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Chemical Thiophenes

1–50 of 404 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1,2-dithiol-3-thione protein oxidation Hydrogen Peroxide | NFE2L2 [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased protein oxidation] 1: Mus musculus Embryonic Structures   1
2. 1,2-dithiol-3-thione response to oxidative stress Hydrogen Peroxide | NFE2L2 [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide affects response to oxidative stress] 1: Mus musculus Embryonic Structures
35 genes: ALDH1A1 | APOE | APP | BTG1 | CAR3 | CAT | COX1 | CYCS | DDIT3 | EGFR | ETFDH | G6PDX | GCLC | GCLM | GPX2 | GSR | GSS | HMOX1 | JAK2 | KEAP1 | MAP2K1 | MBL2 | NDUFA6 | NQO1 | OXR1 | PEBP1 | PRDX1 | PRDX3 | PSMB5 | SELENOP | STK25 | TRAP1 | TXN2 | TXNIP | TXNRD1
1
3. 1,2-dithiol-3-thione glutathione metabolic process Hydrogen Peroxide | NFE2L2 [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased glutathione metabolic process] 1: Mus musculus Embryonic Structures
16 genes: CTH | G6PDX | GCLC | GCLM | GLO1 | GSR | GSTA1 | GSTA2 | GSTA3 | GSTA5 | GSTK1 | GSTM1 | GSTM2 | GSTP1 | GSTT1 | GSTT2
1
4. 1,2-dithiol-3-thione cell proliferation irofulven 1,2-dithiol-3-thione promotes the reaction [irofulven results in decreased cell proliferation] 1: Homo sapiens HT29 Cells
40 genes: ADRA1B | CD74 | CDK5 | CITED2 | CREG1 | EGFR | ENPEP | ERBB2 | FGF2 | GAS6 | GLUL | GNB1 | HGF | IGF1 | IL18 | IL1A | IL2RA | INSIG1 | KLF10 | KRT16 | LIPA | LY86 | MAP2K1 | MIF | PDPN | PDZK1 | PRDX1 | PTEN | PTPN6 | PURA | RAP1B | SERPINF1 | SMAD4 | STAT3 | TOP2A | TXNRD1 | UBR5 | VEGFA | ZFP36L1 | ZFP37
1
5. 1,3-propane sultone GPI anchor biosynthetic process 1,3-propane sultone results in decreased GPI anchor biosynthetic process 1: Rattus norvegicus Reticulocytes 1 gene: PIGA 1
6. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide positive regulation of protein import into nucleus resiquimod 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [resiquimod results in increased positive regulation of protein import into nucleus] 1: Homo sapiens Monocytes | Cells, Cultured   1
7. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide positive regulation of protein import into nucleus IRF5 | resiquimod 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [[resiquimod results in increased positive regulation of protein import into nucleus] which affects the localization of IRF5 protein] 1: Homo sapiens Monocytes | Cells, Cultured   1
8. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide positive regulation of apoptotic process Cisplatin 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [Cisplatin results in increased positive regulation of apoptotic process] 1: Rattus norvegicus Kidney Tubules, Proximal | Epithelial Cells | Cell Line
4 genes: CASP3 | IL6 | RELA | TNF
1
9. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide regulation of NIK/NF-kappaB signaling IL1B 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [IL1B protein results in increased regulation of NIK/NF-kappaB signaling] 1: Homo sapiens Bronchi | Epithelial Cells | Cell Line 1 gene: RELA 1
10. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one DNA modification Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased DNA modification] 1: Mus musculus Lung | Epithelium   1
11. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one positive regulation of lung goblet cell differentiation Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased positive regulation of lung goblet cell differentiation] 1: Mus musculus Lung | Epithelium   1
12. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one protein poly-ADP-ribosylation Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased protein poly-ADP-ribosylation] 1: Mus musculus Lung 1 gene: PARP1 1
13. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one positive regulation of collagen biosynthetic process Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased positive regulation of collagen biosynthetic process] 1: Mus musculus Lung 1 gene: TGFB1 1
14. 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one DNA modification 8-oxo-7-hydrodeoxyguanosine | Bleomycin 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [[Bleomycin results in increased DNA modification] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine] 1: Mus musculus Lung | Epithelium   1
15. 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene intestinal motility Morphine 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene inhibits the reaction [Morphine results in decreased intestinal motility] 1: Mus musculus Feces   1
16. 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene intestinal motility 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene results in decreased intestinal motility 1: Mus musculus Feces   1
17. 3-(4-azidobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thiophene regulation of ion transmembrane transporter activity CFTR [3-(4-azidobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thiophene results in decreased activity of CFTR protein] which results in decreased regulation of ion transmembrane transporter activity 1: Mus musculus Fibroblasts | Cell Line   1
18. 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide positive regulation of glucose import INS1 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide promotes the reaction [INS1 protein results in increased positive regulation of glucose import] 1: Rattus norvegicus Muscle Fibers, Skeletal | Cells, Cultured 1 gene: AKT2 1
19. 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide gluconeogenesis INS1 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide inhibits the reaction [INS1 protein affects gluconeogenesis] 1: Rattus norvegicus Hepatocytes | Cells, Cultured
2 genes: G6PC | PCK1
1
20. 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide positive regulation of glucose metabolic process INS1 3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide promotes the reaction [INS1 protein results in increased positive regulation of glucose metabolic process] 1: Rattus norvegicus Muscle Fibers, Skeletal | Cells, Cultured 1 gene: AKT2 1
