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Chemical Spiro Compounds

1–50 of 153 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one cell proliferation 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased cell proliferation 1: Homo sapiens Brain | Cell Line, Tumor
5 genes: BUB1 | EGFR | MYC | RAC1 | SKP2
1
2. 13,19-didesmethyl spirolide C regulation of skeletal muscle acetylcholine-gated channel clustering 13,19-didesmethyl spirolide C affects regulation of skeletal muscle acetylcholine-gated channel clustering 1: Homo sapiens Embryo, Nonmammalian   1
3. 13-desmethylspirolide C regulation of skeletal muscle acetylcholine-gated channel clustering 13-desmethylspirolide C affects regulation of skeletal muscle acetylcholine-gated channel clustering 1: Homo sapiens Embryo, Nonmammalian   1
4. 2',7'-dichlorofluorescein cell redox homeostasis Quercetin [Quercetin results in increased cell redox homeostasis] which results in decreased oxidation of 2',7'-dichlorofluorescein 1: Homo sapiens Hep G2 Cells   1
5. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process Naloxone | OPRM1 Naloxone inhibits the reaction [[OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process] 1: Homo sapiens HEK293 Cells   1
6. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 3: Canis lupus familiaris | Mus musculus | Rattus norvegicus     1
7. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 1: Homo sapiens HEK293 Cells   1
8. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport physcione [physcione results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Bile 1 gene: ABCC3 1
9. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport physcione [physcione results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Hepatocytes | Cells, Cultured 1 gene: ABCC3 1
10. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport chrysophanic acid [chrysophanic acid results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Hepatocytes | Cells, Cultured 1 gene: ABCC3 1
11. 5(6)-carboxy-2',7'-dichlorofluorescein methotrexate transport 5(6)-carboxy-2',7'-dichlorofluorescein results in increased methotrexate transport 1: Rattus norvegicus Intestines   1
12. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport Emodin [Emodin results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Bile 1 gene: ABCC3 1
13. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport chrysophanic acid [chrysophanic acid results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Bile 1 gene: ABCC3 1
14. 5(6)-carboxy-2',7'-dichlorofluorescein bile acid and bile salt transport Emodin [Emodin results in decreased bile acid and bile salt transport] which results in increased abundance of 5(6)-carboxy-2',7'-dichlorofluorescein 1: Rattus norvegicus Hepatocytes | Cells, Cultured 1 gene: ABCC3 1
15. 8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione regulation of feeding behavior 1-(3-chlorophenyl)piperazine | Corticosterone 8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione inhibits the reaction [1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone affects regulation of feeding behavior]] 1: Mus musculus     1
16. acylfulvene RNA biosynthetic process XPC XPC protein affects the reaction [acylfulvene analog results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
17. acylfulvene cell death PTGR1 [PTGR1 protein results in increased metabolism of acylfulvene] which results in increased cell death     1
18. acylfulvene RNA biosynthetic process ERCC6 ERCC6 protein affects the reaction [acylfulvene results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
19. acylfulvene RNA biosynthetic process XPC XPC protein affects the reaction [acylfulvene results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
20. acylfulvene RNA biosynthetic process acylfulvene results in decreased RNA biosynthetic process 1: Homo sapiens Fibroblasts | Cell Line   1
21. acylfulvene RNA biosynthetic process acylfulvene analog results in decreased RNA biosynthetic process 1: Homo sapiens Fibroblasts | Cell Line   1
22. acylfulvene DNA damage response, detection of DNA damage PTGR1 [PTGR1 protein results in increased metabolism of acylfulvene] which results in increased DNA damage response, detection of DNA damage     1
23. acylfulvene RNA biosynthetic process XPA XPA protein affects the reaction [acylfulvene analog results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
