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Chemical Lymphocyte Function-Associated Antigen-1

Name Lymphocyte Function-Associated Antigen-1
Equivalent Terms alphaLbeta2, Integrin | Antigen-1, Lymphocyte Function-Associated | Integrin alphaLbeta2 | Leukocyte Function Associated Antigen-1 | LFA-1 | Lymphocyte Function Associated Antigen 1
Definition An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D016169
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Top ↑ Ancestors

1. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Antigens Has associated genes Has associated diseases Has associated exposure references Antigens, Surface Has associated diseases Cell Adhesion Molecules Has associated diseases CD11 Antigens Lymphocyte Function-Associated Antigen-1
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Antigens Has associated genes Has associated diseases Has associated exposure references Antigens, Surface Has associated diseases Cell Adhesion Molecules Has associated diseases Receptors, Lymphocyte Homing Lymphocyte Function-Associated Antigen-1

Top ↑ Descendants

None.