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Chemical Tacrolimus

Name Tacrolimus
CAS Type 1 Name 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-
Equivalent Terms Anhydrous Tacrolimus | Anhydrous, Tacrolimus | FK506 | FK 506 | FK-506 | FR900506 | FR 900506 | FR-900506 | Prograf | Prograft | Tacrolimus Anhydrous | Tacrolimus, Anhydrous
CAS Registry Number 109581-93-3
Definition A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Structure Tacrolimus
Top Interacting
Genes
MeSH® ID D016559
External Links

Top ↑ Ancestors

ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Lactones Has associated genes Has associated diseases Has associated exposure references Macrolides Has associated genes Has associated diseases Has associated exposure references Tacrolimus Has associated genes Has associated diseases

Top ↑ Descendants

Tacrolimus Has associated genes Has associated diseases
  13,15-O-bidesmethylascomycin
  13-desmethoxy-13-methyl-FK 520
  13-O-demethyl tacrolimus
  13-O-desmethylascomycin
  15,31-desmethyl FK-506
  15-desmethyl FK-506
  15-O-desmethylascomycin
  15-O-desmethyl-FK 520
  31-O-demethyl-FK506
  32-ascomycinyloxyacetic acid Has associated diseases
  32-O-(1-hydroxyethylindol-5-yl)ascomycin
  32-O-acetyltacrolimus
  9-deoxo-31-O-demethyl-FK506
  A 85917
  antascomicin A
  antascomicin B
  antascomicin C
  antascomicin D
  antascomicin E
  AP 1510
  AP 1889
  AP20187 Has associated genes Has associated diseases
  AP23510
  C24-deoxyascomycin
  CP 123369
  dexamethasone-FK506 heterodimer
  FK 1012
  FK1706
  FK 506-dextran conjugate
  GPI 1485
  immunomycin Has associated genes Has associated diseases
  JNJ460
  L 683519
  L 683590
  L 685818
  L 688617
  L 733725
  MLD 987
  pimecrolimus Has associated genes Has associated diseases
  SDZ 281-240