children living in an area contaminated with both arsenic and lead showed that arsenic contamination can affect children's cognitive development, independent of any effect of lead. sex | socioeconomic status Arsenic | Copper | Lead | Zinc | zinc protoporphyrin Children Mexico blood | urine Arsenic | Copper | Lead | Zinc | zinc protoporphyrin Details cognition
50. Hall MN, et al. (2009). In summary, among this group of Bangladeshi adults with a high prevalence of cobalamin deficiency, cobalamin appeared to facilitate the methylation of inorganic arsenic to monomethylarsonic acid, particularly among women and among folate sufficient individuals. Arsenic | Creatinine | Folic Acid | Homocysteine | Vitamin B 12 Study subjects Bangladesh plasma | urine | water Arsenic | Creatinine | Folic Acid | Homocysteine | Vitamin B 12 Details
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