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Chemical Transforming Growth Factor beta

Name Transforming Growth Factor beta
Equivalent Terms Bone Derived Transforming Growth Factor | Bone-Derived Transforming Growth Factor | Factor, Milk Growth | Growth Factor, Milk | Milk Growth Factor | Platelet Transforming Growth Factor | TGFbeta | TGF-beta
Definition A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D016212
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Top ↑ Ancestors

1. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Cytokines Has associated genes Has associated diseases Transforming Growth Factor beta
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases TGF-beta Superfamily Proteins Transforming Growth Factor beta

Top ↑ Descendants

Transforming Growth Factor beta
  ADMP2 protein, Xenopus
  As60A protein, Anopheles stephensi
  betaIG-H3 protein
  DAF-7 protein, C elegans
  Dbl-1 protein, C elegans
  dvr1 protein, zebrafish
  fugacin
  gbb protein, Drosophila
  gonadal soma-derived factor, zebrafish
  latency-associated propeptide, TGF-beta
  myoglianin protein, Drosophila
  recombinant human bone morphogenetic protein-2
  sara protein, Drosophila
  screw protein, Drosophila
View node Transforming Growth Factor beta1
View node Transforming Growth Factor beta2
View node Transforming Growth Factor beta3
  TGF-beta5 protein, Xenopus laevis
  transforming growth factor beta1.2
  transforming growth factor beta2.3
  transforming growth factor beta4
  UNC-129 protein, C elegans
  univin
  Vg1 protein, Xenopus
  Xnr3 protein, Xenopus
  XNR4 protein, Xenopus