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Chemical Pyrrolizidine Alkaloids

Name Pyrrolizidine Alkaloids
Equivalent Terms Alkaloids, Pyrrolizidine | Alkaloids, Senecio | Senecio Alkaloids
Definition A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
Top Interacting
Genes
MeSH® ID D011763
External Links

Top ↑ Ancestors

1. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Alkaloids Has associated genes Has associated diseases Has associated exposure references Pyrrolizidine Alkaloids Has associated genes Has associated diseases
2. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 2-Ring Has associated genes Has associated diseases Has associated exposure references Pyrrolizidine Alkaloids Has associated genes Has associated diseases

Top ↑ Descendants

Pyrrolizidine Alkaloids Has associated genes Has associated diseases
  1'-(4-methoxyphenyl)-2'-(furan-2-carbonyl)-1',2',5',6',7',7a'-hexahydrospiro(indoline-3,3'-pyrrolizin)-2-one
  19-hydroxysenecionine
  1-aminopyrrolizidine
  1-epi-alexine
  3-(3,4-dihydroxyphenyl)-8H-thieno(2,3-b)pyrrolizin-8-one
  3-(3-hydroxy-4-methoxyphenyl)-8H-thieno(2,3-b)pyrrolizin-8-one
  (3H-pyrrolizin-7-yl)methanol
  3-hydroxy-cis-nemorensic acid
  4-hydroxy-nemorensic acid
  5-acetamidomethyl-3-hydroxymethyl-1,6,7-trihydroxypyrrolizidine
  5-chlorobohemamine C
  6-azido hyacinthacine A2
  7a-epi-hyacinthacine A1
  7-O-9-O-dibutyroyl-(9,9-2H2)-retronecine
  9-angeloylhastanecine
  acetylanonamine
  acetylnorloline
  adonifoline
  amphorogynine A
  amphorogynine D
  anacrotine
  anonamine
  asmachilca
  australine
  axillarine
  BE 54238A
  BE 54238B
  bistellettazine A
  bistellettazine B
  bistellettazine C
  bohemamine
  bohemamine B
  bohemamine C
  chestnutamide
  clivorine Has associated genes Has associated diseases
  cremastrine
  croalbinecine
  cyngal
  danaidone
  deacetylclivorine
  dehydroanacrotine
  dehydroretrorsine
  dehydrosupinidine
  diplacin
  disenecioyldehydroretronecine
  echivulgarine
  epiaustraline
  erucifoline
  fulvine
  glutathione-dehydro-retronecine conjugate
  glutathione-jacobine conjugate
  hastanecine
  heliotridane
  heliotrine Has associated genes Has associated diseases
  heliotrine N-oxide
  hexahydro-1H-pyrrolizin-1-ylmethyl 1-methyl-1H-indole-3-carboxylate
  (hexahydro-5-oxo-1H-pyrrolizinyl-1-yl)acetic acid
  hyacinthacine A1
  hyacinthacine A2
  hyacinthacine A3
  hyacinthacine B3
  hyacinthacine B4
  hyacinthacine B5
  hyacinthacine B7
  hyacinthacine C5
  hydroxydanaidal
  hydroxysenkirkine
  indicine
  indicine-N-oxide
  intermedine
  isatidine
  isoline Has associated genes Has associated diseases
  isoretronecanol
  jacobine
  lasiocarpine
  latifoline
  lindelofine-N-oxide
  megalanthonine
View node Monocrotaline Has associated genes Has associated diseases
  N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide Has associated genes Has associated diseases
  N-4-phenylphenacylheliotridanium
  N-acetylcysteine-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine
  nemorensic acid
  NP 25302
  osyrisine
  otonecine
  otosenine
  penibruguieramine A
  penicinoline
  PF 1018
  platyphylline Has associated genes Has associated diseases
  pyrrolam A
  retronecine
  retrorsine Has associated genes Has associated diseases
  riddelliine Has associated genes Has associated diseases
  riddelliine N-oxide
  rosmarinecine
  sarracine
  senaetnine
  Senecion
  senecionine Has associated genes Has associated diseases
  senecionine N-oxide
  seneciphylline
  seneciphyllinine
  senesionine
  senkirkine Has associated genes Has associated diseases
  spiropyrrolizidine oxime 222
  spiropyrrolizidine oxime 236
  spithioneine A
  spithioneine B
  strigosine
  supinidine
  swazine
  symlandine
  symphytine
  synthanecine A-bis(N-ethylcarbamate)
  talarotoxin
  thesinine-O-4'-alpha-rhamnoside
  trachelanthamidine
  turneforcidine
  UCS 1025A
  UCS1025B
  xenovenine