21. 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide positive regulation of cell death 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide results in increased positive regulation of cell death 1: Homo sapiens Mammary Glands, Human | Cell Line, Tumor   1
22. 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide positive regulation of cell death 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide results in increased positive regulation of cell death 1: Mus musculus Epithelial Cells | Cell Line, Tumor   1
23. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 1: Homo sapiens HEK293 Cells   1
24. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process OPRM1 [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process 3: Canis lupus familiaris | Mus musculus | Rattus norvegicus     1
25. ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine cAMP biosynthetic process Naloxone | OPRM1 Naloxone inhibits the reaction [[OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased cAMP biosynthetic process] 1: Homo sapiens HEK293 Cells   1
26. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens HCT116 Cells 1 gene: TNF 1
27. A 769662 positive regulation of protein serine/threonine kinase activity Lipopolysaccharides [A 769662 co-treated with Lipopolysaccharides] results in increased positive regulation of protein serine/threonine kinase activity 1: Mus musculus Heart   1
28. A 769662 positive regulation of protein serine/threonine kinase activity (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [A 769662 results in increased positive regulation of protein serine/threonine kinase activity] 1: Mus musculus Heart   1
29. A 769662 positive regulation of neutrophil differentiation Lipopolysaccharides A 769662 inhibits the reaction [Lipopolysaccharides results in increased positive regulation of neutrophil differentiation] 1: Mus musculus Blood   1
30. A 769662 positive regulation of protein serine/threonine kinase activity (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | Lipopolysaccharides (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[A 769662 co-treated with Lipopolysaccharides] results in increased positive regulation of protein serine/threonine kinase activity] 1: Mus musculus Heart   1
31. A 769662 AMP-activated protein kinase activity Lipopolysaccharides [A 769662 co-treated with Lipopolysaccharides] results in increased AMP-activated protein kinase activity 1: Mus musculus Heart   1
32. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens Colon | Cell Line, Tumor 1 gene: TNF 1
33. A 769662 lactate biosynthetic process A 769662 results in decreased lactate biosynthetic process 1: Homo sapiens HT29 Cells   1
34. A 769662 positive regulation of neutrophil differentiation (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | Lipopolysaccharides (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [A 769662 inhibits the reaction [Lipopolysaccharides results in increased positive regulation of neutrophil differentiation]] 1: Mus musculus Blood   1
35. A 769662 AMP-activated protein kinase activity A 769662 results in increased AMP-activated protein kinase activity 1: Mus musculus Heart   1
36. A 769662 lactate biosynthetic process A 769662 results in decreased lactate biosynthetic process 1: Homo sapiens HCT116 Cells   1
37. A 769662 positive regulation of protein serine/threonine kinase activity A 769662 results in increased positive regulation of protein serine/threonine kinase activity 1: Mus musculus Heart   1
38. A 769662 AMP-activated protein kinase activity (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | Lipopolysaccharides (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[A 769662 co-treated with Lipopolysaccharides] results in increased AMP-activated protein kinase activity] 1: Mus musculus Heart   1
39. A 769662 AMP-activated protein kinase activity (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [A 769662 results in increased AMP-activated protein kinase activity] 1: Mus musculus Heart   1
40. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens HT29 Cells 1 gene: TNF 1
41. A 769662 glucose import across plasma membrane A 769662 results in decreased glucose import across plasma membrane 1: Homo sapiens HCT116 Cells   1
42. A 769662 glucose import across plasma membrane A 769662 results in decreased glucose import across plasma membrane 1: Homo sapiens HT29 Cells   1
43. A 769662 cell proliferation A 769662 results in decreased cell proliferation 1: Homo sapiens Caco-2 Cells 1 gene: TNF 1
44. alpha-terthienyl regulation of protein kinase C activity alpha-terthienyl analog affects regulation of protein kinase C activity     2
45. alpha-terthienyl reactive oxygen species biosynthetic process SOD [alpha-terthienyl results in increased reactive oxygen species biosynthetic process] which results in decreased activity of SOD protein 1: Lepidoptera Ovary | Cell Line   1
46. alpha-terthienyl positive regulation of apoptotic process alpha-terthienyl results in increased positive regulation of apoptotic process 1: Homo sapiens Kidney | HEK293 Cells 1 gene: BAX 1
47. alpha-terthienyl mitotic cell cycle arrest alpha-terthienyl results in increased mitotic cell cycle arrest 1: Lepidoptera Ovary | Cell Line   1
48. alpha-terthienyl reactive oxygen species biosynthetic process CAT [alpha-terthienyl results in increased reactive oxygen species biosynthetic process] which results in decreased activity of CAT protein 1: Lepidoptera Ovary | Cell Line   1
49. alpha-terthienyl cell proliferation alpha-terthienyl analog results in decreased cell proliferation 1: Homo sapiens Cell Line, Tumor
4 genes: ACHE | AR | BAX | PCNA
1
50. alpha-terthienyl peripheral nervous system axon regeneration alpha-terthienyl analog affects peripheral nervous system axon regeneration 1: Danio rerio Lateral Line System | Neurons   1
1–50 of 404 results.