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Chemical Zidovudine

Name Zidovudine
CAS Type 1 Name Thymidine, 3'-azido-3'-deoxy-
Equivalent Terms 3' Azido 2',3' Dideoxythymidine | 3'-Azido-2',3'-Dideoxythymidine | 3' Azido 3' deoxythymidine | 3'-Azido-3'-deoxythymidine | Antiviral AZT | Azidothymidine | AZT Antiviral | AZT (Antiviral) | AZT, Antiviral | BWA509U | BW A509U | BWA 509U | BWA-509U | Retrovir
CAS Registry Number 30516-87-1
Definition A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
Structure Zidovudine
Top Interacting
Genes
MeSH® ID D015215
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Top ↑ Ancestors

1. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated exposure references Pyrimidines Has associated genes Has associated diseases Has associated exposure references Pyrimidine Nucleosides Has associated genes Has associated diseases Thymidine Has associated genes Has associated diseases Zidovudine Has associated genes Has associated diseases
2. ChemicalsNucleic Acids, Nucleotides, and Nucleosides Has associated genes Has associated diseases Has associated exposure references Nucleosides Has associated genes Has associated diseases Has associated exposure references Deoxyribonucleosides Has associated genes Has associated diseases Has associated exposure references Dideoxynucleosides Has associated genes Has associated diseases Zidovudine Has associated genes Has associated diseases
3. ChemicalsNucleic Acids, Nucleotides, and Nucleosides Has associated genes Has associated diseases Has associated exposure references Nucleosides Has associated genes Has associated diseases Has associated exposure references Deoxyribonucleosides Has associated genes Has associated diseases Has associated exposure references Thymidine Has associated genes Has associated diseases Zidovudine Has associated genes Has associated diseases
4. ChemicalsNucleic Acids, Nucleotides, and Nucleosides Has associated genes Has associated diseases Has associated exposure references Nucleosides Has associated genes Has associated diseases Has associated exposure references Pyrimidine Nucleosides Has associated genes Has associated diseases Thymidine Has associated genes Has associated diseases Zidovudine Has associated genes Has associated diseases

