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Chemical Monocrotaline

Name Monocrotaline
CAS Type 1 Name 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
Equivalent Terms Monocrotaline, (all-xi)-Isomer | Monocrotaline Hydrochloride (13alpha,14alpha)-Isomer
CAS Registry Number 315-22-0
Definition A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Structure Monocrotaline
Top Interacting
Genes
MeSH® ID D016686
External Links

Top ↑ Ancestors

1. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Alkaloids Has associated genes Has associated diseases Has associated exposure references Pyrrolizidine Alkaloids Has associated genes Has associated diseases Monocrotaline Has associated genes Has associated diseases
2. ChemicalsHeterocyclic Compounds Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, Fused-Ring Has associated genes Has associated diseases Has associated exposure references Heterocyclic Compounds, 2-Ring Has associated genes Has associated diseases Has associated exposure references Pyrrolizidine Alkaloids Has associated genes Has associated diseases Monocrotaline Has associated genes Has associated diseases

Top ↑ Descendants

Monocrotaline Has associated genes Has associated diseases
  7-cysteinyldehydroretronecine
  dehydroretronecine
  monocrotaline pyrrole Has associated genes Has associated diseases
  trichodesmine