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Chemical Pyridones

1–50 of 178 results.
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1. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of phosphatidylinositol 3-kinase activity 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of phosphatidylinositol 3-kinase activity 1: Homo sapiens Liver | Cell Line, Tumor 1 gene: PTEN 1
2. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of phosphatidylinositol 3-kinase activity 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of phosphatidylinositol 3-kinase activity 1: Homo sapiens Hep G2 Cells 1 gene: PTEN 1
3. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of cell cycle arrest 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of cell cycle arrest 1: Homo sapiens Liver | Cell Line, Tumor   1
4. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of cell cycle arrest 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of cell cycle arrest 1: Homo sapiens Hep G2 Cells   1
5. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cell proliferation 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cell proliferation 1: Homo sapiens Hep G2 Cells
3 genes: CDKN1B | PTEN | STAT3
1
6. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cell proliferation 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cell proliferation 1: Homo sapiens Liver | Cell Line, Tumor
3 genes: CDKN1B | PTEN | STAT3
1
7. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process 1: Homo sapiens Liver | Cell Line, Tumor
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
8. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process 1: Homo sapiens Hep G2 Cells
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
9. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one activation of cysteine-type endopeptidase activity involved in apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased activation of cysteine-type endopeptidase activity involved in apoptotic process 1: Homo sapiens Liver | Cell Line, Tumor
2 genes: CASP3 | CASP9
1
10. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one activation of cysteine-type endopeptidase activity involved in apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased activation of cysteine-type endopeptidase activity involved in apoptotic process 1: Homo sapiens Hep G2 Cells
2 genes: CASP3 | CASP9
1
11. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process] 1: Homo sapiens Liver | Cell Line, Tumor
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
12. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process] 1: Homo sapiens Hep G2 Cells
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
13. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of intrinsic apoptotic signaling pathway 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of intrinsic apoptotic signaling pathway 1: Homo sapiens Liver | Cell Line, Tumor   1
14. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of intrinsic apoptotic signaling pathway 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of intrinsic apoptotic signaling pathway 1: Homo sapiens Hep G2 Cells   1
15. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one tube formation 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in decreased tube formation 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured 1 gene: VEGFA 1
16. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cell migration 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cell migration 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured 1 gene: PTEN 1
17. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of cell cycle arrest 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of cell cycle arrest 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
18. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of tyrosine phosphorylation of STAT protein 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of tyrosine phosphorylation of STAT protein 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
19. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cellular response to vascular endothelial growth factor stimulus 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cellular response to vascular endothelial growth factor stimulus 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
20. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of angiogenesis 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of angiogenesis 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
21. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of angiogenesis 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of angiogenesis 1: Homo sapiens Hep G2 Cells   1
22. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one cell proliferation Vemurafenib [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased susceptibility to Vemurafenib] which results in decreased cell proliferation 1: Homo sapiens Skin | Cell Line, Tumor
4 genes: AKT1 | PTEN | STAT3 | VEGFA
1
23. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one apoptotic process Vemurafenib [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased susceptibility to Vemurafenib] which results in increased apoptotic process 1: Homo sapiens Skin | Cell Line, Tumor
5 genes: AKT1 | CASP3 | CASP9 | PARP1 | PTEN
