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Chemical Tetanus Toxin

Name Tetanus Toxin
Equivalent Terms Clostridial Neurotoxin | Clostridium tetani Toxin | Neurotoxin, Clostridial | Tetanus Toxins | Toxin, Clostridium tetani | Toxins, Tetanus | Toxin, Tetanus
Definition Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Top Interacting
Genes
MeSH® ID D013744
External Links

Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Bacterial Toxins Has associated genes Has associated diseases Has associated exposure references Tetanus Toxin Has associated genes Has associated diseases

Top ↑ Descendants

Tetanus Toxin Has associated genes Has associated diseases
  azo-GnRH tetanus toxoid conjugate
  P30 tetanus toxin peptide
  tetanolysin
  tetanospasmin Has associated genes
  tetanus toxin (947-966)
  tetanus toxin fragment BIIb
  tetanus toxin fragment C
  zinc-endopeptidase, tetanus neurotoxin