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Chemical Aflatoxin B1

Name Aflatoxin B1
CAS Type 1 Name Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-
Equivalent Terms Aflatoxin B | Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled | Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled | Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled | Aflatoxin B1, cis(+,-)-Isomer | Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer | HSDB3453 | HSDB 3453 | HSDB-3453 | NSC529592 | NSC 529592 | NSC-529592
CAS Registry Number 1162-65-8
Definition A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Structure Aflatoxin B1
Top Interacting
Genes
MeSH® ID D016604
External Links
CCRIS
1162-65-8
ChEBI
1162-65-8
ChemIDplus®
1162-65-8
GENE-TOX
1162-65-8
Household Products Database
1162-65-8
HSDB®
1162-65-8
PubChem
D016604
TOXLINE®
Query

Top ↑ Ancestors

1. Chemicals ← Heterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references ← Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated exposure references ← Pyrans Has associated genes Has associated diseases Has associated exposure references ← Benzopyrans Has associated genes Has associated diseases Has associated exposure references ← Aflatoxins Has associated genes Has associated diseases Has associated exposure references ← Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references
2. Chemicals ← Heterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references ← Heterocyclic Compounds, 2-Ring Has associated genes Has associated diseases Has associated exposure references ← Benzopyrans Has associated genes Has associated diseases Has associated exposure references ← Aflatoxins Has associated genes Has associated diseases Has associated exposure references ← Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references
3. Chemicals ← Biological Factors Has associated genes Has associated diseases Has associated exposure references ← Toxins, Biological Has associated genes Has associated diseases Has associated exposure references ← Mycotoxins Has associated genes Has associated diseases Has associated exposure references ← Aflatoxins Has associated genes Has associated diseases Has associated exposure references ← Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references

Top ↑ Descendants

Aflatoxin B1 Has associated genes Has associated diseases Has associated exposure references
  2,3-dihydro-2,3-dihydroxyaflatoxin B(1)
  2,3-dihydro-2,3-(N(5)-formyl-2',5',6'-triamino-4-oxo-N(5)-pyrimidyl)-3-hydroxyaflatoxin B(1)
  2,3-dihydro-2-(N(7)-guanyl)-3-hydroxyaflatoxin B1
  8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B1
  8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 Has associated genes Has associated diseases
  8,9-dihydroxy-8,9-dihydro-aflatoxin B1
  aflatoxin B1-2,3-oxide Has associated genes Has associated diseases
  aflatoxin B1-8,9-dichloride
  aflatoxin B1-8,9-dihydrodiol-Tris buffer complex
  aflatoxin B1-bovine serum albumin Has associated genes Has associated diseases
  aflatoxin B1-DNA adduct Has associated genes Has associated diseases
  aflatoxin B1-formamidopyrimidine
  aflatoxin B1-lysine adduct Has associated exposure references
  aflatoxin-B1-N7-guanine Has associated diseases
  aflatoxin B1-(O-carboxymethyl)oxime