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Chemical Spironolactone

Name Spironolactone
CAS Type 1 Name Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-
Equivalent Terms Aldactone | Aldactone A | Aquareduct | Ct, Spiro Von | Duraspiron | Espironolactona Alter | Espironolactona Mundogen | Flumach | Frumikal | Jenaspiron | NovoSpiroton | Novo Spiroton | Novo-Spiroton | Practon | SC9420 | SC 9420 | SC-9420 | Spiractin | Spirobeta | Spirogamma | Spirolactone | Spirolang | Spiro L.U.T. | Spirono Isis | Spirono-Isis | Spironone | Spirospare | Spiro Von Ct | Veroshpiron | Verospiron | Verospirone | Von Ct, Spiro
CAS Registry Number 52-01-7
Definition A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Structure Spironolactone
Top Interacting
Genes
MeSH® ID D013148
External Links

Top ↑ Ancestors

1. ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Lactones Has associated genes Has associated diseases Has associated exposure references Spironolactone Has associated genes Has associated diseases
2. ChemicalsPolycyclic Compounds Has associated genes Has associated diseases Has associated exposure references Fused-Ring Compounds Has associated genes Has associated diseases Has associated exposure references Steroids Has associated genes Has associated diseases Has associated exposure references Pregnanes Has associated genes Has associated diseases Has associated exposure references Pregnenes Has associated genes Has associated diseases Has associated exposure references Spironolactone Has associated genes Has associated diseases

Top ↑ Descendants

Spironolactone Has associated genes Has associated diseases
  3-(3-oxo-7 alpha-methylsulfonyl-6 beta,17 beta- dihydroxy-4-androsten-17 alpha-yl)propionic acid gamma-lactone
  6,6-ethylene-15,16-methylene-3-oxo-17-pregn-4-ene-2,17-carbolactone
  6,7-epoxycanrenone
  6-hydroxy-7-thiomethylspirolactone
  7alpha-(methylthio)spironolactone S-oxide
  7 alpha-thiospironolactone
  7-propyl spirolactone Has associated genes Has associated diseases
  7-thiomethylspirolactone
  8-(3-(4-fluorobenzoyl)propyl)-1-methyl-1,3,8-triazaspiro(4,5)decan-4-one
  8-(3-(4-iodobenzoyl)propyl)-1-methyl-1,3,8-triazaspiro(4,5)decan-4-one
  bupranolol, spironolactone drug combination
  buthiazide, spironolactone drug combination
  dihydroxy-6,7-dihydrocanrenone
  eplerenone Has associated genes Has associated diseases
  epoxymexrenone
  lasilacton
  mespirenone
  naphthospironone
  prorenoate potassium
  prorenone
  RU 28318
  SC 25152
  SC 26304
  SC 30822
  SC70303
  SC 8109
  spironolactone, althiazide drug combination
  spironolactone-beta-cyclodextrin complex
  spiroprop
  yaoshanenolide A
  yaoshanenolide B
  ZK 91587
  ZK 97894