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Chemical Spiro Compounds

1–50 of 180 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one cell proliferation 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased cell proliferation 1: Homo sapiens Brain | Cell Line, Tumor
5 genes: BUB1 | EGFR | MYC | RAC1 | SKP2
1
2. 13,19-didesmethyl spirolide C regulation of skeletal muscle acetylcholine-gated channel clustering 13,19-didesmethyl spirolide C affects regulation of skeletal muscle acetylcholine-gated channel clustering 1: Homo sapiens Embryo, Nonmammalian   1
3. 13-desmethylspirolide C regulation of skeletal muscle acetylcholine-gated channel clustering 13-desmethylspirolide C affects regulation of skeletal muscle acetylcholine-gated channel clustering 1: Homo sapiens Embryo, Nonmammalian   1
4. 2',7'-dichlorofluorescein cell redox homeostasis Quercetin [Quercetin results in increased cell redox homeostasis] which results in decreased oxidation of 2',7'-dichlorofluorescein 1: Homo sapiens Hep G2 Cells   1
5. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 1: Homo sapiens HEK293 Cells   1
6. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 3: Canis lupus familiaris | Mus musculus | Rattus norvegicus     1
7. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process Naloxone | OPRM1 Naloxone inhibits the reaction [[OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process] 1: Homo sapiens HEK293 Cells   1
8. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid triglyceride biosynthetic process (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid results in decreased triglyceride biosynthetic process 2: Macaca fascicularis | Rattus norvegicus Plasma   1
9. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid cholesterol biosynthetic process (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid results in decreased cholesterol biosynthetic process 1: Rattus norvegicus Plasma   1
10. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid phospholipid biosynthetic process (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid results in decreased phospholipid biosynthetic process 2: Macaca fascicularis | Rattus norvegicus Plasma   1
11. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid L-aspartate:2-oxoglutarate aminotransferase activity (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid results in increased L-aspartate:2-oxoglutarate aminotransferase activity 1: Macaca fascicularis Plasma   1
12. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid lipid droplet formation (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid results in increased lipid droplet formation 1: Macaca fascicularis Jejunum | Epithelial Cells   1
13. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid lipid droplet formation (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid results in increased lipid droplet formation 1: Macaca fascicularis Jejunum | Mucous Membrane   1
14. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid L-aspartate:2-oxoglutarate aminotransferase activity Corn Oil [Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased L-aspartate:2-oxoglutarate aminotransferase activity 2: Canis lupus familiaris | Rattus norvegicus Plasma   1
15. (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid L-aspartate:2-oxoglutarate aminotransferase activity Corn Oil | Orlistat Orlistat inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased L-aspartate:2-oxoglutarate aminotransferase activity] 1: Canis lupus familiaris Plasma   1
16. 5(6)-carboxy-2',7'-dichlorofluorescein methotrexate transport 5(6)-carboxy-2',7'-dichlorofluorescein results in increased methotrexate transport 1: Rattus norvegicus Intestines   1
17. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport Emodin [Emodin results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Hepatocytes | Cells, Cultured 1 gene: ABCC3 1
18. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport Emodin [Emodin results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Bile 1 gene: ABCC3 1
19. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport chrysophanic acid [chrysophanic acid results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Hepatocytes | Cells, Cultured 1 gene: ABCC3 1
20. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport chrysophanic acid [chrysophanic acid results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Bile 1 gene: ABCC3 1
21. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport physcione [physcione results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Hepatocytes | Cells, Cultured 1 gene: ABCC3 1
22. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport physcione [physcione results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Bile 1 gene: ABCC3 1
23. 8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione regulation of feeding behavior 1-(3-chlorophenyl)piperazine | Corticosterone 8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione inhibits the reaction [1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone affects regulation of feeding behavior]] 1: Mus musculus     1
24. acylfulvene cell death PTGR1 [PTGR1 protein results in increased metabolism of acylfulvene] which results in increased cell death     1
25. acylfulvene DNA damage response, detection of DNA damage PTGR1 [PTGR1 protein results in increased metabolism of acylfulvene] which results in increased DNA damage response, detection of DNA damage     1
26. acylfulvene RNA biosynthetic process acylfulvene results in decreased RNA biosynthetic process 1: Homo sapiens Fibroblasts | Cell Line   1
27. acylfulvene RNA biosynthetic process ERCC6 ERCC6 protein affects the reaction [acylfulvene results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
28. acylfulvene RNA biosynthetic process XPA XPA protein affects the reaction [acylfulvene results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
29. acylfulvene RNA biosynthetic process XPC XPC protein affects the reaction [acylfulvene results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
30. acylfulvene RNA biosynthetic process acylfulvene analog results in decreased RNA biosynthetic process 1: Homo sapiens Fibroblasts | Cell Line   1
31. acylfulvene RNA biosynthetic process ERCC6 ERCC6 protein affects the reaction [acylfulvene analog results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
32. acylfulvene RNA biosynthetic process XPA XPA protein affects the reaction [acylfulvene analog results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
33. acylfulvene RNA biosynthetic process XPC XPC protein affects the reaction [acylfulvene analog results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
34. aplaviroc positive regulation of cytosolic calcium ion concentration CCL3 aplaviroc inhibits the reaction [CCL3 protein results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens HEK293 Cells
2 genes: CCL3 | CCR5
1
35. aplaviroc positive regulation of cytosolic calcium ion concentration CCL5 aplaviroc inhibits the reaction [CCL5 protein results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens HEK293 Cells
2 genes: CCL3 | CCR5
1
36. AR-R 17779 cell proliferation AR-R 17779 results in increased cell proliferation 1: Homo sapiens Cell Line, Tumor   1
37. AR-R 17779 cell proliferation methyllycaconitine methyllycaconitine inhibits the reaction [AR-R 17779 results in increased cell proliferation] 1: Homo sapiens Cell Line, Tumor   1
38. AR-R 17779 cell proliferation Mecamylamine Mecamylamine inhibits the reaction [AR-R 17779 results in increased cell proliferation] 1: Homo sapiens Cell Line, Tumor   1
39. azaspiracid regulation of blood pressure azaspiracid affects regulation of blood pressure 1: Rattus norvegicus Arteries   1
40. azaspiracid cardiac muscle tissue development azaspiracid affects cardiac muscle tissue development 1: Rattus norvegicus Myocardium   1
41. azaspirane apoptotic process Dexamethasone Dexamethasone promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
42. azaspirane apoptotic process Melphalan Melphalan promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
43. azaspirane apoptotic process Doxorubicin Doxorubicin promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
44. azaspirane apoptotic process Arsenic Trioxide Arsenic Trioxide promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
45. azaspirane apoptotic process azaspirane results in increased apoptotic process 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
46. azaspirane cell proliferation azaspirane results in increased cell proliferation 1: Homo sapiens Blood | Cell Line, Tumor 1 gene: STAT3 1
47. azaspirane apoptotic DNA fragmentation azaspirane results in increased apoptotic DNA fragmentation 1: Homo sapiens Blood | Cell Line, Tumor 1 gene: CASP3 1
48. azaspirane apoptotic DNA fragmentation azaspirane results in increased apoptotic DNA fragmentation 1: Homo sapiens Cells 1 gene: CASP3 1
49. azaspirane apoptotic process azaspirane results in increased apoptotic process 1: Homo sapiens Cells
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
50. azaspirane cell proliferation azaspirane results in decreased cell proliferation 1: Homo sapiens Cells 1 gene: STAT3 1
1–50 of 180 results.