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Chemical Zalcitabine

Name Zalcitabine
CAS Type 1 Name Cytidine, 2',3'-dideoxy-
Equivalent Terms 2',3' Dideoxycytidine | 2',3'-Dideoxycytidine | ddC (Antiviral) | Dideoxycytidine | Hivid | HIVID Roche | Hoffman-La Roche Brand of Zalcitabine | NSC606170 | NSC 606170 | NSC-606170 | Roche Brand of Zalcitabine
CAS Registry Number 7481-89-2
Definition A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Structure Zalcitabine
Top Interacting
Genes
MeSH® ID D016047
External Links

Top ↑ Ancestors

1. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated exposure references Pyrimidines Has associated genes Has associated diseases Has associated exposure references Pyrimidine Nucleosides Has associated genes Has associated diseases Cytidine Has associated genes Has associated diseases Deoxycytidine Has associated genes Has associated diseases Zalcitabine Has associated genes Has associated diseases
2. ChemicalsNucleic Acids, Nucleotides, and Nucleosides Has associated genes Has associated diseases Has associated exposure references Nucleosides Has associated genes Has associated diseases Has associated exposure references Deoxyribonucleosides Has associated genes Has associated diseases Has associated exposure references Deoxycytidine Has associated genes Has associated diseases Zalcitabine Has associated genes Has associated diseases
3. ChemicalsNucleic Acids, Nucleotides, and Nucleosides Has associated genes Has associated diseases Has associated exposure references Nucleosides Has associated genes Has associated diseases Has associated exposure references Deoxyribonucleosides Has associated genes Has associated diseases Has associated exposure references Dideoxynucleosides Has associated genes Has associated diseases Zalcitabine Has associated genes Has associated diseases
4. ChemicalsNucleic Acids, Nucleotides, and Nucleosides Has associated genes Has associated diseases Has associated exposure references Nucleosides Has associated genes Has associated diseases Has associated exposure references Pyrimidine Nucleosides Has associated genes Has associated diseases Cytidine Has associated genes Has associated diseases Deoxycytidine Has associated genes Has associated diseases Zalcitabine Has associated genes Has associated diseases

Top ↑ Descendants

Zalcitabine Has associated genes Has associated diseases
  1-(2,3-dideoxy-2,3-didehydro-2-fluoro-4-thioribofuranosyl)cytosine
  1-(2,3-dideoxy-2,3-difluoroarabinofuranosyl)cytosine
  1-(2,3-dideoxy-2-fluoropentofuranosyl)-5-fluorocytosine
  1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine
  1-(2,3-dideoxy-hexopyranosyl)cytosine
  1-(2,5-dideoxy-beta-hexofuranosyl)cytosine
  1,2-dioleoyl-glycero-3-phospho-5'-(2',3')-dideoxycytidine
  2',3'-didehydro-2',3'-dideoxy-N4 -hydroxy-5-fluorocytidine
  2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine
  2',3'-dideoxy-2',3'-dehydro-5-fluorocytidine triphosphate
  2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine
  2',3'-dideoxy-2',3'-methanocytidine
  2',3'-dideoxy-5-fluorocytidine 5'-triphosphate
  2',3'-dideoxy-5-methylcytidine
  2',3'-dideoxy-beta-5-fluorocytidine
  2',3'-dideoxycytidine monophosphate diglyceride
  2',3'-dideoxycytidinene
  3'-amino-2',3'-dideoxycytidine Has associated genes
  3'-azido-2',3'-dideoxy-5-methylcytidine
  3'-azido-2',3'-dideoxycytidine
  3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine
  3'-S-(2-Cyanoethyl-N,N-diisopropylphosphorothioamidite)- N4-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine
  3'-thio-2',3'-dideoxycytidine
  6-amino-3-(5-ethynyl-5-(hydroxymethyl)oxolan-2-yl)-3-hydroxypyrimidin-2-one
  beta-D-4'-C-ethynyl-2',3'-dideoxycytidine
  dexelvucitabine Has associated diseases
  N(4)-benzoyl-2',3'-dideoxy-2',3'-didehydrocytidine
  N4-((diisopropylamino)methylene)-2',3'-dideoxycytidine
  N4-((diisopropylamino)methylene)-3'-fluoro-2',3'-dideoxycytidine
  Racivir Has associated diseases
View node Lamivudine Has associated genes Has associated diseases