24. acylfulvene RNA biosynthetic process ERCC6 ERCC6 protein affects the reaction [acylfulvene analog results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
25. acylfulvene RNA biosynthetic process XPA XPA protein affects the reaction [acylfulvene results in decreased RNA biosynthetic process] 1: Homo sapiens Fibroblasts | Cell Line   1
26. aplaviroc positive regulation of cytosolic calcium ion concentration CCL5 aplaviroc inhibits the reaction [CCL5 protein results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens HEK293 Cells
2 genes: CCL3 | CCR5
1
27. aplaviroc positive regulation of cytosolic calcium ion concentration CCL3 aplaviroc inhibits the reaction [CCL3 protein results in increased positive regulation of cytosolic calcium ion concentration] 1: Homo sapiens HEK293 Cells
2 genes: CCL3 | CCR5
1
28. AR-R 17779 cell proliferation Mecamylamine Mecamylamine inhibits the reaction [AR-R 17779 results in increased cell proliferation] 1: Homo sapiens Cell Line, Tumor   1
29. AR-R 17779 cell proliferation methyllycaconitine methyllycaconitine inhibits the reaction [AR-R 17779 results in increased cell proliferation] 1: Homo sapiens Cell Line, Tumor   1
30. AR-R 17779 cell proliferation AR-R 17779 results in increased cell proliferation 1: Homo sapiens Cell Line, Tumor   1
31. azaspiracid regulation of blood pressure azaspiracid affects regulation of blood pressure 1: Rattus norvegicus Arteries   1
32. azaspiracid cardiac muscle tissue development azaspiracid affects cardiac muscle tissue development 1: Rattus norvegicus Myocardium   1
33. azaspirane cell proliferation azaspirane results in increased cell proliferation 1: Homo sapiens Blood | Cell Line, Tumor
2 genes: STAT3 | TNF
1
34. azaspirane apoptotic process Dexamethasone Dexamethasone promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
35. azaspirane apoptotic process arsenic trioxide arsenic trioxide promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Cells
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
36. azaspirane apoptotic process Dexamethasone Dexamethasone promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Cells
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
37. azaspirane apoptotic process azaspirane results in increased apoptotic process 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
38. azaspirane apoptotic process azaspirane results in increased apoptotic process 1: Homo sapiens Cells
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
39. azaspirane cell differentiation azaspirane results in decreased cell differentiation 1: Homo sapiens Umbilical Veins | Endothelial Cells
2 genes: JAK2 | MCL1
1
40. azaspirane apoptotic process arsenic trioxide arsenic trioxide promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
41. azaspirane cell proliferation azaspirane results in decreased cell proliferation 1: Homo sapiens Cells
2 genes: STAT3 | TNF
1
42. azaspirane apoptotic DNA fragmentation azaspirane results in increased apoptotic DNA fragmentation 1: Homo sapiens Cells 1 gene: CASP3 1
43. azaspirane apoptotic DNA fragmentation azaspirane results in increased apoptotic DNA fragmentation 1: Homo sapiens Blood | Cell Line, Tumor 1 gene: CASP3 1
44. azaspirane apoptotic process Melphalan Melphalan promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
45. azaspirane apoptotic process Doxorubicin Doxorubicin promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Blood | Cell Line, Tumor
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
46. azaspirane apoptotic process Doxorubicin Doxorubicin promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Cells
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
47. azaspirane apoptotic process Melphalan Melphalan promotes the reaction [azaspirane results in increased apoptotic process] 1: Homo sapiens Cells
7 genes: CASP3 | CASP8 | JAK2 | MCL1 | NFKBIA | PARP1 | TNF
1
48. binospirone mesylate regulation of blood pressure binospirone mesylate affects regulation of blood pressure 1: Rattus norvegicus Cardiovascular System   1
49. Buspirone regulation of blood pressure Buspirone affects regulation of blood pressure 1: Rattus norvegicus Cardiovascular System
3 genes: COL1A2 | POMC | SGK1
1
50. Buspirone regulation of heart rate Buspirone affects regulation of heart rate 1: Rattus norvegicus Cardiovascular System
3 genes: CALM1 | CALM2 | PRKACA
1
1–50 of 153 results.