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Chemical Thalidomide

Name Thalidomide
CAS Type 1 Name 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
Equivalent Terms Sedoval | Thalomid
CAS Registry Number 50-35-1
Definition A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Structure Thalidomide
Top Interacting
Genes
MeSH® ID D013792
External Links
CCRIS
50-35-1
ChEBI
50-35-1
ChemIDplus®
50-35-1
DrugBank
DB01041
GENE-TOX
50-35-1
Household Products Database
50-35-1
HSDB®
50-35-1
PubChem
D013792
TOXLINE®
Query

Top ↑ Ancestors

1. Chemicals ← Organic Chemicals Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Carboxylic Acids Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Acids, Carbocyclic Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Phthalic Acids Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Phthalimides Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Thalidomide Has associated genes Has associated diseases Has associated phenotype references
2. Chemicals ← Heterocyclic Compounds Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Piperidines Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Piperidones Has associated genes Has associated diseases Has associated phenotype references ← Thalidomide Has associated genes Has associated diseases Has associated phenotype references
3. Chemicals ← Heterocyclic Compounds Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Heterocyclic Compounds, Fused-Ring Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Heterocyclic Compounds, 2-Ring Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Isoindoles Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Phthalimides Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Thalidomide Has associated genes Has associated diseases Has associated phenotype references

Top ↑ Descendants

Thalidomide Has associated genes Has associated diseases Has associated phenotype references
  1-O-methyl-2,3,4-tri-acetyl-6-tetrafluorophthalimido-6-deoxy-D-glucopyranose
  2-(2-(3-azido-4-iodophenylpropionamido)ethoxy)thalidomide
  2-(2,6-dioxopiperidin-3-yl)phthalimidine Has associated genes Has associated diseases
  3,6'-dithiothalidomide
  3-aminophthalimidoglutarimide
  3-fluorothalidomide
  3'-methylthalidomide
  4-fluorothalidomide
  5-hydroxythalidomide Has associated genes Has associated diseases Has associated phenotype references
  5'-hydroxythalidomide Has associated genes Has associated diseases
  5,N-dihydroxythalidomide
  apremilast
  ARV-825 Has associated genes Has associated diseases Has associated phenotype references
  CC 3052 Has associated genes Has associated diseases Has associated phenotype references
  CC-885
  CPS 11 Has associated genes Has associated diseases
  CPS 45
  CPS 49 Has associated genes Has associated diseases
  dBET1 compound
  DT-PACE protocol Has associated diseases
  DT PACE regimen
  EM 16
  EM 240
  hyperCDT protocol Has associated diseases
  K 2004-1c
  lenalidomide Has associated genes Has associated diseases Has associated phenotype references
  MDT protocol
  N-hydroxythalidomide
  N-phthalimidino glutaric acid
  N-phthalylisoglutamine
  phthalimidophthalimide
  pomalidomide Has associated genes Has associated diseases Has associated phenotype references
  SelCID-3
  supidimide Has associated diseases
  taglutimide Has associated diseases
  TCID protocol
  tetrafluorothalidomide