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Chemical Thiorphan

Name Thiorphan
CAS Type 1 Name Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-
Equivalent Terms (3-Mercapto-2-benzylpropionyl)glycine | Thiorphan, (R)-Isomer | Thiorphan, (S)-Isomer | Tiorphan
CAS Registry Number 76721-89-6
Definition A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Structure Thiorphan
Top Interacting
Genes
MeSH® ID D015244
External Links
ChEBI
76721-89-6
ChemIDplus®
76721-89-6
DrugBank
DB01654
Household Products Database
76721-89-6
PubChem
D015244
TOXLINE®
Query

Top ↑ Ancestors

1. Chemicals ← Organic Chemicals Has associated genes Has associated diseases Has associated exposure references ← Sulfur Compounds Has associated genes Has associated diseases Has associated exposure references ← Amino Acids, Sulfur Has associated genes Has associated diseases Has associated exposure references ← Thiorphan Has associated genes Has associated diseases
2. Chemicals ← Amino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated exposure references ← Amino Acids Has associated genes Has associated diseases Has associated exposure references ← Glycine Has associated genes Has associated diseases Has associated exposure references ← N-substituted Glycines Has associated genes Has associated diseases ← Thiorphan Has associated genes Has associated diseases

Top ↑ Descendants

Thiorphan Has associated genes Has associated diseases
  azidothiorphan
  dexecadotril
  ES 52
  GB 52
  leucine thiorphan
  racecadotril Has associated genes Has associated diseases
  retrothiorphan
  S-acetylthiorphan