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Chemical Aflatoxin B1

Name Aflatoxin B1
CAS Type 1 Name Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-
Equivalent Terms Aflatoxin B | Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled | Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled | Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled | Aflatoxin B1, cis(+,-)-Isomer | Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer | HSDB3453 | HSDB 3453 | HSDB-3453 | NSC529592 | NSC 529592 | NSC-529592
CAS Registry Number 1162-65-8
Definition A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Structure Aflatoxin B1
Top Interacting
Genes
MeSH® ID D016604
External Links

Top ↑ Ancestors

1. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated exposure references Pyrans Has associated genes Has associated diseases Has associated exposure references Benzopyrans Has associated genes Has associated diseases Has associated exposure references Aflatoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references
2. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, Fused-Ring Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 2-Ring Has associated genes Has associated diseases Has associated exposure references Benzopyrans Has associated genes Has associated diseases Has associated exposure references Aflatoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references
3. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Mycotoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references

Top ↑ Descendants

Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references
  2,3-dihydro-2,3-dihydroxyaflatoxin B(1)
  2,3-dihydro-2,3-(N(5)-formyl-2',5',6'-triamino-4-oxo-N(5)-pyrimidyl)-3-hydroxyaflatoxin B(1)
  2,3-dihydro-2-(N(7)-guanyl)-3-hydroxyaflatoxin B1
  8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B1
  8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 Has associated genes Has associated diseases
  8,9-dihydroxy-8,9-dihydro-aflatoxin B1
  aflatoxin B1-2,3-oxide Has associated genes Has associated diseases
  aflatoxin B1-8,9-dichloride
  aflatoxin B1-8,9-dihydrodiol-Tris buffer complex
  aflatoxin B1-bovine serum albumin Has associated genes Has associated diseases
  aflatoxin B1-DNA adduct Has associated genes Has associated diseases
  aflatoxin B1-formamidopyrimidine
  aflatoxin B1-lysine adduct Has associated exposure references
  aflatoxin-B1-N7-guanine Has associated diseases
  aflatoxin B1-(O-carboxymethyl)oxime