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Chemical Proinsulin

Name Proinsulin
CAS Type 1 Name Proinsulin
CAS Registry Number 9035-68-1
Definition A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
Top Interacting
Genes
MeSH® ID D011384
External Links

Top ↑ Ancestors

1. ChemicalsHormones, Hormone Substitutes, and Hormone Antagonists Has associated genes Has associated diseases Has associated exposure references Hormones Has associated genes Has associated diseases Has associated exposure references Peptide Hormones Has associated genes Has associated diseases Has associated exposure references Pancreatic Hormones Has associated genes Has associated diseases Insulins Has associated genes Has associated diseases Proinsulin Has associated genes Has associated diseases
2. ChemicalsAmino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated exposure references Peptides Has associated genes Has associated diseases Has associated exposure references Peptide Hormones Has associated genes Has associated diseases Has associated exposure references Pancreatic Hormones Has associated genes Has associated diseases Insulins Has associated genes Has associated diseases Proinsulin Has associated genes Has associated diseases

Top ↑ Descendants

Proinsulin Has associated genes Has associated diseases
  9-fluorenylmethoxycarbonyl-arginyl-glycyl-isoleucyl-valyl-glutamyl-glutaminyl-cysteinyl-cysteinyl-threonyl-serine
  (A-C-B) human proinsulin
View node C-Peptide Has associated genes Has associated diseases
  des(1-21)preproinsulin
View node Insulin Has associated diseases
  methionyl-lysylproinsulin
  miniproinsulin
  N-(epsilon29),N-(epsilon59)-bis(methylsulfonylethoxycarbonyl)proinsulin
  proinsulin (46-70)
  proinsulin, des-(23-63)-
  proinsulin, des(31,32)-
  proinsulin, des(Lys(64),Arg(65))
  proinsulin-E. coli tryptophan E chimeric polypeptide