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Chemical Lupus Coagulation Inhibitor

Name Lupus Coagulation Inhibitor
Equivalent Terms Anticoagulant, Lupus | Coagulation Inhibitor, Lupus | Inhibitor, Lupus Coagulation | Lupus Anticoagulant
Definition An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
Curation Status No gene interactions have been curated for this chemical yet.
MeSH® ID D016682
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ChemicalsBiological Factors Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Blood Coagulation Factor Inhibitors Has associated diseases Lupus Coagulation Inhibitor Has associated diseases

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