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Chemical Sapogenins

1–50 of 103 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole regulation of mitochondrial membrane potential 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in decreased regulation of mitochondrial membrane potential 1: Homo sapiens Cell Line, Tumor | Pancreas 1 gene: PRKN 1
2. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process Mercaptoethanol Mercaptoethanol inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process] 1: Homo sapiens Cell Line, Tumor | Pancreas
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
3. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process 1: Homo sapiens Cell Line, Tumor | Pancreas
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
4. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process arsenic trioxide arsenic trioxide promotes the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process] 1: Homo sapiens Cells, Cultured
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
5. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process Bortezomib [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole co-treated with Bortezomib] results in increased apoptotic process 1: Homo sapiens Blood | Tumor Cells, Cultured
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
6. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process BCL2 | Bortezomib [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole co-treated with Bortezomib] inhibits the reaction [BCL2 protein results in decreased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
7. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process 1: Homo sapiens Cells, Cultured
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
8. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process Glutathione Glutathione inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process] 1: Homo sapiens Cell Line, Tumor | Pancreas
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
9. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process 1: Homo sapiens Blood | Cell Line, Tumor
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
10. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole cell proliferation 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in decreased cell proliferation 1: Homo sapiens Cell Line, Tumor | Pancreas
10 genes: AR | CREG1 | ENTPD5 | GNAT1 | MYC | NRG1 | POLR3G | TNF | TXNRD1 | UCHL1
1
11. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process Bortezomib Bortezomib promotes the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
12. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole regulation of mitochondrial membrane potential Mercaptoethanol Mercaptoethanol inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased regulation of mitochondrial membrane potential] 1: Homo sapiens Cell Line, Tumor | Pancreas 1 gene: PRKN 1
13. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole regulation of mitochondrial membrane potential Bortezomib [Bortezomib co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in decreased regulation of mitochondrial membrane potential 1: Homo sapiens Blood | Cell Line, Tumor 1 gene: PRKN 1
14. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole regulation of mitochondrial membrane potential Dithiothreitol Dithiothreitol inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased regulation of mitochondrial membrane potential] 1: Homo sapiens Cell Line, Tumor | Pancreas 1 gene: PRKN 1
15. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process 1: Homo sapiens Bone Marrow | Stromal Cells
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
16. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole regulation of mitochondrial membrane potential Glutathione Glutathione inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased regulation of mitochondrial membrane potential] 1: Homo sapiens Cell Line, Tumor | Pancreas 1 gene: PRKN 1
17. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole apoptotic process Dithiothreitol Dithiothreitol inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased apoptotic process] 1: Homo sapiens Cell Line, Tumor | Pancreas
13 genes: CASP3 | CASP8 | CASP9 | DIABLO | EGLN3 | HMOX1 | HTATIP2 | IER3 | IFNG | PLK3 | RASSF6 | TNF | TRIB3
1
18. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid results in increased positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1: Homo sapiens Esophagus | Cell Line, Tumor   1
19. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid apoptotic process 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid results in increased apoptotic process 1: Homo sapiens Blood | Cell Line, Tumor 1 gene: HMOX1 1
20. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid apoptotic process 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid results in increased apoptotic process 1: Homo sapiens Cell Line, Tumor 1 gene: HMOX1 1
21. 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide positive regulation of hepatic stellate cell activation Lipopolysaccharides 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [Lipopolysaccharides results in increased positive regulation of hepatic stellate cell activation] 1: Homo sapiens Liver | Hepatic Stellate Cells | Cell Line 1 gene: ACTA2 1
22. 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide glutathione biosynthetic process 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide results in increased glutathione biosynthetic process 1: Rattus norvegicus Mesencephalon | Dopaminergic Neurons | Cell Line
2 genes: GCLC | GCLM
1
23. 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide microglial cell activation 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased microglial cell activation] 1: Mus musculus Microglia | Cells 1 gene: TLR4 1
24. 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide neuron death 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased neuron death] 1: Mus musculus Substantia Nigra | Neurons   1
25. (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide neuron death 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased neuron death] 1: Mus musculus Substantia Nigra | Neurons   1
26. (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide microglial cell activation 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased microglial cell activation] 1: Mus musculus Microglia | Cells   1
