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Chemical Factor XIIa

Name Factor XIIa
Equivalent Terms Activated Factor XII | Activator, Prekallikrein | Blood Coagulation Factor XII, Activated | Coagulation Factor XIIa | Factor XIIa, Coagulation | Factor XII, Activated | Fragments, Hageman-Factor | Hageman Factor Fragments | Hageman-Factor Fragments | Prekallikrein Activator | XIIa, Coagulation Factor
Definition Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D015956
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ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Blood Coagulation Factors Has associated genes Has associated diseases Has associated exposure references Factor XII Factor XIIa

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None.