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Chemical Sulindac

Name Sulindac
CAS Type 1 Name 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-
Equivalent Terms Aclin | Apo Sulin | Apo-Sulin | Arthrobid | Arthrocine | Chibret | Clinoril | Copal | Kenalin | Klinoril | MK231 | MK 231 | MK-231 | Novo Sundac | Novo-Sundac | Nu Sulindac | Nu-Sulindac | Sulindal
CAS Registry Number 38194-50-2
Definition A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Structure Sulindac
Top Interacting
Genes
MeSH® ID D013467
External Links

Top ↑ Ancestors

1. ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Hydrocarbons Has associated genes Has associated diseases Has associated exposure references Hydrocarbons, Cyclic Has associated genes Has associated diseases Has associated exposure references Hydrocarbons, Aromatic Has associated genes Has associated diseases Has associated exposure references Polycyclic Aromatic Hydrocarbons Has associated genes Has associated diseases Has associated exposure references Indenes Has associated genes Has associated diseases Has associated exposure references Sulindac Has associated genes Has associated diseases
2. ChemicalsPolycyclic Compounds Has associated genes Has associated diseases Has associated exposure references Polycyclic Aromatic Hydrocarbons Has associated genes Has associated diseases Has associated exposure references Indenes Has associated genes Has associated diseases Has associated exposure references Sulindac Has associated genes Has associated diseases

Top ↑ Descendants

Sulindac Has associated genes Has associated diseases
  2-(1-benzylidene-5-bromo-2-methyl-1H-inden-3-yl)acetic acid
  (5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide
  5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid 4-(5-thioxo-5H-1,2-dithiol-3-yl)-phenyl ester
  (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride Has associated genes Has associated diseases
  nitrosulindac
  OXT-328 Has associated genes Has associated diseases
  S-sulindac Has associated genes Has associated diseases
  sulindac derivative IND 12 Has associated genes Has associated diseases
  sulindac sulfide Has associated genes Has associated diseases
  sulindac sulfide amide
  sulindac sulfone Has associated genes Has associated diseases