Top ↑ Descendants

Zidovudine Has associated genes Has associated diseases
  1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine
  1-((2-azido-1-(hydroxymethyl)ethoxy)methyl)thymine
  1-(2-azido-2-deoxyarabinofuranosyl)thymine
  1,2-dimyristoylphosphatidylazidothymidine
  1-(3-azido-2,3-dideoxy-2-fluoroarabinofuranosyl)thymine
  1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-arabinofuranosyl)uracil
  1-methyl-5-(3-azido-2,3-dideoxy-beta-pentofuranosyl)uracil
  2-amino-9-(3-azido-2,3-dideoxy-erythro-pentofuranosyl)-6-(1-pyrrolidinyl)-9H-purine
  2'-azido-2',3'-dideoxythymidine
  2-(mannopyranosidyl)ethyl 3'-azido-3'-deoxy-5'-thymidinyl phosphate
  3',5-diazido-2',3'-dideoxyuridine
  3'-azido-2',3'-dideoxy-5-(N-15-(6-(3,5-dimethylphenylthio)-5-ethyl-1-(5-oxopentyl)uracil)-4,15-diaza-3-oxopentadecanyl)uridine
  3'-azido-2',3'-dideoxy-5-(N-9-(6-(3,5-dimethylphenylthio)-5-ethyl-1-(5-oxopentyl)uracil)-4,9-diaza-3-oxononanyl)uridine
  3'-azido-2',3'-dideoxy-5'-O-((1,4-dihydro-1-methyl-3-pyridyl)carbonyl)uridine
  3'-azido-2',3'-dideoxy-N-(1-methoxycarbonyl-2-(3-indolyl)eth-1-yl)thymidine 5'-phosphoramidate
  3'-azido-2',3'-dideoxy-N-(1-methylaminocarbonyl-2-(3-indolyl)eth-1-yl)thymidine 5'-phosphoramidate
  3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate
  3'-azido-2',3'-dideoxyuridine
  3'-azido-2',3'-dideoxyuridine 5'-monophosphate
  3'-azido-2',3'-dideoxyuridine-5'-O-valinate
  3'-azido-2'-deoxythymidine-5'-methylamino-L-tryptophanylphosphoramidate
  3'-azido-3',5'-dideoxythymidine-5'-methylphosphonic acid diphosphate
  3'-azido-3'-deoxy-4-thiothymidine
  3'-azido-3'-deoxy-5'-(1-hexadecylthio-2-methoxypropyl)phosphothymidine
  3'-azido-3'-deoxy-5'-O-((11-hydroxy-3-oxo-17-androst-4-enyl)carbonyl)thymidine
  3'-azido-3'-deoxy-5'-O-((16-cyano-11-hydroxy-3-oxo-17-androsta-1,4-dienyl)carbonyl)thymidine
  3'-azido-3'-deoxy-5'-O-beta-glucopyranuronosylthymidine
  3'-azido-3'-deoxy-5'-O-isonicotinoylthymidine
  3'-azido-3'-deoxyarabinothymidine
  3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxybutyl)carbonate
  3'-azido-3'-deoxythymidine-5'-((2-cyanoethyl)(24-ethylcholesta-5,22-dien-3-yl))phosphate
  3'-azido-3'-deoxythymidine 5'-(3-(1-O-hexadecyl-2-O-methylglycerol)phosphate)
  3'-azido-3'-deoxythymidine-5'-(4-bromophenyl methoxyalaninyl phosphate)
  3'-azido-3'-deoxythymidine 5'-(beta,gamma-imido)triphosphate
  3'-azido-3'-deoxythymidine-5'-bis(3,3-diacetoxy-propyl)phosphate
  3'-azido-3'-deoxythymidine-5'-((cholest-5-en-3-yl)(2-cyanoethyl))phosphate
  3'-azido-3'-deoxythymidine 5'-choline phosphate
  3'-azido-3'-deoxythymidine 5'-diphosphate
  3'-azido-3'-deoxythymidine-5'-methoxyalaninyl phosphate
  3'-azido-3'-deoxythymidine 5'-(O-hexadecyl)phosphate
  3'-azido-3'-deoxythymidine 5'phosphate
  3'-azido-3'-deoxythymidine 5'-triphosphate
  3'-azido-3'-deoxythymidine monophosphate diglyceride
  3'-azido-3'-deoxythymidine triphosphate distearoylglycerol
  3'-azido-5'-isocyano-3',5'-dideoxythymidine
  3'-azidothymidine-5'-bis(4-nitrophenyl)phosphate
  3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate
  3'-azidothymidine 5'-(p-methoxyphenyl methoxyalaninyl phosphate)
  4'-azidothymidine
  4'-azidothymidine 5'-triphosphate
  4'-seleno-AZT
  5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine
  5-azidomethyl-2'-deoxyuridine
  5-bromo-6,5'-epoxy-5,6-dihydro-3'-azido-3'-deoxythymidine
  5-bromo-6-methoxy-5, 6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate
  5-Bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-methoxyphenyl)methoxyalaninyl phosphate
  5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(4-bromophenyl methoxyalaninyl phosphate)
  5-carboxyethyl-3'-azido-3'-deoxythymidine
  5'-cholesteryl-ethyl-phosphoryl zidovudine
  5'-isoleucyl 3'-azido-3'-deoxythymidine
  5'-O-(1-adamantyl)-3'-azido-3'-deoxythymidine
  5'-O-succinylzidovudine
  6-glucopyranosyl 3'-azido-3'-deoxy-5'-thymidinyl phosphate
  6-mannopyranosyl 3'-azido-3'-deoxy-5'-thymidinyl phosphate
  azidothymidine homodinucleotide
  AZTp4A
  bis(4-acetoxybenzyl)zidovudine diphosphate
  bispivaloylthioethyl zidovudine monophosphate
  cholesteryl-phosphonyl zidovudine
  CP 92
  cyclosaligenyl 3'-azido-2',3'-dideoxythymidine monophosphate
  fozivudine tidoxil
  hydroxy tBuSATE phenylphosphotriester AZT derivative
  KNI 1039
  lamivudine, zidovudine drug combination Has associated diseases
  N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate
  N(4)-hexadecyl-2'-deoxyribocytidylyl-(3',5')-3'-azido-2',3'-deoxythymidine
  N(4)-palmitoyl-2'-deoxyribocytidylyl-(3',5')-3'-azido-2',3'-deoxythymidine
  O,O'-bis(3'-azido-3'-deoxythymidin-5'-yl)-O''-(2-((phenyloxy)carbonyl)phenyl)phosphate
  (P(1)-thymidine-3'-azido-2',3'-dideoxyriboside-5')-P(2)-(9-2-(phosphonomethoxypropyl)adenine)
  phosphoceramide azidothymidine
  scriptene
  trans-(5S,6S)-5-bromo-6, 5'-epoxy-5,6-dihydro-3'-azido-3'-deoxythymidine
  Trizivir Has associated diseases
  tuftsin-AZT conjugate
  zidovudine 5'-monophosphate-mannose-albumin conjugate