Skip navigation

Chemical Thiophenes

1–50 of 426 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1,2-dithiol-3-thione response to oxidative stress Hydrogen Peroxide | NFE2L2 [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide affects response to oxidative stress] 1: Mus musculus Embryonic Structures
35 genes: ALDH1A1 | APOE | APP | BTG1 | CAR3 | CAT | COX1 | CYCS | DDIT3 | EGFR | ETFDH | G6PDX | GCLC | GCLM | GPX2 | GSR | GSS | HMOX1 | JAK2 | KEAP1 | MAP2K1 | MBL2 | NDUFA6 | NQO1 | OXR1 | PEBP1 | PRDX1 | PRDX3 | PSMB5 | SELENOP | STK25 | TRAP1 | TXN2 | TXNIP | TXNRD1
1
2. 1,2-dithiol-3-thione protein oxidation Hydrogen Peroxide | NFE2L2 [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased protein oxidation] 1: Mus musculus Embryonic Structures   1
3. 1,2-dithiol-3-thione glutathione metabolic process Hydrogen Peroxide | NFE2L2 [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased glutathione metabolic process] 1: Mus musculus Embryonic Structures
16 genes: CTH | G6PDX | GCLC | GCLM | GLO1 | GSR | GSTA1 | GSTA2 | GSTA3 | GSTA5 | GSTK1 | GSTM1 | GSTM2 | GSTP1 | GSTT1 | GSTT2
1
4. 1,2-dithiol-3-thione cell proliferation irofulven 1,2-dithiol-3-thione promotes the reaction [irofulven results in decreased cell proliferation] 1: Homo sapiens HT29 Cells
40 genes: ADRA1B | CD74 | CDK5 | CITED2 | CREG1 | EGFR | ENPEP | ERBB2 | FGF2 | GAS6 | GLUL | GNB1 | HGF | IGF1 | IL18 | IL1A | IL2RA | INSIG1 | KLF10 | KRT16 | LIPA | LY86 | MAP2K1 | MIF | PDPN | PDZK1 | PRDX1 | PTEN | PTPN6 | PURA | RAP1B | SERPINF1 | SMAD4 | STAT3 | TOP2A | TXNRD1 | UBR5 | VEGFA | ZFP36L1 | ZFP37
1
5. 1,3-propane sultone GPI anchor biosynthetic process 1,3-propane sultone results in decreased GPI anchor biosynthetic process 1: Rattus norvegicus Reticulocytes 1 gene: PIGA 1
6. 2,2'-dithienyl diselenide negative regulation of sodium:potassium-exchanging ATPase activity 2,2'-dithienyl diselenide results in increased negative regulation of sodium:potassium-exchanging ATPase activity 1: Rattus norvegicus Brain | Subcellular Fractions   1
7. 2,2'-dithienyl diselenide glutathione metabolic process 2,2'-dithienyl diselenide results in increased glutathione metabolic process 1: Rattus norvegicus Brain | Subcellular Fractions   1
8. 2,2'-dithienyl diselenide glutathione metabolic process Glutathione [2,2'-dithienyl diselenide results in increased glutathione metabolic process] which results in increased oxidation of Glutathione 1: Rattus norvegicus Brain | Subcellular Fractions   1
9. 2,2'-dithienyl diselenide lipid oxidation 2,2'-dithienyl diselenide results in increased lipid oxidation 1: Rattus norvegicus Brain   1
10. 2,2'-dithienyl diselenide lipid oxidation Malondialdehyde [2,2'-dithienyl diselenide results in increased lipid oxidation] which results in increased abundance of Malondialdehyde 1: Rattus norvegicus Brain   1
11. 2,2'-dithienyl diselenide drinking behavior 2,2'-dithienyl diselenide results in decreased drinking behavior 1: Rattus norvegicus     1
12. 2,2'-dithienyl diselenide eating behavior 2,2'-dithienyl diselenide results in decreased eating behavior 1: Rattus norvegicus     1
13. 2,2'-dithienyl diselenide positive regulation of multicellular organism growth 2,2'-dithienyl diselenide results in decreased positive regulation of multicellular organism growth 1: Rattus norvegicus     1
14. 2,2'-dithienyl diselenide urea homeostasis 2,2'-dithienyl diselenide results in decreased urea homeostasis 1: Rattus norvegicus Blood   1
15. 2,2'-dithienyl diselenide urea homeostasis Urea [2,2'-dithienyl diselenide results in decreased urea homeostasis] which results in increased abundance of Urea 1: Rattus norvegicus Blood   1
16. 2,2'-dithienyl diselenide negative regulation of sodium:potassium-exchanging ATPase activity Dithiothreitol Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in increased negative regulation of sodium:potassium-exchanging ATPase activity] 1: Rattus norvegicus Brain | Subcellular Fractions   1
17. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide positive regulation of apoptotic process Cisplatin 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [Cisplatin results in increased positive regulation of apoptotic process] 1: Rattus norvegicus Kidney Tubules, Proximal | Epithelial Cells | Cell Line
4 genes: CASP3 | IL6 | RELA | TNF
1
18. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide regulation of NIK/NF-kappaB signaling IL1B 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [IL1B protein results in increased regulation of NIK/NF-kappaB signaling] 1: Homo sapiens Bronchi | Epithelial Cells | Cell Line 1 gene: RELA 1
19. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide positive regulation of protein import into nucleus resiquimod 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [resiquimod results in increased positive regulation of protein import into nucleus] 1: Homo sapiens Monocytes | Cells, Cultured   1
20. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide positive regulation of protein import into nucleus IRF5 | resiquimod 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [[resiquimod results in increased positive regulation of protein import into nucleus] which affects the localization of IRF5 protein] 1: Homo sapiens Monocytes | Cells, Cultured   1
21. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one protein poly-ADP-ribosylation Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased protein poly-ADP-ribosylation] 1: Mus musculus Lung 1 gene: PARP1 1
22. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one positive regulation of collagen biosynthetic process Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased positive regulation of collagen biosynthetic process] 1: Mus musculus Lung 1 gene: TGFB1 1
23. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one positive regulation of lung goblet cell differentiation Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased positive regulation of lung goblet cell differentiation] 1: Mus musculus Lung | Epithelium   1
24. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one DNA modification Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased DNA modification] 1: Mus musculus Lung | Epithelium   1
25. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one DNA modification 8-oxo-7-hydrodeoxyguanosine | Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [[Bleomycin results in increased DNA modification] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine] 1: Mus musculus Lung | Epithelium   1
26. 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene intestinal motility Morphine 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene inhibits the reaction [Morphine results in decreased intestinal motility] 1: Mus musculus Feces   1
27. 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene intestinal motility 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene results in decreased intestinal motility 1: Mus musculus Feces   1
28. 3-(4-azidobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thiophene regulation of ion transmembrane transporter activity CFTR [3-(4-azidobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thiophene results in decreased activity of CFTR protein] which results in decreased regulation of ion transmembrane transporter activity 1: Mus musculus Fibroblasts | Cell Line   1
29. 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide positive regulation of glucose metabolic process INS1 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide promotes the reaction [INS1 protein results in increased positive regulation of glucose metabolic process] 1: Rattus norvegicus Muscle Fibers, Skeletal | Cells, Cultured 1 gene: AKT2 1
30. 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide positive regulation of glucose import INS1 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide promotes the reaction [INS1 protein results in increased positive regulation of glucose import] 1: Rattus norvegicus Muscle Fibers, Skeletal | Cells, Cultured 1 gene: AKT2 1
31. 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide gluconeogenesis INS1 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide inhibits the reaction [INS1 protein affects gluconeogenesis] 1: Rattus norvegicus Hepatocytes | Cells, Cultured
2 genes: G6PC | PCK1
1
32. 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide positive regulation of cell death 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide results in increased positive regulation of cell death 1: Homo sapiens Mammary Glands, Human | Cell Line, Tumor   1
33. 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide positive regulation of cell death 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide results in increased positive regulation of cell death 1: Mus musculus Epithelial Cells | Cell Line, Tumor   1
34. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 1: Homo sapiens HEK293 Cells   1
35. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 3: Canis lupus familiaris | Mus musculus | Rattus norvegicus     1
36. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process Naloxone | OPRM1 Naloxone inhibits the reaction [[OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process] 1: Homo sapiens HEK293 Cells   1
37. A 769662 glucose import across plasma membrane A 769662 results in decreased glucose import across plasma membrane 1: Homo sapiens HCT116 Cells   1
38. A 769662 lactate biosynthetic process A 769662 results in decreased lactate biosynthetic process 1: Homo sapiens HCT116 Cells   1
39. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens HCT116 Cells 1 gene: TNF 1
40. A 769662 glucose import across plasma membrane A 769662 results in decreased glucose import across plasma membrane 1: Homo sapiens HT29 Cells   1
41. A 769662 lactate biosynthetic process A 769662 results in decreased lactate biosynthetic process 1: Homo sapiens HT29 Cells   1
42. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens HT29 Cells 1 gene: TNF 1
43. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens Caco-2 Cells 1 gene: TNF 1
44. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens Colon | Cell Line, Tumor 1 gene: TNF 1
45. A 769662 AMP-activated protein kinase activity A 769662 results in increased AMP-activated protein kinase activity 1: Mus musculus Heart   1
46. A 769662 positive regulation of protein serine/threonine kinase activity A 769662 results in increased positive regulation of protein serine/threonine kinase activity 1: Mus musculus Heart   1
47. A 769662 positive regulation of neutrophil differentiation Lipopolysaccharides A 769662 inhibits the reaction [Lipopolysaccharides results in increased positive regulation of neutrophil differentiation] 1: Mus musculus Blood   1
48. A 769662 AMP-activated protein kinase activity Lipopolysaccharides [A 769662 co-treated with Lipopolysaccharides] results in increased AMP-activated protein kinase activity 1: Mus musculus Heart   1
49. A 769662 positive regulation of protein serine/threonine kinase activity Lipopolysaccharides [A 769662 co-treated with Lipopolysaccharides] results in increased positive regulation of protein serine/threonine kinase activity 1: Mus musculus Heart   1
50. A 769662 positive regulation of neutrophil differentiation (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | Lipopolysaccharides (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [A 769662 inhibits the reaction [Lipopolysaccharides results in increased positive regulation of neutrophil differentiation]] 1: Mus musculus Blood   1
1–50 of 426 results.