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Chemical Aflatoxin M1

Name Aflatoxin M1
CAS Type 1 Name Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-
Equivalent Terms 4 Hydroxyaflatoxin B1 | 4-Hydroxyaflatoxin B1 | Aflatoxin M | Aflatoxin M1, cis(+-)-Isomer
CAS Registry Number 6795-23-9
Definition A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Structure Aflatoxin M1
Top Interacting
Genes
MeSH® ID D016607
External Links

Top ↑ Ancestors

1. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 1-Ring Has associated genes Has associated diseases Has associated exposure references Pyrans Has associated genes Has associated diseases Has associated exposure references Benzopyrans Has associated genes Has associated diseases Has associated exposure references Aflatoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxin M1 Has associated genes Has associated diseases Has associated exposure references
2. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, Fused-Ring Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 2-Ring Has associated genes Has associated diseases Has associated exposure references Benzopyrans Has associated genes Has associated diseases Has associated exposure references Aflatoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxin M1 Has associated genes Has associated diseases Has associated exposure references
3. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Toxins, Biological Has associated genes Has associated diseases Has associated exposure references Mycotoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxins Has associated genes Has associated diseases Has associated exposure references Aflatoxin M1 Has associated genes Has associated diseases Has associated exposure references

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Aflatoxin M1 Has associated genes Has associated diseases Has associated exposure references
  aflatoxin M1-(O-carboxymethyl)oxime