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Chemical Droxidopa

Name Droxidopa
CAS Type 1 Name L-Tyrosine, beta,3-dihydroxy-, threo-
Equivalent Terms 3,4 Dihydroxyphenylserine | 3,4-Dihydroxyphenylserine | 3,4 threo DOPS | 3,4-threo-DOPS | DL threo 3,4 Dihydroxyphenylserine | DL-threo-3,4-Dihydroxyphenylserine | Droxidopa, (DL-Tyr)-Isomer | erythro 3,4 Dihydroxyphenylserine | erythro-3,4-Dihydroxyphenylserine | threo DOPS | threo-DOPS
CAS Registry Number 23651-95-8
Definition A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Structure Droxidopa
Curation Status No gene interactions have been curated for this chemical yet.
MeSH® ID D015103
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1. ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Amines Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Biogenic Amines Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Biogenic Monoamines Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Catecholamines Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Norepinephrine Has associated genes Has associated diseases Has associated phenotype references Droxidopa Has associated diseases Has associated phenotype references
2. ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Amines Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Catecholamines Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Norepinephrine Has associated genes Has associated diseases Has associated phenotype references Droxidopa Has associated diseases Has associated phenotype references

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Droxidopa Has associated diseases Has associated phenotype references
  3-(3,4-dihydroxyphenyl)-N-methylserine