Name | Thalidomide |
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CAS Type 1 Name | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- |
Equivalent Terms | Sedoval | Thalomid |
CAS Registry Number | 50-35-1 |
Definition | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. |
Structure | ![]() |
Top Interacting Genes |
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MeSH® ID | D013792 |
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