27. (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide glutathione biosynthetic process (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide results in increased glutathione biosynthetic process 1: Rattus norvegicus Mesencephalon | Dopaminergic Neurons | Cell Line
2 genes: GCLC | GCLM
1
28. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of cell death GSK3B GSK3B protein mutant form inhibits the reaction [methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased positive regulation of cell death] 1: Homo sapiens Prostate | Cell Line, Tumor 1 gene: UCP2 1
29. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of interleukin-17 secretion Lipopolysaccharides methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased positive regulation of interleukin-17 secretion] 1: Mus musculus Macrophages   1
30. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of vascular endothelial growth factor production Lipopolysaccharides methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased positive regulation of vascular endothelial growth factor production] 2: Homo sapiens | Mus musculus Macrophages   1
31. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate regulation of cell size Dietary Fats methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats affects regulation of cell size] 1: Mus musculus Adipose Tissue | Adipocytes 1 gene: STAT3 1
32. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate glutathione metabolic process methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate affects glutathione metabolic process 1: Homo sapiens Retina | Cell Line, Tumor
2 genes: GCLC | GCLM
1
33. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate regulation of macrophage activation methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate affects regulation of macrophage activation 2: Homo sapiens | Mus musculus Macrophages   1
34. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate glutathione metabolic process Glutathione [methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate affects glutathione metabolic process] which results in decreased abundance of Glutathione 1: Homo sapiens Prostate | Cell Line, Tumor
2 genes: GCLC | GCLM
1
35. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate cell proliferation Dietary Fats methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased cell proliferation] 1: Mus musculus Adipose Tissue | Adipocytes
8 genes: ADRA1B | AKT1 | AURKB | CHRM1 | GSK3B | STAT3 | TNF | VEGFA
1
36. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of cell death Cisplatin methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Cisplatin results in increased positive regulation of cell death] 1: Homo sapiens Kidney Tubules, Proximal | Cells, Cultured 1 gene: UCP2 1
37. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of interleukin-10 secretion Lipopolysaccharides methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased positive regulation of interleukin-10 secretion] 2: Homo sapiens | Mus musculus Macrophages   1
38. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate glutathione metabolic process methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate affects glutathione metabolic process 1: Homo sapiens Prostate | Cell Line, Tumor
2 genes: GCLC | GCLM
1
39. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate glutathione biosynthetic process tert-Butylhydroperoxide methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [tert-Butylhydroperoxide results in decreased glutathione biosynthetic process] 1: Homo sapiens Bronchi | Epithelial Cells
2 genes: GCLC | GCLM
1
40. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate cell migration Dietary Fats methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased cell migration] 1: Mus musculus Kidney | Macrophages
2 genes: GSK3B | VEGFA
1
41. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of cell death methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased positive regulation of cell death 1: Homo sapiens Retina | Cell Line, Tumor 1 gene: UCP2 1
42. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate glutathione metabolic process Glutathione [methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate affects glutathione metabolic process] which results in decreased abundance of Glutathione 1: Homo sapiens Retina | Cell Line, Tumor
2 genes: GCLC | GCLM
1
43. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate regulation of nucleus size methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate affects regulation of nucleus size 1: Homo sapiens Lung | Epithelial Cells | Cell Line   1
44. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate mitochondrion organization methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased mitochondrion organization 1: Homo sapiens Lung | Epithelial Cells | Cell Line 1 gene: PARP1 1
45. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate regulation of membrane permeability methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate affects regulation of membrane permeability 1: Homo sapiens Lung | Epithelial Cells | Cell Line   1
46. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate regulation of NIK/NF-kappaB signaling IL1B methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [IL1B protein results in increased regulation of NIK/NF-kappaB signaling] 1: Homo sapiens Bronchi | Epithelial Cells | Cell Line 1 gene: NFKBIA 1
47. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of tumor necrosis factor production Lipopolysaccharides methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate promotes the reaction [Lipopolysaccharides results in increased positive regulation of tumor necrosis factor production] 2: Homo sapiens | Mus musculus Macrophages
7 genes: CCL2 | CCL3 | CCL4 | CCR5 | IFNG | JAK2 | LEP
1
48. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate positive regulation of interleukin-6 secretion Lipopolysaccharides methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate promotes the reaction [Lipopolysaccharides results in increased positive regulation of interleukin-6 secretion] 2: Homo sapiens | Mus musculus Macrophages 1 gene: IL17A 1
49. methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate cell migration Dietary Fats methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased cell migration] 1: Mus musculus Heart | Macrophages
2 genes: GSK3B | VEGFA
1
50. methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate autophagy methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate results in increased autophagy 1: Homo sapiens Breast | Cell Line, Tumor
2 genes: BECN1 | TP53
1
1–50 of 103 results.