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Chemical Endothelins

Name Endothelins
Equivalent Terms Endothelin | Endothelium-Derived Vasoconstrictor Factors | Vasoconstrictor Factors, Endothelium-Derived
Definition 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Top Interacting
Genes
MeSH® ID D016232
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Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Endothelins Has associated genes Has associated diseases

Top ↑ Descendants

Endothelins Has associated genes Has associated diseases
  big endothelin-1(16-38), valine(22)-
  big endothelin-1 (19-37), Phe(22)-
  big-endothelin (1-22)
  big-endothelin (16-32)
  BQ 3020
  Cys(11)-Cys(15)-endothelin-1 (11-21) Has associated genes Has associated diseases
View node Endothelin-1
View node Endothelin-2
View node Endothelin-3
  endothelin-1,2-6-keto-PGF1-alpha
  endothelin (16-21)
  endothelin (16-21) amide
  endothelin 1, Ala(1,15)-
  endothelin 1, Ala(1,3,11,15)-
  endothelin 1, Ala(3,11)-
  endothelin-1, Ala(9)-
  endothelin 1, Dpr(1)-Asp(15)-
  endothelin-1, Pro(12)-
  endothelin-1, Thr(18)-gamma-methyl-Leu(19)-
  endothelin7-21(Leu7,Aib11,Cys(Acm)15)
  endothelin, Nle(7)-
  IRL 1620 Has associated genes Has associated diseases
  IRL 1720
  N(epsilon)-9-azidobenzoyliodoendothelin-1
  preproendothelin 2
  preproendothelin-3
  proendothelin-1 (22-39)
  proendothelin-1 (31-38)
  proendothelin 2
  proendothelin 3