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Chemical Thiorphan

Name Thiorphan
CAS Type 1 Name Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-
Equivalent Terms (3-Mercapto-2-benzylpropionyl)glycine | Thiorphan, (R)-Isomer | Thiorphan, (S)-Isomer | Tiorphan
CAS Registry Number 76721-89-6
Definition A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Structure Thiorphan
Top Interacting
Genes
MeSH® ID D015244
External Links
ChEBI
76721-89-6
ChemIDplus®
76721-89-6
DrugBank
DB01654
Household Products Database
76721-89-6
PubChem
D015244
TOXLINE®
Query

Top ↑ Ancestors

1. Chemicals ← Organic Chemicals Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Sulfur Compounds Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Amino Acids, Sulfur Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Thiorphan Has associated genes Has associated diseases Has associated phenotype references
2. Chemicals ← Amino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Amino Acids Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← Glycine Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references ← N-substituted Glycines Has associated genes Has associated diseases Has associated phenotype references ← Thiorphan Has associated genes Has associated diseases Has associated phenotype references

Top ↑ Descendants

Thiorphan Has associated genes Has associated diseases Has associated phenotype references
  azidothiorphan
  dexecadotril
  ES 52
  GB 52
  leucine thiorphan
  racecadotril Has associated genes Has associated diseases Has associated phenotype references
  retrothiorphan
  S-acetylthiorphan