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Chemical Tumor Necrosis Factor-alpha

Name Tumor Necrosis Factor-alpha
Equivalent Terms Cachectin | Cachectin Tumor Necrosis Factor | Cachectin-Tumor Necrosis Factor | TNFalpha | TNF-alpha | TNF Superfamily, Member 2 | Tumor Necrosis Factor | Tumor Necrosis Factor alpha | Tumor Necrosis Factor Ligand Superfamily Member 2
Definition Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D014409
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Top ↑ Ancestors

1. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Cytokines Has associated genes Has associated diseases Monokines Tumor Necrosis Factor-alpha
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Cytokines Has associated genes Has associated diseases Tumor Necrosis Factors Tumor Necrosis Factor-alpha

Top ↑ Descendants

Tumor Necrosis Factor-alpha
  58 kDa tumor necrosis factor-inducing protein, Mycobacterium tuberculosis
  F 4168
  F 4614
  His-TRAIL protein, recombinant
  LK-805
  LZ-TRAIL protein, recombinant
  mTNF-PADRE
  mutein 3
  mutein 5
  mutein 6
  mutein TNF 471
  PEG-modified tumor necrosis factor-alpha
  RM4-TNF protein, recombinant
  serum tumorlytic factor
  TNF protein, human
  TNF-SAM2
  TNF-selectokine
  tumor necrosis factor (1-12)
  tumor necrosis factor (1-26)
  tumor necrosis factor (41-62)
  tumor necrosis factor (78-96)
  tumor necrosis factor alpha (36-68)
  tumor necrosis factor alpha (70-80)
  tumor necrosis factor-alpha, CNGRC fusion protein, human
  tumor Necrosis Factor-alpha, CNGRC fusion protein, mouse
  tumor necrosis factor precursor
  XENP 1595