1
24. 2-hydrazinopyridine regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter 2-hydrazinopyridine results in decreased regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter 1: Homo sapiens Keratinocytes | Cell Line   1
25. 2-hydrazinopyridine regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter 2-hydrazinopyridine results in decreased regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter 1: Mus musculus 3T3-L1 Cells   1
26. 2-hydrazinopyridine regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter sodium arsenite 2-hydrazinopyridine inhibits the reaction [sodium arsenite results in increased regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter] 1: Homo sapiens Keratinocytes | Cell Line   1
27. 2-hydrazinopyridine regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter sodium arsenite 2-hydrazinopyridine inhibits the reaction [sodium arsenite results in increased regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter] 1: Mus musculus 3T3-L1 Cells   1
28. 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one positive regulation of eosinophil chemotaxis IL4 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [IL4 protein results in increased positive regulation of eosinophil chemotaxis] 1: Homo sapiens Eosinophils | Cell Line, Tumor 1 gene: IL4 1
29. 3,5,6-trichloro-2-pyridinol cell proliferation 3,5,6-trichloro-2-pyridinol affects cell proliferation 1: Mus musculus Embryonic Stem Cells | Cell Line
3 genes: ACHE | GLUL | NANOG
1
30. 3,5,6-trichloro-2-pyridinol flagellated sperm motility 3,5,6-trichloro-2-pyridinol results in decreased flagellated sperm motility 1: Homo sapiens Spermatozoa   1
31. 3,5,6-trichloro-2-pyridinol spermatogenesis 3,5,6-trichloro-2-pyridinol results in decreased spermatogenesis 1: Homo sapiens Spermatozoa   1
32. 3,5,6-trichloro-2-pyridinol xenobiotic metabolic process Pesticides [Pesticides results in increased xenobiotic metabolic process] which results in increased abundance of 3,5,6-trichloro-2-pyridinol 1: Homo sapiens Urine
2 genes: CYP2C19 | CYP3A4
1
33. apixaban negative regulation of hemostasis APC apixaban promotes the reaction [APC gene mutant form results in increased negative regulation of hemostasis] 1: Mus musculus Gastrointestinal Tract   1
34. atpenin A5 vasodilation atpenin A5 results in increased vasodilation 1: Mus musculus Muscles | Mesenteric Arteries   1
35. atpenin A5 vasodilation Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [atpenin A5 results in increased vasodilation] 1: Mus musculus Muscles | Mesenteric Arteries   1
36. atpenin A5 vasodilation 4-Aminopyridine | Ryanodine [Ryanodine co-treated with 4-Aminopyridine] inhibits the reaction [atpenin A5 results in increased vasodilation] 1: Mus musculus Muscles | Mesenteric Arteries   1
37. atpenin A5 vasodilation Diazoxide atpenin A5 inhibits the reaction [Diazoxide results in increased vasodilation] 1: Mus musculus Muscles | Mesenteric Arteries   1
38. atpenin A5 positive regulation of mitochondrial membrane potential atpenin A5 results in decreased positive regulation of mitochondrial membrane potential 1: Mus musculus RAW 264.7 Cells 1 gene: AKT1 1
39. atpenin A5 mitochondrial electron transport, succinate to ubiquinone atpenin A5 results in decreased mitochondrial electron transport, succinate to ubiquinone 1: Mus musculus RAW 264.7 Cells   1
40. atpenin A5 reactive oxygen species biosynthetic process TNF atpenin A5 inhibits the reaction [TNF protein results in increased reactive oxygen species biosynthetic process] 1: Mus musculus Hepatocytes | Cell Line, Tumor   1
41. Ciclopirox regulation of mitochondrial membrane potential Peroxynitrous Acid Ciclopirox inhibits the reaction [Peroxynitrous Acid results in decreased regulation of mitochondrial membrane potential] 1: Rattus norvegicus Astrocytes | Cells, Cultured   1
42. Ciclopirox cell death linsidomine Ciclopirox inhibits the reaction [linsidomine results in increased cell death] 1: Rattus norvegicus Astrocytes | Cells, Cultured 1 gene: HMOX1 1
43. Ciclopirox regulation of mitochondrial membrane potential linsidomine Ciclopirox inhibits the reaction [linsidomine results in decreased regulation of mitochondrial membrane potential] 1: Rattus norvegicus Astrocytes | Cells, Cultured   1
44. Ciclopirox cell proliferation Ciclopirox results in decreased cell proliferation 1: Homo sapiens Granulocyte Precursor Cells | Tumor Cells, Cultured
2 genes: AR | MAP2K1
1
45. Ciclopirox cell proliferation Ciclopirox results in decreased cell proliferation 1: Homo sapiens Jurkat Cells
2 genes: AR | MAP2K1
1
46. Ciclopirox cell proliferation Ciclopirox results in decreased cell proliferation 1: Homo sapiens Bone Marrow | Cell Line, Tumor
2 genes: AR | MAP2K1
1
47. Ciclopirox cell proliferation Ciclopirox results in decreased cell proliferation 1: Homo sapiens U937 Cells
2 genes: AR | MAP2K1
1
48. Ciclopirox cell proliferation Ciclopirox results in decreased cell proliferation 1: Homo sapiens HCT116 Cells
2 genes: AR | MAP2K1
1
49. Ciclopirox cell proliferation Ciclopirox results in decreased cell proliferation 1: Homo sapiens HT29 Cells
2 genes: AR | MAP2K1
1
50. Ciclopirox cell proliferation Ciclopirox results in decreased cell proliferation 1: Homo sapiens Blood Cells
2 genes: AR | MAP2K1
1
1–50 of 178 results.